Circadian Rhythms of Serum Estradiol and Corticosterone and Related Organ Weight Changes in the Prepubertal Female Rat

Nelson, Marita L.; Cullin, Anne-Marie; Hoffmann, Joan C.

doi:10.1095/biolreprod18.1.125

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…The presence of diurnal variations in serum estradiol levels in 2 1 -and 24-day-old rats has been reported by Nel son et al [20], Dohler and Wuttke [6] suggested the possibili ty of diurnal changes in serum estradiol levels in the female rat at 25-30 days of age, finding a tendency of estradiol lev els to increase at 11.00-15.00 h. The present results confirm those earlier findings. Furthermore, it was indicated from the present experiment that the estradiol rhythm, which peaked at 12.00 h during the light period, matured at 29-30 days of age, but it altered in phase afterwards.…”

Section: Discussionsupporting

confidence: 92%

“…Daily rhythms in the concentrations of prolactin [5,25], estradiol [20], and progesterone [6,24] in serum have also been re ported in the immature rat, but the development of these rhythms has received little attention. Luteinizing hormone (LH) secretion was pulsatile around 2 weeks of age, fol lowed by no rhythmic changes afterwards, and no rhythms in the follicle-stimulating hormone (FSH) level were found [5],…”

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confidence: 99%

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Development of Orcadian Rhythms in Serum Hormone Levels in the Immature Female Rat

Kimura¹,

Okano²,

Kawakami³

1981

Neuroendocrinology

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Diurnal variations in concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), corticosterone, estradiol-17β and estrone in serum were investigated in 27- to 35-day-old female rats maintained on a 14-hour light and 10-hour dark schedule. Groups of 6–8 rats were decapitated at 3-hour intervals during a 24-hour period. Hormones were measured by radioimmunoassay. LH levels were highly variable over a 24-hour period in rats younger than 32–33 days of age, while in 34- to 35-day-old animals the levels were less variable and a moderate LH peak was seen at 24.00 h. A distinct FSH diurnal rhythm with the peak at 15.00 h was demonstrated in rats older than 32 days of age. The 27- to 28-day-old rat had a diurnal TSH rhythm with the peak at 12.00 h, but older rats had a rhythm with two peaks at 24.00 and 9.00 h. The diurnal corticosterone rhythm analogous to the adult’s was established at 32 days of age, although a significant variation having a peak during the dark period appeared earlier. Similarly, a distinct estradiol rhythm appeared at 29 days of age with the peak at 12.00 h, followed by a change in the peak phase afterwards. Serum estrone levels showed a manifest variation in the 27- to 28-day-old rat, but no variation was observed in the older rats. These results not only confirm the previous reports on the existence of pulsatile LH secretion, and corticosterone and estradiol diurnal rhythms, but also demonstrate the existence of diurnal rhythms in FSH, TSH and estrone levels in the immature female rat. Furthermore, it is possible that the rhythm once developed may change in phase, or even disappear as puberty approaches.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Development of Orcadian Rhythms in Serum Hormone Levels in the Immature Female Rat

Kimura¹,

Okano²,

Kawakami³

1981

Neuroendocrinology

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“… 74 Strong circadian pattern in serum estradiol (E2) with a peak during end of the dark phase was reported for female rats. 75 Serum corticosterone was reported to have circadian oscillation in rats in both sexes with a peak during transition from light to dark phase of the day; however the amplitude was 3 times larger in female rats. 76 Indeed, we have outlined the contribution of hormone signaling to the dimorphism in rhythmicity ( Table 1 ; Figures 11 and 12 ).…”

Section: Discussionmentioning

confidence: 99%

Sexual dimorphism of circadian liver transcriptome

Astafev,

Mezhnina,

Poe

et al. 2024

iScience

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“…Many investigators have studied the onset of puberty in rats and have shown a relationship between vaginal opening and gonadotrophin release (Ramirez, 1973). According to Nelson, Cullin & Hoffmann (1978) and Ramaley (1979), vaginal opening is useful for the determination of puberty in rats but does not always correspond to the time of the first oestrus.…”

Section: Introductionmentioning

confidence: 99%

Timing of sexual receptivity and the release of gonadotrophins during puberty in female rats

Hashizume¹,

Ohashi²

1984

Reproduction

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Circadian Rhythms of Serum Estradiol and Corticosterone and Related Organ Weight Changes in the Prepubertal Female Rat

Cited by 8 publications

References 22 publications

Development of Orcadian Rhythms in Serum Hormone Levels in the Immature Female Rat

Development of Orcadian Rhythms in Serum Hormone Levels in the Immature Female Rat

Sexual dimorphism of circadian liver transcriptome

Timing of sexual receptivity and the release of gonadotrophins during puberty in female rats

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