Circadian Rhythms in Urinary Functions: Possible Roles of Circadian Clocks?

Noh, Jong-Yun; Han, Donghoon; Yoon, Ji-Ae; Kim, Mi-Hee; Kim, Sang Hoon; Ko, Il‐Gyu; Kim, Khae Hawn; Cho, Sehyung

doi:10.5213/inj.2011.15.2.64

Cited by 50 publications

(67 citation statements)

References 105 publications

(86 reference statements)

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“…Increased nocturnal diuresis might reflect an abnormal circadian rhythm of diuresis 7 . 9 Nocturnal polyuria is considered one of the major characteristics of monosymptomatic 10 nocturnal enuresis (MNE) 1,2,3 . The initial findings of decreased vasopressin (AVP) levels 11 associated with increased urine production with low osmolality overnight were recently 12 confirmed 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Circadian Rhythm of Glomerular Filtration and Solute Handling Related to Nocturnal Enuresis

et al. 2016

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We will provide journalists and editors with full-text copies of the articles in question prior to the embargo date so that stories can be adequately researched and written. The standard embargo time is 12:01 AM ET on that date. Questions regarding embargo should be directed to jumedia@elsevier.com. Abstract PURPOSEAlthough nocturnal polyuria in monosymptomatic enuresis (MNE) can largely be explained by the decreased nocturnal vasopressin secretion hypothesis, other circadian rhythms in the kidney also seem to play a role.Recently we documented an absent day/night rhythm in a subgroup of desmopressin (dDAVP) -refractory patients. The aim of this study was to explore the importance of abnormal circadian rhythm of glomerular filtration (GFR) and tubular (sodium, potassium) parameters in patients with MNE. MATERIALS AND METHODSThis retrospective study of a tertiary enuresis population collected data subsequent to a standardized screening (ICCS questionnaire, diary), 14 days diary for nocturnal enuresis and diuresis, and 24h concentration profile. The study population consisted of 139 children with nocturnal enuresis (NE) at least 5 years of age. The group of NMNE was used as control population for the children with MNE. RESULTSThere was a maintained circadian rhythm of GFR, sodium, osmotic excretion and diuresis-rate in both children with MNE and NMNE and there was no difference between the two groups. Secondary analysis revealed that in patients with nocturnal polyuria (both with MNE and NMNE), circadian rhythm of GFR, sodium, osmotic excretion and diuresis-rate was lost in contrast with patients without nocturnal polyuria (p<0.001). CONCLUSIONSCircadian rhythm of the kidney is not different between NMNE and MNE. However the subgroup of enuresis with nocturnal polyuria has a diminished circadian rhythm of nocturnal diuresis, sodiumexcretion and GFR in contrast with children without nocturnal polyuria. This observation cannot be explained by the vasopressin theory alone.

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Section: Introductionmentioning

confidence: 99%

Circadian Rhythm of Glomerular Filtration and Solute Handling Related to Nocturnal Enuresis

et al. 2016

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“…However, the 24-h periodicity of U-OSM can be altered in patients with HF and renal dysfunction, and is also influenced by multiple factors, including the amount and timing of fluid ingestion and medications. 10 Therefore, patients with preserved urinary concentrating ability, but impaired urinary circadian rhythm, may have a negative C1 result when tested only in the early morning. Optimal timing of U-OSM measurements for predicting the efficacy of TLV warrants further investigation in a larger population to reduce false-negative results.…”

Section: Article P 397mentioning

confidence: 99%

Urine Osmolality-Guided Tolvaptan Therapy in Decompensated Heart Failure

Dohi

Watanabe

2013

Circ J

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“…Knowing that daily urine production rhythms result from the integrative workings of several hormones (e.g. arginine vasopressin, aldosterone, plasma renin and natriuretic peptide), which are also regulated by the circadian timing system (Kamperis et al, 2004;Noh et al, 2011), it is possible that the regulatory pathways of each of these hormones respond differently to varying qualities of lighting and that this caused the dissociation between locomotor activity and urine production, quantitatively.…”

Section: Urine Production Ratementioning

confidence: 99%

“…Several processes that are tied to urine production clearly exhibit daily or circadian variations and are essential to the well-being of organisms (Kamperis et al, 2004;Noh et al, 2011). For example, the circadian timing of a bladder gap junction protein (connexin43), which regulates changes in bladder capacity, is fundamental for preventing micturition during sleep and thus improves sleep quality (Negoro et al, 2012).…”

Section: Urine Production Ratementioning

confidence: 99%

Effects of photophase illuminance on locomotor activity, urine production and urinary 6-sulfatoxymelatonin in nocturnal and diurnal South African rodents

Merwe

Oosthuizen

Ganswindt

et al. 2017

Journal of Experimental Biology

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Effects of photophase illuminance (1, 10, 100 and 330 lx of white incandescent lighting) on daily rhythms of locomotor activity, urine production and 6-sulfatoxymelatonin (6-SMT; 10 versus 330 lx) were studied in nocturnal Namaqua rock mice (Micaelamys namaquensis) and diurnal four-striped field mice (Rhabdomys pumilio). Micaelamys namaquensis was consistently nocturnal (∼90-94% nocturnal activity), whereas considerable individual variation marked activity profiles in R. pumilio, but with activity mostly pronounced around twilight (∼55-66% diurnal activity). The amplitude of daily activity was distinctly affected by light intensity and this effect was greater in M. namaquensis than in R. pumilio. Only M. namaquensis displayed a distinctive daily rhythm of urine production, which correlated with its activity rhythm. Mean daily urine production appeared to be attenuated under dim photophase conditions, particularly in R. pumilio. The results suggest that the circadian regulation of locomotor activity and urine production possesses separate sensitivity thresholds to photophase illuminance. Micaelamys namaquensis expressed a significant daily 6-SMT rhythm that peaked during the late night, but the rhythm was attenuated by the brighter photophase cycle (330 lx). Rhabdomys pumilio appeared to express an ultradian 6-SMT rhythm under both lighting regimes with comparable mean daily 6-SMT values, but with different temporal patterns. It is widely known that a natural dark phase which is undisturbed by artificial light is essential for optimal circadian function. Here, we show that light intensity during the photophase also plays a key role in maintaining circadian rhythms in rodents, irrespective of their temporal activity rhythm.

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Circadian Rhythms in Urinary Functions: Possible Roles of Circadian Clocks?

Cited by 50 publications

References 105 publications

Circadian Rhythm of Glomerular Filtration and Solute Handling Related to Nocturnal Enuresis

Circadian Rhythm of Glomerular Filtration and Solute Handling Related to Nocturnal Enuresis

Urine Osmolality-Guided Tolvaptan Therapy in Decompensated Heart Failure

Effects of photophase illuminance on locomotor activity, urine production and urinary 6-sulfatoxymelatonin in nocturnal and diurnal South African rodents

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