Circadian rhythms of folate and vitamin B12 concentration in relation to convulsive thresholds of mice

Hutchins, David A.; Ball, Peter

doi:10.1016/0197-0186(83)90071-2

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Our study also shows the key role of the circadian clock in the metabolism of vitamin B3, nicotinic acid (NA) constituting another source of NAD + . Interestingly, circulating levels of several vitamins, like vitamins A, B9, B12, D, E, and K, showed a diurnal rhythm in mammals (Hutchins and Ball, 1983; Piccione et al, 2004), but the role of the circadian clock in these rhythms has not yet been established. One exception is vitamin B6, for which a clear role of the clock has been demonstrated through the regulation of pyridoxal kinase ( Pdxk ) by the circadian clock-regulated proline acidic amino acid-rich basic leucine zipper (PARbZip) transcription factors (Gachon et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

et al. 2017

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SummaryLysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is therefore highly relevant in the context of circadian biology, but its characterization on the proteome-wide scale and its circadian clock dependence are still poorly described. Here, we provide a comprehensive and rhythmic acetylome map of the mouse liver. Rhythmic acetylated proteins showed subcellular localization-specific phases that correlated with the related metabolites in the regulated pathways. Mitochondrial proteins were over-represented among the rhythmically acetylated proteins and were highly correlated with SIRT3-dependent deacetylation. SIRT3 activity being nicotinamide adenine dinucleotide (NAD)+ level-dependent, we show that NAD+ is orchestrated by both feeding rhythms and the circadian clock through the NAD+ salvage pathway but also via the nicotinamide riboside pathway. Hence, the diurnal acetylome relies on a functional circadian clock and affects important diurnal metabolic pathways in the mouse liver.

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Section: Discussionmentioning

confidence: 99%

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

et al. 2017

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“…Appropriate cobalamin intake was controlled as each dog was fed their maintenance diet or a standardized diet that contained the recommended 35 μg of cobalamin/kg of dry matter 27 . Finally, in humans, cobalamin and transcobalamin concentrations can vary by 10% over a 24‐hour period and were not associated with mealtimes, circadian rhythm, age, or meal composition 28‐31 …”

Section: Discussionmentioning

confidence: 99%

“…27 Finally, in humans, cobalamin and transcobalamin concentrations can vary by 10% over a 24-hour period and were not associated with mealtimes, circadian rhythm, age, or meal composition. [28][29][30][31] The current TAMU Gastrointestinal Laboratory recommendations for cobalamin supplementation do not necessitate the need to make exact distinctions between hypocobalaminemia and low normal "gray zone" serum cobalamin concentrations. However, in the 14/51 of dogs that had a serum cobalamin status change at a postprandial time point compared with fasted values, 12/14 changed in terms of clinical interpretation (ie, necessity of cobalamin supplementation).…”

Section: Canine Pancreatic Lipase Immunoreactivitymentioning

confidence: 99%

The effect of feeding on serum concentrations of cobalamin, folate, trypsin‐like immunoreactivity, and pancreatic lipase immunoreactivity in dogs with signs of chronic gastrointestinal disease

Melco,

Pritchard,

Hetzel

et al. 2024

Veterinary Internal Medicne

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BackgroundIt is unknown if serum concentrations of cobalamin, folate, canine pancreatic lipase immunoreactivity (cPLI), and canine trypsin‐like immunoreactivity (cTLI) obtained postprandially are equivalent to measurements obtained after withholding food in dogs with suspected gastrointestinal disease.Hypothesis/ObjectivesMeasurements of serum concentrations of cobalamin, folate, cPLI, and cTLI postprandially will be equivalent to measurements after 12 hours of withholding food in dogs with signs of chronic gastrointestinal disease. Changes observed will not alter clinical interpretation.Animals51 client‐owned dogs with signs of gastrointestinal disease.MethodsProspective single arm clinical trial. Serum concentrations of cobalamin, folate, cPLI and cTLI 2, 4, and 8 hours postprandially were compared by equivalence testing to values after withholding food for 12 hours (baseline).ResultsMean serum cobalamin concentrations 2 hours (498.1 ± 213.1 ng/L; P = 0.024) and 4 hours (501.9 ± 207.4 ng/L; P = 0.008) postprandial were equivalent to baseline (517.3 ± 211.5 ng/L). Mean serum cTLI 2 hours (31.3 ± 14 μg/L; P < 0.001) and 4 hours (29.6 ± 13.1 μg/L; P = 0.027) postprandial were equivalent to baseline (31.1 ± 15 μg/L). Mean serum folate concentration 2 hours postprandial (15 ± 7.7 μg/L) was equivalent to baseline (13.7 ± 8.3 μg/L; P < 0.001). Equivalence could not be assessed for cPLI due to results below the lower limit of quantification. Feeding altered the clinical interpretation in 27% (cobalamin), 35% (folate), 20% (cTLI), and 12% (cPLI) of dogs.Conclusions and Clinical ImportanceThe clinical interpretation for a substantial number of samples changed after feeding, therefore withholding food before sample collection is prudent.

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Diurnal variation of folate concentrations in mouse embryo and plasma: The protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent

Wegner

Nau

1991

Reproductive Toxicology

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Circadian rhythms of folate and vitamin B12 concentration in relation to convulsive thresholds of mice

Cited by 4 publications

References 31 publications

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

The effect of feeding on serum concentrations of cobalamin, folate, trypsin‐like immunoreactivity, and pancreatic lipase immunoreactivity in dogs with signs of chronic gastrointestinal disease

Diurnal variation of folate concentrations in mouse embryo and plasma: The protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent

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