Circadian Rhythms in Stem Cell Biology and Function

Dierickx, Pieterjan; Pré, Bastiaan Du; Feyen, Dries; Geijsen, Niels; Veen, Toon van; Doevendans, Pieter A.; Laake, Linda W. van

doi:10.1007/978-3-319-25427-2_5

Cited by 10 publications

(15 citation statements)

References 128 publications

(130 reference statements)

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“…Adequate sleep seems to be crucial for biological regeneration through the activation of cell repair mechanisms mainly by the action of melatonin, which participates in the regulation of hormones, fatty acids metabolism, energy expenditures via insulin/IGF-1, and adult stem cells differentiation/proliferation [ 78 , 79 ]. Investigations indicate that disruption of the circadian rhythm is associated with impaired immunity, activation of pro-inflammatory cytokines [ 80 , 81 ], and cancer development [ 82 , 83 ].…”

Section: Discussionmentioning

confidence: 99%

Food Habits, Lifestyle Factors, and Risk of Prostate Cancer in Central Argentina: A Case Control Study Involving Self-Motivated Health Behavior Modifications after Diagnosis

Pacheco

Zapata

et al. 2016

Nutrients

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Cancer is the second most important non-communicable disease worldwide and disproportionately impacts low- to middle-income countries. Diet in combination with other lifestyle habits seems to modify the risk for some cancers but little is known about South Americans. Food habits of Argentinean men pre- and post-diagnosis of prostate cancer (n = 326) were assessed along with other lifestyle factors. We studied whether any of the behaviors and risk factors for prostate cancer were found in men with other cancers (n = 394), compared with control subjects (n = 629). Before diagnosis, both cases reported a greater mean consumption of meats and fats and lower intakes of fruits, green vegetables, cruciferous vegetables, legumes, nuts, seeds, and whole grains than the controls (all p < 0.001). After diagnosis, cases significantly reduced the intake of meats and fats, and reported other dietary modifications with increased consumption of fish, fruits (including red fruits in prostate cancer), cruciferous vegetables, legumes, nuts, and black tea (all p < 0.001). Additional lifestyle aspects significantly predominant in cases included a reduced quality of sleep, emotional stress, low physical activity, tobacco smoking, alcohol consumption, living in rural areas, and being exposed to environmental contaminants. Argentinian men were predisposed to modify their unhealthy dietary habits and other lifestyle factors after cancer diagnosis.

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Section: Discussionmentioning

confidence: 99%

Food Habits, Lifestyle Factors, and Risk of Prostate Cancer in Central Argentina: A Case Control Study Involving Self-Motivated Health Behavior Modifications after Diagnosis

Pacheco

Zapata

et al. 2016

Nutrients

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“…After accumulation and dimerization of PER and CRY in the cytoplasm, they translocate to the nucleus in which they inhibit BMAL1: CLOCK-mediated transcription [13] and therefore also their own transcription [14][15][16]. Disturbing this molecular negative feedback loop results in an affected period or amplitude of circadian rhythmicity [5,17].…”

Section: The Molecular Clock Comprises a Transcriptional/ Translationmentioning

confidence: 99%

“…In addition to transcriptional-based circadian rhythms, non-transcriptional oscillatory patterns in posttranscriptional/translational modulation [22], chromatin modifications [23], binding of RNA binding factors [24], redox [25], and metabolic [26] fluxes also occur. They mainly stabilize the precise regulation of the well-conserved clock pathway and contribute to its robustness (summarized in detail in [5]).…”

Section: The Molecular Clock Comprises a Transcriptional/ Translationmentioning

confidence: 99%

“…The importance of maintaining proper clock function is illustrated by the fact that its disturbance is implicated in multiple pathological conditions, such as impaired metabolism, cardiovascular diseases, sleep disorders, cancer, and even hampered regenerative capacities [5]. Therefore, the circadian clock is under intense investigation in differentiated cells, adult stem cells, and even embryonic stem cells.…”

Section: Introductionmentioning

confidence: 99%

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Circadian clocks: from stem cells to tissue homeostasis and regeneration

2017

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The circadian clock is an evolutionarily conserved timekeeper that adapts body physiology to diurnal cycles of around 24 h by influencing a wide variety of processes such as sleep‐to‐wake transitions, feeding and fasting patterns, body temperature, and hormone regulation. The molecular clock machinery comprises a pathway that is driven by rhythmic docking of the transcription factors BMAL1 and CLOCK on clock‐controlled output genes, which results in tissue‐specific oscillatory gene expression programs. Genetic as well as environmental perturbation of the circadian clock has been implicated in various diseases ranging from sleep to metabolic disorders and cancer development. Here, we review the origination of circadian rhythms in stem cells and their function in differentiated cells and organs. We describe how clocks influence stem cell maintenance and organ physiology, as well as how rhythmicity affects lineage commitment, tissue regeneration, and aging.

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“…REV-ERB | circadian rhythms | SR9009 | ligand | specificity T he cell-autonomous circadian clock regulates a plethora of physiological processes in the human body (1)(2)(3). The importance of proper clock maintenance is highlighted by linkages between circadian desynchrony and a variety of illnesses, including sleep and metabolic disorders, cardiovascular diseases, and cancer (1,2,(4)(5)(6)(7). This has fueled recent interest in the circadian clock as a therapeutic target (8)(9)(10)(11)(12).…”

mentioning

confidence: 99%