Circadian rhythms influence hematopoietic stem cells

Méndez-Ferrer, Simón; Chow, Andrew; Mérad, Miriam; Frenette, Paul S.

doi:10.1097/moh.0b013e32832bd0f5

Cited by 126 publications

(96 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Negative effects of dominant-negative Rho1 on the resident hemocyte pattern suggest a role for active cytoskeletal processes. These findings show intriguing parallels with vertebrates, in which hematopoietic stem and progenitor cells cycle between defined microenvironments and the peripheral blood (Adams and Scadden, 2006;Kaplan et al, 2007;Mendez-Ferrer et al, 2009;Ehninger and Trumpp, 2011).…”

Section: Research Articlementioning

confidence: 84%

The peripheral nervous system supports blood cell homing and survival in theDrosophilalarva

et al. 2011

View full text Add to dashboard Cite

SUMMARYInteractions of hematopoietic cells with their microenvironment control blood cell colonization, homing and hematopoiesis. Here, we introduce larval hematopoiesis as the first Drosophila model for hematopoietic colonization and the role of the peripheral nervous system (PNS) as a microenvironment in hematopoiesis. The Drosophila larval hematopoietic system is founded by differentiated hemocytes of the embryo, which colonize segmentally repeated epidermal-muscular pockets and proliferate in these locations. Importantly, we show that these resident hemocytes tightly colocalize with peripheral neurons and we demonstrate that larval hemocytes depend on the PNS as an attractive and trophic microenvironment. atonal (ato) mutant or genetically ablated larvae, which are deficient for subsets of peripheral neurons, show a progressive apoptotic decline in hemocytes and an incomplete resident hemocyte pattern, whereas supernumerary peripheral neurons induced by ectopic expression of the proneural gene scute (sc) misdirect hemocytes to these ectopic locations. This PNS-hematopoietic connection in Drosophila parallels the emerging role of the PNS in hematopoiesis and immune functions in vertebrates, and provides the basis for the systematic genetic dissection of the PNS-hematopoietic axis in the future.

show abstract

Section: Research Articlementioning

confidence: 84%

The peripheral nervous system supports blood cell homing and survival in theDrosophilalarva

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The circadian clock mechanism is regulated by a highly conserved set of genes encoding regulatory proteins. In mammals there is increasing evidence that stem cell activities are modulated by circadian regulatory proteins, and circadian oscillations in proliferative activity and recruitment of hematopoietic progenitor cells have been demonstrated [1,2]. Circadian rhythmic variation of the number of blood cells may have implication in immune defense, and accordingly Lee and Edery [3] have shown circadian regulation of the innate immune response of Drosophila melanogaster.…”

Section: Introductionmentioning

confidence: 99%

An ancient cytokine, astakine, mediates circadian regulation of invertebrate hematopoiesis

Watthanasurorot

Söderhäll

Jiravanichpaisal

et al. 2010

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Invertebrate circulating hemocytes are key players in the innate immune defense and their continuous renewal from hematopoietic tissues is tightly regulated in crustaceans by astakine, a new family of cytokines sharing a prokineticin (PROK) domain. In vertebrates, brain PROKs function as transmitters of circadian rhythms and we present evidence that hemocyte release from hematopoietic tissues in crayfish is under circadian regulation, a direct result of rhythmic expression of astakine. We demonstrate that the observed variation in astakine expression has an impact on innate immunity assessed as susceptibility to a pathogenic Pseudomonas species. These findings enlighten the importance of comparing immune responses at fixed times not to neglect circadian regulation of innate immunity. Moreover, our results entail an evolutionary conserved function for prokineticins as mediators of circadian rhythm, and for the first time show a role for this domain in circadian regulation of hematopoiesis that may have implications also in vertebrates.

show abstract

“…Oscillations in proliferative activity and recruitment of hematopoietic progenitor cells have been demonstrated in mammals. 41,42 Although vertebrate PROKs have been assigned a role as an suprachiasmatic nucleus output molecule, no role in regulating rhythmic oscillations in hematopoiesis has been proposed, and the expression pattern of Ast1 suggests an evolutionarily conserved function for PROK domain proteins in mediating circadian rhythms. Therefore, it should be of interest to see whether any PROK has such a role in vertebrate hematopoiesis.…”

Section: Crustacean Hematopoiesis Is Rhythmically Controlledmentioning

confidence: 99%