Circadian Rhythms in the Activity of Acetylcholinesterase of Human Erythrocytes Incubated <i>in vitro</i>

Mabood, S. Fazli; Newman, Peter F. J.; Nimmo, Ian A.

doi:10.1042/bst0060305

Cited by 11 publications

(6 citation statements)

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“…In 1976, Cornelius and Rensing showed rhythms in Mg 2þ -dependent ATPase activity in the membranes of RBCs kept in vitro (Cornelius and Rensing 1976). These results were later challenged by several studies failing to replicate the observed oscillations in enzymatic activities (Mabood et al 1978;Schrader andHolzapfel 1980). Nevertheless, in 1985, it was shown that human platelets incubated in vitro display oscillations in the levels of the low-molecular weight thiol, glutathione (GSH) (Radha et al 1985).…”

Section: Nothing New Under the Sun: The History Of The Research In Nomentioning

confidence: 99%

Cellular Timekeeping: It’s Redox o’Clock

Milev

Rhee

Reddy

2017

Cold Spring Harb Perspect Biol

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Mounting evidence in recent years supports the extensive interaction between the circadian and redox systems. The existence of such a relationship is not surprising because most organisms, be they diurnal or nocturnal, display daily oscillations in energy intake, locomotor activity, and exposure to exogenous and internally generated oxidants. The transcriptional clock controls the levels of many antioxidant proteins and redox-active cofactors, and, conversely, the cellular redox poise has been shown to feed back to the transcriptional oscillator via redox-sensitive transcription factors and enzymes. However, the circadian cycles in the -sulfinylation of the peroxiredoxin (PRDX) proteins constituted the first example of an autonomous circadian redox oscillation, which occurred independently of the transcriptional clock. Importantly, the high phylogenetic conservation of these rhythms suggests that they might predate the evolution of the transcriptional oscillator, and therefore could be a part of a primordial circadian redox/metabolic oscillator. This discovery forced the reappraisal of the dogmatic transcription-centered view of the clockwork and opened a new avenue of research. Indeed, the investigation into the links between the circadian and redox systems is still in its infancy, and many important questions remain to be addressed.

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Section: Nothing New Under the Sun: The History Of The Research In Nomentioning

confidence: 99%

Cellular Timekeeping: It’s Redox o’Clock

Milev

Rhee

Reddy

2017

Cold Spring Harb Perspect Biol

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“…Mammals have a natural supply of enucleated cells in RBCs, and researchers have plumbed this cell type for non-TTFL rhythms. In the 1970s, circadian rhythms in ATPase activity and periodic rhythms in enzymes—such as acetylcholinesterase, glyceraldehyde-3-phosphate dehydrogenase, and glucose-6-phosphate dehydrogenase—in RBCs were found ( Table 1), but it was unclear whether the rhythms were robust or persistent beyond 24 hours 10 .…”

Section: Blood: a Novel Source Of Post-translational Oscillator Rhythmsmentioning

confidence: 99%

A period without PER: understanding 24-hour rhythms without classic transcription and translation feedback loops

2019

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Since Ronald Konopka and Seymour Benzer’s discovery of the gene Period in the 1970s, the circadian rhythm field has diligently investigated regulatory mechanisms and intracellular transcriptional and translation feedback loops involving Period, and these investigations culminated in a 2017 Nobel Prize in Physiology or Medicine for Michael W. Young, Michael Rosbash, and Jeffrey C. Hall. Although research on 24-hour behavior rhythms started with Period, a series of discoveries in the past decade have shown us that post-transcriptional regulation and protein modification, such as phosphorylation and oxidation, are alternatives ways to building a ticking clock.

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“…However, it is also essential to understand the molecular basis for the timing of changes in gene expression through transcriptomics, based on the observation of enzymatic rhythms in the nuclei of red blood cells [26]. More recently, Johnston [27] analyzed the transcriptome of mice for 24 hours and detected the presence of circadian rhythms in adipocytes.…”

Section: Chronomicsmentioning

confidence: 99%

Application of Bioinformatics in Chronobiology Research

Lopes

Resende

Honório-França

et al. 2013

The Scientific World Journal

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Bioinformatics and other well-established sciences, such as molecular biology, genetics, and biochemistry, provide a scientific approach for the analysis of data generated through “omics” projects that may be used in studies of chronobiology. The results of studies that apply these techniques demonstrate how they significantly aided the understanding of chronobiology. However, bioinformatics tools alone cannot eliminate the need for an understanding of the field of research or the data to be considered, nor can such tools replace analysts and researchers. It is often necessary to conduct an evaluation of the results of a data mining effort to determine the degree of reliability. To this end, familiarity with the field of investigation is necessary. It is evident that the knowledge that has been accumulated through chronobiology and the use of tools derived from bioinformatics has contributed to the recognition and understanding of the patterns and biological rhythms found in living organisms. The current work aims to develop new and important applications in the near future through chronobiology research.

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Circadian Rhythms in the Activity of Acetylcholinesterase of Human Erythrocytes Incubated in vitro

Cited by 11 publications

References 0 publications

Cellular Timekeeping: It’s Redox o’Clock

Cellular Timekeeping: It’s Redox o’Clock

A period without PER: understanding 24-hour rhythms without classic transcription and translation feedback loops

Application of Bioinformatics in Chronobiology Research

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