Circadian Rhythm Regulator REV-ERBα Attenuates Neuroapoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats

Zhou, Lu; Shen, Haitao; Li, Xiang; Li, Haiying; You, Wanchun; Wang, Zhong; Chen, Gang

doi:10.1007/s11064-023-03872-5

Cited by 1 publication

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References 27 publications

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“…Studies have confirmed that exogenous melatonin administration attenuated ischemic stroke injury, improved neurological deficits, and protected the integrity of the blood-brain barrier (BBB) [ 70 , 71 ]. REV-ERBα agonists (e.g., SR9009), acting as pharmacological regulators of the circadian rhythm, inhibited neuronal apoptosis during early brain injury after subarachnoid hemorrhage [ 72 ].…”

Section: Ischemic Strokementioning

confidence: 99%

The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective

2023

Aging dis

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Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological and pathophysiological processes in the body. Recently, a bidirectional relationship between circadian rhythms and several neurological diseases has been reported. Neurological diseases can lead to the disruption of circadian homeostasis, thereby increasing disease severity. Therefore, optimizing the current treatments through circadian-based approaches, including adjusted dosing, changing lifestyle, and targeted interventions, offer a promising opportunity for better clinical outcomes and precision medicine. In this review, we provide detailed implications of the circadian rhythm in neurological diseases through bench-to-bedside approaches. Furthermore, based on the unsatisfactory clinical outcomes, we critically discuss the potential of circadian-based interventions, which may encourage more studies in this discipline, with the hope of improving treatment efficacy in neurological diseases.

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Section: Ischemic Strokementioning

confidence: 99%

The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective

2023

Aging dis

View full text Add to dashboard Cite

show abstract

Circadian Rhythm Regulator REV-ERBα Attenuates Neuroapoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats

Cited by 1 publication

References 27 publications

The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective

The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective

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