Circadian variation in hematotoxicity of the antineoplastic agent “5 Fluorouracil (5 FU)” in female rats and its relevance to chronotherapy

Bouali, Inès; Dridi, Ichrak; Gadacha, Wafa; Aouam, Karim; Hassine, Mohsen; El-Bok, Safia; Boughattas, Naceur A.; Ben‐Attia, Mossadok; Zaeid, Sonia; Souli, Abdelaziz

doi:10.1080/09291016.2023.2206088

Biological Rhythm Research

2023

DOI: 10.1080/09291016.2023.2206088

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Circadian variation in hematotoxicity of the antineoplastic agent “5 Fluorouracil (5 FU)” in female rats and its relevance to chronotherapy

Inès Bouali

Ichrak Dridi

Wafa Gadacha

et al.

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Chronotoxicity Studies in Pharmaceutical Science: A Comprehensive Review

Güdül,

Kordbacheh,

Sanajou

et al. 2024

EMU Journal of Pharmaceutical Sciences

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Chronotoxicity evaluates the time-dependent toxicity of xenobiotics together with an individual’s circadian rhythm. Suprachiasmatic nuclei located in the hypothalamus regulate circadian rhythms in individuals. Circadian rhythms are important for human health, metabolic processes, inflammation, and various cancers. This comprehensive review aims to provide an overview of the literature on chronotoxicity, circadian pharmacokinetics, and chronoefficiency. Our literature search was conducted using databases including “Web of Science,” “PubMed,” and “Science Direct.” We used the keywords “circadian rhythm dysregulation,” “chronotoxicity of therapeutics,” “chronotoxicity,” and “time-dependent toxicity” for our literature search. Chronopharmacokinetics studies pharmacokinetic changes related to dosage time. Light plays an important role in circadian rhythm by stimulating ganglion cells. The stimulus is transferred to the suprachiasmatic nuclei and other parts of the brain that regulate the circadian rhythm. Evaluation of the risks and benefits of various therapeutic options requires detailed knowledge of the complex mechanisms that regulate circadian rhythms.

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Chronotoxicity Studies in Pharmaceutical Science: A Comprehensive Review

Güdül,

Kordbacheh,

Sanajou

et al. 2024

EMU Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Circadian variation in hematotoxicity of the antineoplastic agent “5 Fluorouracil (5 FU)” in female rats and its relevance to chronotherapy

Cited by 1 publication

References 61 publications

Chronotoxicity Studies in Pharmaceutical Science: A Comprehensive Review

Chronotoxicity Studies in Pharmaceutical Science: A Comprehensive Review

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