Circadian rhythms in leukocyte trafficking

Druzd, David; Juan, Alba de; Scheiermann, Christoph

doi:10.1007/s00281-013-0414-4

Cited by 29 publications

(37 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…circadian clock | temperature compensation | mathematical models C ircadian rhythms are daily oscillations in gene expression and protein concentration that regulate sleep (1, 2), metabolism (3,4), and a host of other biological processes (5)(6)(7)(8). Circadian oscillations are known to be present in nearly all animals and plants, as well as some fungi and bacteria (9).…”

mentioning

confidence: 99%

Temperature compensation and temperature sensation in the circadian clock

Kidd

Young

Siggia

2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

All known circadian clocks have an endogenous period that is remarkably insensitive to temperature, a property known as temperature compensation, while at the same time being readily entrained by a diurnal temperature oscillation. Although temperature compensation and entrainment are defining features of circadian clocks, their mechanisms remain poorly understood. Most models presume that multiple steps in the circadian cycle are temperature-dependent, thus facilitating temperature entrainment, but then insist that the effect of changes around the cycle sums to zero to enforce temperature compensation. An alternative theory proposes that the circadian oscillator evolved from an adaptive temperature sensor: a gene circuit that responds only to temperature changes. This theory implies that temperature changes should linearly rescale the amplitudes of clock component oscillations but leave phase relationships and shapes unchanged. We show using timeless luciferase reporter measurements and Western blots against TIMELESS protein that this prediction is satisfied by the Drosophila circadian clock. We also review evidence for pathways that couple temperature to the circadian clock, and show previously unidentified evidence for coupling between the Drosophila clock and the heat-shock pathway.circadian clock | temperature compensation | mathematical models C ircadian rhythms are daily oscillations in gene expression and protein concentration that regulate sleep (1, 2), metabolism (3,4), and a host of other biological processes (5-8). Circadian oscillations are known to be present in nearly all animals and plants, as well as some fungi and bacteria (9). In all organisms in which circadian oscillations have been observed, circadian oscillations satisfy three defining properties (10). First, circadian oscillations are self-sustained and spontaneously maintain a period of about 24 h. Second, the circadian rhythm is sensitive to light and temperature and can be synchronized to external oscillations in the quantity of either. Third, the period of the circadian oscillation is "temperature-compensated"; that is, the endogenous period of the oscillation is relatively insensitive to temperature.The genetic basis of circadian clocks has been elucidated in considerable detail over the past two decades, particularly in the fruitfly Drosophila melanogaster, the mouse Mus musculus, and the bread mold Neurospora crassa (11). In Drosophila, a self-sustained circadian oscillation in neurons is generated when a pair of proteins, PERIOD (PER) and TIMELESS (TIM), dimerize and, after some delay, translocate into the nucleus, where the proteins repress their own transcription by inactivating a transcription factor dimer composed of the proteins CLOCK and CYCLE. Light sensitivity is mediated by the blue light photoreceptor CRYPTOCHROME (CRY), which upon activation binds TIMELESS and promotes TIMELESS degradation. A remarkably similar mechanism underlies circadian clocks in mouse and Neurospora. The circadian clock of cyanobacteria has also bee...

show abstract

mentioning

confidence: 99%

Temperature compensation and temperature sensation in the circadian clock

Kidd

Young

Siggia

2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…In contrast, the main drawbacks of the peripheral blood cell models are the considerable individual variability and sensitivity to factors that are independent of the course of the neuropsychiatric disorders (e.g. lifestyle, hormonal status, circadian rhythm, exposure to pathogens) (Druzd et al, 2014; Gladkevich et al, 2004). In addition, the number and function of circulating leukocytes are affected by the psychopharmacological treatment (Munzer et al, 2013; Tourjman et al, 2013).…”

Section: Patient Biomaterials Models Advantages and Limitationsmentioning

confidence: 99%

“…Notably, some CREB-mediated cellular functions are neuron-specific, but others – like the circadian rhythm regulation – are also present in peripheral cells (Druzd et al, 2014; Gaspar et al, 2014; McCarthy et al, 2013a). …”

Section: Understanding Pathophysiological Processes Using Hdfsmentioning

confidence: 99%

Human dermal fibroblasts in psychiatry research

et al. 2016

View full text Add to dashboard Cite

Summary In order to decipher the disease etiology, progression and treatment of multifactorial human brain diseases we utilize a host of different experimental models. Recently, patient-derived human dermal fibroblast (HDF) cultures have re-emerged as promising in vitro functional system for examining various cellular, molecular, metabolic and (patho)physiological states and traits of psychiatric disorders. HDF studies serve as a powerful complement to postmortem and animal studies, and often appear to be informative about the altered homeostasis in neural tissue. Studies of HDFs from patients with schizophrenia, depression, bipolar disorder, autism, attention deficit and hyperactivity disorder and other psychiatric disorders have significantly advanced our understanding of these devastating diseases. These reports unequivocally prove that signal transduction, redox homeostasis, circadian rhythms and gene*environment interactions are all amenable for assessment by the HDF model. Furthermore, the reported findings suggest that this underutilized patient biomaterial, combined with modern molecular biology techniques, may have both diagnostic and prognostic value, including prediction of response to therapeutic agents.

show abstract

“…Druzd et al [2] describe the impact of circadian cycles on hematopoietic stem cell niches and immune cell homing, another important physiological process that has been ignored for a long time by immunologists. The story begins with the finding that symptoms of inflammatory diseases manifest during particular time periods of the day and that shift workers have higher incidences.…”

mentioning

confidence: 99%

“…Circadian rhythms and their master genes have been well described but their influence on molecular mechanisms controlling leukocyte migration and homing was discovered just recently. In their review, Druzd and colleagues [2] provide an authoritative overview of the molecular clock machinery and its interface with the hematopoietic stem cell niche and immune cell system. The authors highlight that the expression level of vascular adhesion molecules and chemokines and the number of migrating immune cells vary according to diurnal/nocturnal cycles, which can influence clinical outcomes of therapies.…”

mentioning

confidence: 99%