Circadian rhythms of blood pressure in hypertensive patients with cerebral microbleeds

Liang, Wen-Cong; Yuan, Shu-lan; Ni, Zhuo-Xin; Li, Wei; Liu, Yong‐Lin; Qu, Jian‐Feng

doi:10.1002/brb3.2530

Cited by 8 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SBP is the strongest predictor of stroke, with a 44% increase in stroke events for every 10‐mmHg increase in SBP 34 . CMBs had significantly higher mean SBP in comparison with those without CMBs 35 . There was no difference between 1 and 10 CMBs and more than 10 CMBs in morning systolic BPV in this study.…”

Section: Discussionmentioning

confidence: 46%

See 1 more Smart Citation

Relationship between morning blood pressure variability and cerebral microbleed burden in patients with hypertension

Zhang,

Ma,

Liu

et al. 2024

J of Clinical Hypertension

View full text Add to dashboard Cite

Cerebral microbleeds (CMBs) can be understood as a type of target organ damage caused by hypertension. We aimed to explore the association of the CMB burden with morning blood pressure (BP) variability in patients with hypertension. We divided patients with hypertension into two groups: a group with 1–10 CMBs and a group with more than 10 CMBs. The duration, grade, medication, and control of hypertension were recorded in all patients. Morning home BP measurements were performed every 3 days for a month. A total of 791 patients were recruited. Full factor model analysis showed that higher morning home diastolic BP variability (standard deviation [SD], OR = 1.080, 95% CI: 1.024–1.140, P = .005; coefficient of variation [CV], OR = 1.076, 95% CI: 1.028–1.128, P = .002) was associated with more than 10 CMBs. Morning home systolic and diastolic blood pressure variability (SD, CV, average real variability) in more than 10 non‐lobar CMBs group was significantly higher than that in 1–10 non‐lobar CMBs group (P < .05).The multivariate analysis showed higher morning home diastolic blood pressure variability (SD, OR = 1.124, 95% CI: 1.031–1.224, P = .008; CV, OR = 1.099, 95% CI: 1.019–1.186, P = .015; average real variability, OR = 1.055, 95% CI: 0.995–1.120, P = .075) was associated with more than 10 non‐lobar CMBs. There was no significant relationship between morning home systolic blood pressure variability and more than 10 non‐lobar CMBs (P > .05). Higher morning home diastolic blood pressure variability was associated with more than 10 CMBs and more than 10 non‐lobar CMBs.

show abstract

Section: Discussionmentioning

confidence: 46%

“…34 CMBs had significantly higher mean SBP in comparison with those without CMBs. 35 There was no difference between 1 and 10 CMBs and more than 10…”

Section: Discussionmentioning

confidence: 88%

Relationship between morning blood pressure variability and cerebral microbleed burden in patients with hypertension

Zhang,

Ma,

Liu

et al. 2024

J of Clinical Hypertension

View full text Add to dashboard Cite

show abstract

“…This suggested that the more pronounced CMB progression in DD carriers was not due to the influence of the D allele on HTN incidence. However, even in patients with HTN, the progression of CMBs may differ depending on the actual blood pressure control status and blood pressure variability ( 21 , 22 ). One of the limitations of our study was that we did not have detailed information on the level of blood pressure control and blood pressure variability.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion gene polymorphism and the progression of cerebral microbleeds

Yoon,

Kim,

Suh

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

Background and purposeThe angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism has been studied as a genetic candidate for cerebral small vessel disease (CSVD). However, no previous study has evaluated the relationship between the ACE I/D polymorphism and cerebral microbleed (CMB), an important CSVD marker. We evaluated the association between ACE I/D polymorphisms and 2-year changes in CMBs.MethodsThe CHALLENGE (Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes) database was analyzed. Of 256 subjects, 186 participants who underwent a 2-year follow-up brain scan and ACE genotyping were included. Our analysis was conducted by dividing the ACE genotype into two groups (DD vs. ID/II) under the assumption of the recessive effects of the D allele. A linear mixed-effect model was used to compare the 2-year changes in the number of CMBs between the DD and combined ID/II genotypes.ResultsAmong 186 patients included in this study, 24 (12.9%) had the DD genotype, 91 (48.9%) had the ID genotype, and 71 (38.2%) had the II genotype. Baseline clinical characteristics and cerebral small vessel disease markers were not different between the two groups (DD vs. ID/II) except for the prevalence of hypertension (DD 66.7% vs. ID/II 84.6%; p = 0.04). A multivariate linear mixed-effects model showed that the DD carriers had a greater increase in total CMB counts than the ID/II carriers after adjusting for the baseline number of CMBs, age, sex, and hypertension (estimated mean of difference [standard error (SE)] = 1.33 [0.61]; p = 0.03). When we performed an analysis of cases divided into deep and lobar CMBs, only lobar CMBs were significantly different between the two groups (estimated mean of difference [SE] = 0.94 [0.42]; p = 0.02).ConclusionThe progression of CMBs over 2 years was greater in the ACE DD carriers compared with the combined II/ID carriers. The results of our study indicate a possible association between the ACE I/D polymorphism and CMB. A study with a larger sample size is needed to confirm this association.

show abstract

“…100 Higher nighttime SBP or attenuated nocturnal dipping has also been associated with the presence of cerebral microbleeds (a feature of small vessel disease) in humans with hypertension. 102 Overall, the presence of hypertension at night may be more harmful than hypertension during daylight hours. 52,58,79,88…”

Section: Clinical Relevance Of Nighttime Bpmentioning

confidence: 99%

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

View full text Add to dashboard Cite

Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined. Here, we review the impact of daily rhythms and circadian systems in regulating blood pressure and the onset, progression, and consequences of hypertension. There is an emphasis on the impact of circadian biology in relation to vascular disease and end-organ effects that, individually or in combination, contribute to complex phenotypes such as cognitive decline and the loss of cardiac and brain health. Despite effective treatment options for some individuals, control of blood pressure remains inadequate in a substantial portion of the hypertensive population. Greater insight into circadian biology may form a foundation for novel and more widely effective molecular therapies or interventions to help in the prevention, treatment, and management of hypertension and its related pathophysiology.

show abstract

Circadian rhythms of blood pressure in hypertensive patients with cerebral microbleeds

Cited by 8 publications

References 30 publications

Relationship between morning blood pressure variability and cerebral microbleed burden in patients with hypertension

Relationship between morning blood pressure variability and cerebral microbleed burden in patients with hypertension

Angiotensin-converting enzyme insertion/deletion gene polymorphism and the progression of cerebral microbleeds

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Contact Info

Product

Resources

About