Circadian rhythms on hypothalamic–pituitary–adrenal axis hormones and cytokines of collagen induced arthritis in rats

Li, Shao; Lu, Aiping; Li, Biao; Wang, Yongyan

doi:10.1016/j.jaut.2004.03.001

Cited by 22 publications

(21 citation statements)

References 40 publications

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“…We estimated the TNF-α, IL-6, and IL-1β concentrations in plasma at different times in the present study. IL-1β was undetectable in plasma in almost all mice both before and after immunization as was reported in past studies using CIA model mice (35,36). On the other hand, the TNF-α and IL-6 concentrations were significantly higher than those in normal mice at all sampling times.…”

Section: Discussionsupporting

confidence: 80%

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Dosing Time–Dependency of the Arthritis-Inhibiting Effect of Tacrolimus in Mice

et al. 2011

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Abstract. Stiffness and cytokine in blood levels show 24-h rhythms in rheumatoid arthritis (RA) patients. We previously revealed that higher therapeutic effects were obtained in RA patients and RA model animals when the dosing time of methotrexate was chosen according to the 24-h rhythms to cytokine. In this study, we examined whether a dosing time-dependency of the therapeutic effect of tacrolimus (TAC) could be detected in collagen-induced arthritis (CIA) and MRL/lpr mice. To measure the levels of cytokines and serum amyloid A (SAA), blood was collected from CIA mice at different times. TAC was administered at two different dosing times based on these findings and its effects on arthritis and toxicity were examined. Plasma tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), and SAA concentrations showed obvious 24-h rhythms with higher levels during the light phase and lower levels during the dark phase after RA crisis. The arthritis score and leukocyte counts were significantly lower in the group treated at 2 h after the light was turned on (HALO) than in the control and 14 HALO-treated groups. Our findings suggest that choosing an optimal dosing time could lead to the effective treatment of RA by TAC.

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Section: Discussionsupporting

confidence: 80%

“…These results did not correspond to the dosing time-dependency of the inhibitory effect of TAC on arthritis. Cytokines are hard to detect in plasma despite the fact that high levels of cytokines can be measured in tissue in CIA and adjuvant-induced arthritis animals (35,36).…”

Section: Discussionmentioning

confidence: 99%

Dosing Time–Dependency of the Arthritis-Inhibiting Effect of Tacrolimus in Mice

et al. 2011

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“…It is an extensively studied form of experimental arthritis aimed to provide careful information on the characterization of immunopathogenic mechanisms and the nature of autoreactivity [18]. Continued investigation of the CIA model can be expected to yield important information that can be used to better understand its human counterparts.…”

Section: Discussionmentioning

confidence: 99%

“…CIA was initiated in 33 Wistar and 31 Lewis rats via the footpad method [17,18] under light anaesthesia with Apaurin. The animals of both strains were divided randomly into three test groups of 5-6 male or 5-8 female rats in each.…”

Section: Collagen Arthritis Inductionmentioning

confidence: 99%

Kolagenu sukeltas Wistar ir Lewis žiurkių artritas ir (Pro-)antioksidantinės sistemos būklė

Leonavičienė¹,

Bradūnaitė²,

Vaitkienė³

et al. 2008

Biologija

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The aim of this study was to investigate the development of collagen-induced arthritis (CIA) in male and female Wistar and Lewis rats and establish relationships between clinical status and the levels of serum oxidative products. CIA was induced in 64 rats divided randomly into three groups. Animals of the 1st group received one 0.1 ml injection of bovine type II collagen (CII, in dose of 0.1 mg/rat) emulsified in incomplete Freund's adjuvant (IFA). Rats of the 2nd group were immunized twice: on day 0 (dose of CII 0.1 mg/rat) and day 7 (dose of CII 0.05 mg/rat), and the animals of the 3rd group received one 0.1 ml injection of emulsion consisting of CII (0.1 mg/rat) in IFA and muramyldipeptide (MDP, in dose of 3 mg/ml). Serum oxidative products such as malondialdehyde (MDA), anti-oxidative enzyme catalase (CAT), total antioxidant activity (AOA), and arthritic profiles based on paw swelling, development of polyarthritis and histological changes in joints were measured in rats with CIA. Our findings have demonstrated that CIA develops in both sexes of Wistar and Lewis rats and the disease that occurs is an inflammatory erosive arthritis. Examination of the clinical course of the disease and the subsequent histological analysis disclosed a slight less aggressive disease in Wistar than in Lewis rats and in female than in male animals. The most severe arthritis developed in the 3rd group of male Lewis rats. CIA induced significant changes in the parameters of the pro-/antioxidant status of serum. Comparison of the oxidative statuses of both strains of rats with CIA and those of healthy animals revealed more elevated MDA levels in the serum of Wistar than Lewis rats. More evidently in the serum of these rats the level of total AOA was reduced, especially in the 3rd group of animals. More susceptible to CIA, Lewis rats showed a lower MDA production as compared with Wistar animals, and the lowest CAT activity in the serum of these rats was observed. In conclusion, attenuated inflammatory response and pathomorphological changes in joints were more observed in female animals of both strains. Male Lewis rats were most susceptible to CIA. On the basis of increased lipid peroxidation and decreased levels of AOA and enzyme CAT activity, CIA rats are subject to oxidative stress.

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“…Certain proangiogenic and antiangiogenic plant components have been used in TCM for thousands of years, and TCM Fu-Fang is believed to be potentially useful and well tolerated for curing angiogenesis disorders such as rheumatoid arthritis [63]. Li et al [64] identified the suppressive effects of a Cold-natured Fu-Fang, QingLuo-Yin (QLY) extracts, on the angiogenesis of CIA rats, an animal model with both NEI dysfunction [65,66] and angiogenesis [67]. QLY is composed of four Cold-natured herbs and aims to expel the "pathogenetic Hot" for curing Hot ZHENG-related RA.…”

Section: Synergistic Effect Of Tcm Fu-fangmentioning

confidence: 99%

Network Systems Underlying Traditional Chinese Medicine Syndrome and Herb Formula

2009

CBIO

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Traditional Chinese Medicine (TCM) is characterized by regulating the integrity of the human body and has accumulated thousand-year experience in the use of Herb Formula ("Fu-Fang" in Chinese) for managing complicated TCM Syndrome ("ZHENG" in Chinese). In recent years, there has been increasing concern about the application of bioinformatics and systems biology approaches for deciphering the scientific basis and the systematic features of TCM. Based on the new trends in such an interdisciplinary field, which we termed TCM systems bioinformatics (TCMSB), we propose for the first time a map of "Phenotype network-Biological network-Herb network" with an attempt to uncover the network systems underlying, and identify network biomarkers for, TCM Syndrome and Herb Formula. This multilayer map can serve as a start point towards the systematic interpretation of TCM theory and practice, and give promise to bridge the gap between the ancient TCM and the coming systems biology-based medicine in both system and molecular levels. Moreover, TCMSB approaches, which combine the use of computational modeling and experimental studies, may not only help catch the traditional features of TCM in view of complex biological systems and lead to the step by step modernization for TCM, but may also educe new concept for the future integrative medicine and systems medicine.

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Circadian rhythms on hypothalamic–pituitary–adrenal axis hormones and cytokines of collagen induced arthritis in rats

Cited by 22 publications

References 40 publications

Dosing Time–Dependency of the Arthritis-Inhibiting Effect of Tacrolimus in Mice

Dosing Time–Dependency of the Arthritis-Inhibiting Effect of Tacrolimus in Mice

Kolagenu sukeltas Wistar ir Lewis žiurkių artritas ir (Pro-)antioksidantinės sistemos būklė

Network Systems Underlying Traditional Chinese Medicine Syndrome and Herb Formula

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