Circadian system microRNAs – Role in the development of cardiovascular diseases

Škrlec, Ivana

doi:10.1016/bs.apcsb.2023.02.004

Cited by 3 publications

(3 citation statements)

References 135 publications

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“…Through this domain, it dimerizes with BMAL1 and stimulates the expression of target genes. Thus, HIF1α serves as a molecular link between oxygen levels and the circadian rhythm[ 13 ].…”

Section: Hif1α and The Circadian Rhythm In Myocardial Infarctionmentioning

confidence: 99%

“…HIF1α is associated with vascular inflammation and the progression of atherosclerosis, whereas CLOCK and BMAL1 can also promote HIF1α expression[ 1 ]. Furthermore, myocardial ischemia triggers pathways to improve oxygen delivery and, during hypoxia, PER2 interacts with HIF1α[ 13 ]. This occurs because PER2 stabilizes HIF1α via adenosine receptor A2B (ADORA2B), which is crucial for myocardial adaptation to hypoxia[ 14 ].…”

Section: Hif1α and The Circadian Rhythm In Myocardial Infarctionmentioning

confidence: 99%

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Hypoxia-inducible factor-1α in myocardial infarction

Škrlec,

Kolomeichuk

2024

World J Cardiol

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Hypoxia-inducible factor 1 (HIF1) has a crucial function in the regulation of oxygen levels in mammalian cells, especially under hypoxic conditions. Its importance in cardiovascular diseases, particularly in cardiac ischemia, is because of its ability to alleviate cardiac dysfunction. The oxygen-responsive subunit, HIF1α, plays a crucial role in this process, as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival, angiogenesis, and metabolism. Furthermore, HIF1α expression induced reperfusion in the ischemic skeletal muscle, and hypoxic skin wounds in diabetic animal models showed reduced HIF1α expression. Increased expression of HIF1α has been shown to reduce apoptosis and oxidative stress in cardiomyocytes during acute myocardial infarction. Genetic variations in HIF1α have also been found to correlate with altered responses to ischemic cardiovascular disease. In addition, a link has been established between the circadian rhythm and hypoxic molecular signaling pathways, with HIF1α functioning as an oxygen sensor and circadian genes such as period circadian regulator 2 responding to changes in light. This editorial analyzes the relationship between HIF1α and the circadian rhythm and highlights its significance in myocardial adaptation to hypoxia. Understanding the changes in molecular signaling pathways associated with diseases, specifically cardiovascular diseases, provides the opportunity for innovative therapeutic interventions, especially in low-oxygen environments such as myocardial infarction.

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“…Through this domain, it dimerizes with BMAL1 and stimulates the expression of target genes. Thus, HIF1α serves as a molecular link between oxygen levels and the circadian rhythm[ 13 ].…”

Section: Hif1α and The Circadian Rhythm In Myocardial Infarctionmentioning

confidence: 99%

Section: Hif1α and The Circadian Rhythm In Myocardial Infarctionmentioning

confidence: 99%

Hypoxia-inducible factor-1α in myocardial infarction

Škrlec,

Kolomeichuk

2024

World J Cardiol

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“…This pleiotropic hormone has several different functions [4], but regulating circadian rhythm, including sleep and wakefulness, is considered the most important one [5]. Previous studies confirmed its fundamental antioxidant effects since it scavenges free radicals and stimulates antioxidant enzymes and molecules to prevent radicals [6,7], besides having antiinflammatory and possibly epigenetic regulatory functions [8][9][10]. Melatonin's circadian rhythm of secretion [11], through increased secretion during the night and decreased secretion during the day, coordinates physiological processes and behavioral activities [2,3].…”

Section: Introductionmentioning

confidence: 99%

Myocardial Infarction Susceptibility and the MTNR1B Polymorphisms

Škrlec

Biloglav

Talapko

et al. 2023

IJMS

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Melatonin is a circadian hormone with antioxidant properties that protects against myocardial ischemia-reperfusion injury. Genetic variations of the melatonin receptor 1B gene (MTNR1B) play an important role in the development of type 2 diabetes, a risk factor for cardiovascular diseases. Accordingly, MTNR1B polymorphisms are crucial in numerous disorders of the cardiovascular system. Therefore, the aim of the present study was to investigate a possible association of MTNR1B polymorphisms with chronotype and susceptibility to myocardial infarction. The present case-control study included 199 patients with myocardial infarction (MI) (57% men) and 198 control participants (52% men) without previous cardiovascular diseases who underwent genotyping for the MTNR1B polymorphisms rs10830963, rs1387153, and rs4753426 from peripheral blood samples. Chronotype was determined using the Morningness-Eveningness Questionnaire (MEQ). As estimated by the chi-square test, no significant association was found in the distribution of alleles and genotypes between myocardial infarction patients and controls. In addition, there was no association between MTNR1B polymorphisms and chronotype in MI patients. As some previous studies have shown, the present negative results do not exclude the role of the MTNR1B polymorphisms studied in the development of myocardial infarction. Rather, they may indicate that MTNR1B polymorphisms are a minor risk factor for myocardial infarction.

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Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities

Abdel Mageed,

Elimam,

Elesawy

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Gouty arthritis is a prevalent inflammatory illness. Gout attacks begin when there is an imbalance in the body’s uric acid metabolism, which leads to urate buildup and the development of the ailment. A family of conserved, short non-coding RNAs known as microRNAs (miRNAs) can regulate post-transcriptional protein synthesis by attaching to the 3′ untranslated region (UTR) of messenger RNA (mRNA). An increasing amount of research is pointing to miRNAs as potential players in several inflammatory diseases, including gouty arthritis. miRNAs may influence the progression of the disease by regulating immune function and inflammatory responses. This review mainly focused on miRNAs and how they contribute to gouty arthritis. It also looked at how miRNAs could be used as diagnostic, prognostic, and potential therapeutic targets.

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Circadian system microRNAs – Role in the development of cardiovascular diseases

Cited by 3 publications

References 135 publications

Hypoxia-inducible factor-1α in myocardial infarction

Hypoxia-inducible factor-1α in myocardial infarction

Myocardial Infarction Susceptibility and the MTNR1B Polymorphisms

Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities

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