Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolism

Munyoki, Sarah; Goff, Julie P.; Mullett, Steven J.; Burns, Jennifer K; Jenkins, Aaron; DePoy, Lauren M.; Wendell, Stacy G.; McClung, Colleen A.; Morrison, Kathleen E.; Jašarević, Eldin

doi:10.1101/2022.09.15.508006

Cited by 2 publications

(1 citation statement)

References 132 publications

(142 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These differences may be explained by underlying sex differences in circadian rhythm biology or the effects of circadian rhythm disruption. Indeed, there are numerous sex differences in circadian rhythms, including the function of the immune, metabolic, and endocrine systems (Munyoki et al, 2022;Walton et al, 2022). Moreover, there are sex differences in the metabolic consequences of circadian rhythm disruption, including the effects of ALAN (Masís-Vargas et al, 2019;Rumanova et al, 2020), simulated shift work (Qian et al, 2019), and jet lag (Feliciano et al, 2019), demonstrating precedence for the observed sex differences in this study.…”

Section: Discussionsupporting

confidence: 61%

Artificial light at night alters progression of cold neuropathy in a sex-dependent manner in a mouse model of type II diabetes mellitus

Bumgarner,

White,

Brown

et al. 2024

Front. Photon.

View full text Add to dashboard Cite

Artificial light at night (ALAN) is a pervasive circadian rhythm disruptor. Exposure to ALAN is associated with detrimental effects on physiology and behavior, including disrupted metabolism, immune function, endocrine function, and pain behavior. Given the detrimental effects of ALAN and other circadian rhythm disruptors on pain, we sought to understand how ALAN may alter the progression and severity of diabetic neuropathy. To do this, we used a previously reported high-fat diet and streptozotocin injection protocol to induce a type II diabetic phenotype in ∼8 week old female and male mice and then exposed the mice to either control or ALAN lighting conditions in 14:10 h light-dark cycles for 4 weeks. Male mice housed in control conditions exhibited reduced responsiveness to cold pain; in contrast, ALAN blunted this effect in male mice. ALAN exposure also elevated blood glucose and altered body mass loss in male mice. These effects were not present in female mice. The results of this study highlight the need to consider and study ALAN exposure and sex as a biological variable as risk factors in the treatment and mitigation of pain.

show abstract

Section: Discussionsupporting

confidence: 61%

Artificial light at night alters progression of cold neuropathy in a sex-dependent manner in a mouse model of type II diabetes mellitus

Bumgarner,

White,

Brown

et al. 2024

Front. Photon.

View full text Add to dashboard Cite

show abstract

Small Intestinal Microbiota Oscillations, Host Effects and Regulation—A Zoom into Three Key Effector Molecules

Ratiner

Fachler-Sharp

Elinav

2023

Biology

View full text Add to dashboard Cite

The gut microbiota features a unique diurnal rhythmicity which contributes to modulation of host physiology and homeostasis. The composition and activity of the microbiota and its secreted molecules influence the intestinal milieu and neighboring organs, such as the liver. Multiple immune-related molecules have been linked to the diurnal microbiota-host interaction, including Reg3γ, IgA, and MHCII, which are secreted or expressed on the gut surface and directly interact with intestinal bacteria. These molecules are also strongly influenced by dietary patterns, such as high-fat diet and time-restricted feeding, which are already known to modulate microbial rhythms and peripheral clocks. Herein, we use Reg3γ, IgA, and MHCII as test cases to highlight the divergent effects mediated by the diurnal activity of the gut microbiota and their downstream host effects. We further highlight current challenges and conflicts, remaining questions, and perspectives toward a holistic understanding of the microbiome’s impacts on circadian human behavior.

show abstract

Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolism

Cited by 2 publications

References 132 publications

Artificial light at night alters progression of cold neuropathy in a sex-dependent manner in a mouse model of type II diabetes mellitus

Artificial light at night alters progression of cold neuropathy in a sex-dependent manner in a mouse model of type II diabetes mellitus

Small Intestinal Microbiota Oscillations, Host Effects and Regulation—A Zoom into Three Key Effector Molecules

Contact Info

Product

Resources

About