Circadian rhythms of melatonin and peripheral clock gene expression in idiopathic REM sleep behavior disorder

Weissova, Kamila; Skrabalova, Jitka; Skálová, Kateřina; Červená, Kateřina; Bendová, Zdeňka; Miletínová, Eva; Kopřivová, Jana; Šonka, Karel; Dudysová, Daniela; Bartoš, Aleš; Bušková, Jitka

doi:10.1016/j.sleep.2018.07.019

Cited by 46 publications

(37 citation statements)

References 39 publications

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“…Patients should be in a dark room under low light intensity <50 lux [39]. Red dim light which does not interfere with MLT production is recommended [40].…”

Section: Materials Collectionmentioning

confidence: 99%

Melatonin-Measurement Methods and the Factors Modifying the Results. A Systematic Review of the Literature

Rzepka-Migut

Paprocka

2020

IJERPH

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Melatonin plays an important role in regulating the sleep–wake cycle and adaptation to environmental changes. Concentration measurements in bioliquids such as serum/plasma, saliva and urine are widely used to assess peripheral rhythm. The aim of the study was to compare methods and conditions of determinations carried out with the identification of factors potentially affecting the measurements obtained. We have identified a group of modifiable and unmodifiable factors that facilitate data interpretation. Knowledge of modifiers allows you to carefully plan the test protocol and then compare the results. There is no one universal sampling standard, because the choice of method and biofluid depends on the purpose of the study and the research group.

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“…Patients should be in a dark room under low light intensity <50 lux [39]. Red dim light which does not interfere with MLT production is recommended [40].…”

Section: Materials Collectionmentioning

confidence: 99%

Melatonin-Measurement Methods and the Factors Modifying the Results. A Systematic Review of the Literature

Rzepka-Migut

Paprocka

2020

IJERPH

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“…Studies of RBD genetics tend to center upon single nucleotide polymorphisms (SNPs) and genetic mutations known to be associated with the α-synucleinopathies. Genetic changes in RBD populations include underrepresentation of a PD-protective MAPT (Microtubule Associated Protein Tau) SNP ( 55 ), glucocerebrosidase missense variant overrepresentation ( 56 ), altered clock gene expression ( 57 ), and SNCA (Synuclein Alpha) gene variants ( 58 ). In each instance, however, the mutations are present in only a small minority of the RBD population thus limiting the conclusions that can be drawn regarding genetic determinants of RBD.…”

Section: Epidemiologymentioning

confidence: 99%

“…Melatonin has been shown to improve sleep quality and duration in both healthy and diseased individuals ( 97 , 98 ), and as sleep disorders are often multi-factorial, prescribing melatonin or melatonin-related compounds is often done to try to non-specifically stabilize any underlying circadian desynchronizations. In the case of RBD, where changes in REM circadian rhythmicity have been shown ( 57 , 99 ), blanket-prescription of melatonin may be beneficial for patients. However, as no blinded case-controlled trials have confirmed the stabilization of REM circadian rhythmicity by melatonin in RBD, the clinical- and cost-effectiveness of blanket prescription policy for healthcare systems should be taken into consideration by the clinician ( 100 ).…”

Section: Pharmacologicalmentioning

confidence: 99%

A Neurologist's Guide to REM Sleep Behavior Disorder

et al. 2020

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REM Sleep Behavior Disorder (RBD) is a chronic sleep condition characterized by dream enactment and loss of REM atonia. Individuals often present to clinic with complaints of injury to themselves or their bed-partner due to violent movements during sleep. RBD patients have a high risk of developing one of the neurodegenerative α-synucleinopathy diseases: over 70% will develop parkinsonism or dementia within 12 years of their diagnosis. RBD patients also exhibit accelerated disease progression and a more severe phenotype than α-synucleinopathy sufferers without RBD. The disease's low prevalence and the relatively limited awareness of the condition amongst medical professionals makes the diagnosis and treatment of RBD challenging. Uncertainty in patient management is further exacerbated by a lack of clinical guidelines for RBD patient care. There are no binary prognostic markers for RBD disease course and there are no clinical guidelines for neurodegeneration scaling or tracking in these patients. Both clinicians and patients are therefore forced to deal with uncertain outcomes. In this review, we summarize RBD pathology and differential diagnoses, diagnostic, and treatment guidelines as well as prognostic recommendations with a look to current research in the scientific field. We aim to raise awareness and develop a framework for best practice for RBD patient management.

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“…Melatonin ( N -acetyl-5-methoxy tryptamine) related to both nervous stimulation and endocrine secretion, is mainly produced by the pineal gland, and is also beneficial to the regulation of circadian rhythms [7]. Melatonin is essential to various biological activities, including anti-aging [8], anti-oxidation [9], anti-inflammation [10], anti-apoptosis [11] and anti-pyroptosis [12].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Inhibits Apoptosis and Oxidative Stress of Mouse Leydig Cells via a SIRT1-Dependent Mechanism

Zhao

Liu

et al. 2019

Molecules

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The purpose of the present study is to examine the effects of melatonin on apoptosis and oxidative stress in mouse Leydig cells and to elucidate the mechanisms responsible for these effects. Our results indicated that 10 ng/mL of melatonin significantly promoted cell viability, the ratio of EdU-positive (5-Ethynyl-2′-deoxyuridine) cells, and increased the mRNA expression of proliferating cell nuclear antigen (PCNA), cyclin D1(CCND1), and cell division control protein 42 (CDC42) (p < 0.05). We also observed that melatonin inhibited apoptosis of mouse Leydig cells, accompanied with increased B-cell lymphoma-2 (BCL-2) and decreased BCL2 associated X (BAX) mRNA and protein expression. Moreover, addition of melatonin significantly decreased the reactive oxygen species (ROS) production and malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels, while it increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels (p < 0.05). In addition, we also found that melatonin increased the expression of SIRT1 (Silent information regulator 1) (p < 0.05). To explore the role of SIRT1 signaling in melatonin-induced cells, mouse Leydig cells were pretreated with EX527, an inhibitor of SIRT1. The protective effects of melatonin on mouse Leydig cells were reversed by EX527, as shown by decreased cell proliferation and increased cell apoptosis and oxidative stress. In summary, our results demonstrated that melatonin inhibited apoptosis and oxidative stress of mouse Leydig cells through a SIRT1-dependent mechanism.

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Circadian rhythms of melatonin and peripheral clock gene expression in idiopathic REM sleep behavior disorder

Cited by 46 publications

References 39 publications

Melatonin-Measurement Methods and the Factors Modifying the Results. A Systematic Review of the Literature

Melatonin-Measurement Methods and the Factors Modifying the Results. A Systematic Review of the Literature

A Neurologist's Guide to REM Sleep Behavior Disorder

Melatonin Inhibits Apoptosis and Oxidative Stress of Mouse Leydig Cells via a SIRT1-Dependent Mechanism

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