Circadian rhythms of food and water intake and urine excretion in diabetic rats

Plaza, A.; G-Granda, Teresa; Cachero, Martínez

doi:10.1016/0031-9384(93)90074-p

Cited by 10 publications

(1 citation statement)

References 21 publications

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“…Light/dark rhythms of water intake and urine output have been studied in rats and the findings show the highest values of these parameters are during the dark phase [Velasco Plaza et al, 1993]. Also, administration of melatonin to hamsters results in significant increases in water consumption and urine production [Richardson et al, 1992].…”

Section: Discussionmentioning

confidence: 99%

Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin‐induced nephrotoxicity in rats

Hara¹,

Yoshida²,

Nishijima³

et al. 2001

Journal of Pineal Research

106

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In an attempt to define the role of the pineal secretory melatonin and an analogue, 6-hydroxymelatonin (6-OHM), in limiting oxidative stress, the present study investigated the cisplatin (CP)-induced alteration in the renal antioxidant system and nephroprotection with the two indolamines. Melatonin (5 mg/kg), 6-OHM (5 mg/kg), or an equal volume of saline were administered intraperitoneally (i.p.) to male Sprague Dawley rats 30 min prior to an i.p. injection of CP (7 mg/kg). After CP treatment, the animals each received indolamine or saline every day and were sacrificed 3 or 5 days later and plasma as well as kidney were collected. Both plasma creatinine and blood urea nitrogen increased significantly following CP administration alone; these values decreased significantly with melatonin co-treatment of CP-treated rats. In the kidney, CP decreased the levels of GSH (reduced glutathione)/GSSG (oxidized glutathione) ratio, an index directly related to oxidative stress. When animals were treated with melatonin, the reduction in the GSH/GSSG ratio was prevented. Treatment of CP-enhanced lipid peroxidation in the kidney was again prevented in animals treated with melatonin. The activity of the antioxidant enzyme, glutathione peroxidase (GSH-Px), decreased as a result of CP administration, which was restored to control levels with melatonin co-treatment. Upon histological analysis, damage to the proximal tubular cells was seen in the kidneys of CP-treated rats; these changes were prevented by melatonin treatment. 6-OHM has been shown to have some antioxidative capacity, however, the protective effects of 6-OHM against CP-induced nephrotoxicity were less than those of melatonin. The residual platinum concentration in the kidney of melatonin co-treated rats was significantly lower than that of rats treated with CP alone. It is concluded that administration of CP imposes a severe oxidative stress to renal tissue and melatonin confers protection against the oxidative damage associated with CP. This mechanism may be reasonably attributed to its radical scavenging activity, to its GSH-Px activating property, and/or to its regulatory activity for renal function.

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Section: Discussionmentioning

confidence: 99%