Circadian rhythms in Neurospora crassa: Downstream effectors

Brody, Stuart; Oelhafen, Kim; Schneider, Kevin; Perrino, Sabrina; Goetz, Alexandra; Wang, Charlene; English, Carter

doi:10.1016/j.fgb.2009.09.006

Cited by 23 publications

(31 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is important to note that, in contrast to the banding of sod-1, frq 10 , these rhythms can only be detected on plates but not on race tubes (16,61). This may indicate that the menadione-induced banding has a high sensitivity to CO 2 .…”

Section: Ros-controlled Rhythms In Neurosporamentioning

confidence: 94%

“…Conidial density will be determined along the tube and density changes will be analyzed as a function of time allowing determination of period length, phase, or amplitude of the conidiation rhythm. By using a similar method, as described for the race tubes, rhythmic spore formation can also be analyzed when Neurospora cultures grow on plates (16).…”

Section: Circadian Rhythm In Neurosporamentioning

confidence: 99%

“…However, many of these rhythms are not temperaturecompensated and thus do not fulfill all criteria of a circadian rhythm. They are often dependent on supplementation of the growth medium with factors such as farnesol, geraniol, caffeine, or the ROS generator menadione (16,59,82), and/or are detected in specific single and double mutants (82,101,142,181).…”

Section: Frq-less Rhythms In Neurosporamentioning

confidence: 99%

“…In the meantime many details of ROS-regulated cellular functions have been described and novel ROS-related signaling pathways have been identified. Moreover, several data indicate an interrelationship between ROS signaling and the circadian rhythm in Neurospora, that is, ROS levels oscillate in a circadian manner, and vice versa, ROS homeostasis is involved in the control of the circadian rhythm (16,61,180,181). Very recently, circadian oxidation cycles of peroxiredoxin were shown in multiple organisms including Neurospora (47).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Interconnections of Reactive Oxygen Species Homeostasis and Circadian Rhythm inNeurospora crassa

Gyöngyösi

Káldi

2014

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Significance: Both circadian rhythm and the production of reactive oxygen species (ROS) are fundamental features of aerobic eukaryotic cells. The circadian clock enhances the fitness of organisms by enabling them to anticipate cycling changes in the surroundings. ROS generation in the cell is often altered in response to environmental changes, but oscillations in ROS levels may also reflect endogenous metabolic fluctuations governed by the circadian clock. On the other hand, an effective regulation and timing of antioxidant mechanisms may be crucial in the defense of cellular integrity. Thus, an interaction between the circadian timekeeping machinery and ROS homeostasis or signaling in both directions may be of advantage at all phylogenetic levels. Recent Advances: The Frequency-White Collar-1 and White Collar-2 oscillator (FWO) of the filamentous fungus Neurospora crassa is well characterized at the molecular level. Several members of the ROS homeostasis were found to be controlled by the circadian clock, and ROS levels display circadian rhythm in Neurospora. On the other hand, multiple data indicate that ROS affect the molecular oscillator. Critical Issues: Increasing evidence suggests the interplay between ROS homeostasis and oscillators that may be partially or fully independent of the FWO. In addition, ROS may be part of a complex cellular network synchronizing non-transcriptional oscillators with timekeeping machineries based on the classical transcription-translation feedback mechanism. Future Directions: Further investigations are needed to clarify how the different layers of the bidirectional interactions between ROS homeostasis and circadian regulation are interconnected. Antioxid. Redox Signal. 20,[3007][3008][3009][3010][3011][3012][3013][3014][3015][3016][3017][3018][3019][3020][3021][3022][3023]

show abstract

Section: Ros-controlled Rhythms In Neurosporamentioning

confidence: 94%

Section: Circadian Rhythm In Neurosporamentioning

confidence: 99%

Section: Frq-less Rhythms In Neurosporamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interconnections of Reactive Oxygen Species Homeostasis and Circadian Rhythm inNeurospora crassa

Gyöngyösi

Káldi

2014

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

show abstract

“…ROS greatly influences cyclic conidiation: menadione, a superoxideproducing compound, reduces this time period in WT and sod-1Δ strains, and the overexpression of sod-1 results in delayed conidiation (328,329). Menadione also reduces this time period in the ras-1 bd strain with increasing light intensity (330). H 2 O 2 (0.5 to 1 mM), besides light, activates the white collar complex; transcribes the cat-1 gene, the main catalase of conidiation (331); and generates a cat-1 mRNA cycle (332).…”

Section: Transitions From Vegetative Growth To Asexual Developmentmentioning

confidence: 99%

Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures

Riquelme

Aguirre

Bartnicki-García

et al. 2018

Microbiol Mol Biol Rev

289

246

View full text Add to dashboard Cite

SUMMARYFilamentous fungi constitute a large group of eukaryotic microorganisms that grow by forming simple tube-like hyphae that are capable of differentiating into more-complex morphological structures and distinct cell types. Hyphae form filamentous networks by extending at their tips while branching in subapical regions. Rapid tip elongation requires massive membrane insertion and extension of the rigid chitin-containing cell wall. This process is sustained by a continuous flow of secretory vesicles that depends on the coordinated action of the microtubule and actin cytoskeletons and the corresponding motors and associated proteins. Vesicles transport cell wall-synthesizing enzymes and accumulate in a special structure, the Spitzenkörper, before traveling further and fusing with the tip membrane. The place of vesicle fusion and growth direction are enabled and defined by the position of the Spitzenkörper, the so-called cell end markers, and other proteins involved in the exocytic process. Also important for tip extension is membrane recycling by endocytosis via early endosomes, which function as multipurpose transport vehicles for mRNA, septins, ribosomes, and peroxisomes. Cell integrity, hyphal branching, and morphogenesis are all processes that are largely dependent on vesicle and cytoskeleton dynamics. When hyphae differentiate structures for asexual or sexual reproduction or to mediate interspecies interactions, the hyphal basic cellular machinery may be reprogrammed through the synthesis of new proteins and/or the modification of protein activity. Although some transcriptional networks involved in such reprogramming of hyphae are well studied in several model filamentous fungi, clear connections between these networks and known determinants of hyphal morphogenesis are yet to be established.

show abstract

How Light Resets Circadian Clocks

2014

View full text Add to dashboard Cite

The daily revolutions of the earth around its axis are responsible for day and night and its annual orbit around the sun for the seasons with their fluctuations in day length. Most organisms have adapted to these diurnal and annual cycles. The strategies and mechanisms used are quite delicate and complicated.It came as a surprise that photosynthesis and many other processes are, however, additionally controlled by internal clocks. Thus, photosynthesis fluctuates not only during the daily light-dark cycle (=LD; see the List of Abbreviations and http://www.circadian.org/dictionary.html) but also when the plants are kept under LL and constant temperature (Hennessey and Field 1991). However, the period length (period for short) of this rhythmic event then deviates from exactly 24 h and is therefore called circadian (from Latin circa, about, and dies, day). If in the absence of LD and temperature cycles other 24 h time cues (also called zeitgeber, German for time giver) would control the rhythm, it should show an exact 24 h rhythm. This is not the case, demonstrating the endogenous nature of a clock that is locked to light signals (see Fig. 18.1). Spectrum of RhythmsEndogenous rhythms of organisms are not only tuned to the daily cycle of 24 h. The range of rhythms found in organisms covers ultradian (with periods of several hours to very short ones), circadian, and annual (with periods of about a year) rhythms. Other rhythms such as tidal, 14-day, and monthly ones cope with influences of the moon on the earth, mainly on the water movements of the oceans, and they are therefore found in organisms at the coasts and in the sea. Annual rhythms interact with the day-length changes during the year (see below). There are furthermore rhythms with periods covering several years. The following discussion of a "biological clock" is restricted to circadian rhythms. Even they are often not just composed of one clock type but form a "circadian system" consisting of two or more clocks with different prop- Function of Circadian ClocksThe term "clock" usually implies a time-measuring device or function. For instance, the day length (or night length) can be determined by an organism. Since day length is a function of the time of the year (long days in summer, short days in winter), it can be used to time certain events such as flowering or tuber formation of a plant or breeding of birds and mammals during the most appropriate season. These processes are denoted photoperiodism (see Chap. 19).However, a clock can also be used to set a certain temporal order. For instance, the circadian control of our sleepwake cycle ensures that we rise in the morning and fall asleep in the evening at a preferred time. Food intake and digestion are likewise controlled by this clock and gated to certain times of the day (Silver et al. 2011;Duguay and Cermakian 2009;Forsgren 1935). The circadian clock will time these events also under constant conditions. Furthermore, circadian clocks can serve as alarm clocks.

show abstract

Circadian rhythms in Neurospora crassa: Downstream effectors

Cited by 23 publications

References 43 publications

Interconnections of Reactive Oxygen Species Homeostasis and Circadian Rhythm inNeurospora crassa

Interconnections of Reactive Oxygen Species Homeostasis and Circadian Rhythm inNeurospora crassa

Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures

How Light Resets Circadian Clocks

Contact Info

Product

Resources

About