Circadian variation of symptomatic paroxysmal atrial fibrillation. Data from almost 10000 episodes

Viskin, Sami; Golovner, Michal; Malov, Nomi; Fish, Roman; Alroy, I; Vila, Y.; Laniado, Shlomo; Kaplinsky, Elieser; Roth, Arie

doi:10.1053/euhj.1999.1632

Cited by 96 publications

(60 citation statements)

References 19 publications

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“…This reduction was most apparent in the early morning, when the incidence of AF is highest. 154 Histologically, LL-VNS resulted in a significant reduction of ganglion cells in the LSG that were stained positive for tyrosine hydroxylase, an enzyme critical in the biosynthesis of adrenalines ( Figure 8A). A subsequent study by the same group showed that in the LSG, LL-VNS also resulted in the upregulation of small-conductance calcium-activated potassium channel type 2 and increased its expression in the cell membrane ( Figure 8B and 8C).…”

Section: Neural Stimulationmentioning

confidence: 99%

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

Shen

Zipes

2014

Circulation Research

701

543

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I n 1628, William Harvey hinted at a link between the brain and the heart when he wrote, "For every affection of the mind that is attended with either pain or pleasure, hope or fear, is the cause of an agitation whose influence extends to the heart."1 For the past half century, numerous anatomic and physiological studies of cardiac autonomic nervous system (ANS) 2-6 have investigated this link and found it to be very complex. Autonomic activation alters not only heart rate, conduction, and hemodynamics, but also cellular and subcellular properties of individual myocytes. The characterization of extrinsic cardiac ANS and intrinsic cardiac ANS ranges from the recognition of anatomic relationships at the gross level to discovery of chemoreceptors, mechanoreceptors, and intracardiac ganglia lining specific regions along the cardiac chambers and great vessels. Moreover, studies beginning >80 years ago [7][8][9] have demonstrated the critical role of cardiac ANS in cardiac arrhythmogenesis. This topic has garnered much recent interest because of mounting evidence showing that neural modulation either by ablation or stimulation can effectively control a wide spectrum of cardiac arrhythmias. [10][11][12][13] In this review, we will briefly discuss the anatomic aspects of cardiac ANS, focusing on how autonomic activities influence cardiac electrophysiology. We will also discuss specific autonomic triggers of various cardiac arrhythmias, including atrial fibrillation (AF), ventricular arrhythmias, and inherited arrhythmia syndromes. Lastly, we will discuss the latest avenues of research and clinical trials regarding the application of neural modulation in the treatment of specific cardiac arrhythmias.

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Section: Neural Stimulationmentioning

confidence: 99%

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

Shen

Zipes

2014

Circulation Research

701

543

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“…The study conducted on a large population (32,992) in Denmark revealed a noticeable increase in the incidence of AF episodes in winter, a decrease in summer as well as an association between these episodes and outdoor temperature (Frost et al 2002). Similarly, two studies on the seasonality of paroxysmal AF, in Israel (Viskin et al 1999) and Finland (Kupari and Koskinen 1990), found the peak incidence during winter despite the fact that the average temperatures in both countries vary considerably. On the other hand, according to findings from one Japanese study, the incidence of AF paroxysms was the highest in autumn and the lowest in summer (Watanabe et al 2007).…”

mentioning

confidence: 92%

May Sunshine Protect Women Against Paroxysms of Atrial Fibrillation?

Głuszak¹,

Kocoń

Szaniawska

et al. 2009

Tohoku J. Exp. Med.

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“…Viskin et al showed circadian variation in the incidence of symptomatic AF in humans, an observation that indicated the importance of the ANS in atrial arrhythmogenesis. 13 In the study by Tatsuishi et al 2 in this issue of the Journal, in addition to BS, another significant, and potentially independent risk factor of post-CABG AF was postoperative drainage volume. However, the focus of that study was the relationship between BS and AF, and drainage volume was not assessed further.…”

Section: Article P 112mentioning

confidence: 94%

Postoperative High Blood Glucose

Chishaki

2014

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp the chronic effects of hyperglycemia, but the results are conflicting. In a survey of hospitalized patients, AF occurred in 14.9% of those with DM compared with 10.3% in the control group made up of patients with hypertension but not DM. 4 The Framingham Study identified DM as an independent risk factor for AF. 5 Iguchi et al reported that among 41,436 residents of a Japanese city, the prevalence of DM was higher in those with than without AF (20% vs. 12%) and the multivariate analysis reported that DM was independently associated with AF. 6 However, in the development of risk score for AF using the data from the Framingham cohort, DM was not a significant predictor. 7 Thus, the mechanisms that cause AF seem to be complex and likely reflect the interactions of multiple factors such as in metabolic syndrome, depending on the underlying pathology and other patient-related factors. 8 Moreover, some studies have questioned whether DM is a direct cause of AF while acknowledging the positive correlation between them. In the large cohort study of 34,720 females carried out by Schoen et al, there was a significant relationship between DM and the incidence of AF, but most of the increased risk attributed to trial fibrillation (AF) is one of the most common complications of coronary artery bypass grafting (CABG) and a major cause of concern because of its association with an increased risk of thromboembolic events. 1 In addition, AF can lead to hemodynamic compromise in response to the loss of effective atrial contraction during ventricular diastole and an irregular and abnormal ventricular filling time. Article p 112Patients recovering from major surgery, such as CABG, are affected by a unique set of factors that may contribute to AF and are clearly very different from the stress factors of daily life ( Figure). In a retrospective study of 199 consecutive CABG patients, Tatsuishi et al found a positive correlation between high postoperative blood sugar concentration (BS) and a higher incidence of post-CABG AF. 2 Diabetes mellitus (DM) is one of the most common concomitant diseases in patients with AF. 3 Many epidemiological studies have examined the risk of AF in relation to DM and AThe opinions expressed in this article are not necessarily those of the editors or of the Japanese Circulation Society.

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Circadian variation of symptomatic paroxysmal atrial fibrillation. Data from almost 10000 episodes

Cited by 96 publications

References 19 publications

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

May Sunshine Protect Women Against Paroxysms of Atrial Fibrillation?

Postoperative High Blood Glucose

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