Circadian Variation of the Plasma 17-Hydroxycorticosteroids in Central Nervous System Disease1

Krieger, D. T.; Krieger, Howard P.

doi:10.1210/jcem-26-9-929

Cited by 70 publications

(18 citation statements)

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“…1 and 2.) The children's pattern for cortisol secretion followed the adult pattern except that the elevation of cortisol at 0600 hours was more pronounced than for adults (Kreiger & Kreiger, 1966;Luce, 1970). This finding may indicate that the cerebro-hypothalamic system is not yet as finely tuned as in adulthood or that cortisol secretion in children is influenced by their greater output of growth hormone during deep sleep.…”

Section: Resultsmentioning

confidence: 89%

Diurnal cortisol and temperature variation of normal and autistic children

Hill

Wagner

Shedlarski

et al. 1977

Developmental Psychobiology

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Section: Resultsmentioning

confidence: 89%

Diurnal cortisol and temperature variation of normal and autistic children

Hill

Wagner

Shedlarski

et al. 1977

Developmental Psychobiology

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“…The circadian pattern of cortisol secretion is firmly fixed in the man and does not change even during most of chronic conditions (P insker and Bultasová 1979). Exceptions can be found in cases of some pathological conditions affecting the hypothalamus, and/or impairing consciousness or sleep (Krieger and Krieger 1966). Circadian rhythm of cortisol secretion is affected in most patients with Cushing's syndrome.…”

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confidence: 99%

Circadian Rhythm of Cortisol Secretion in Dogs of Different Daily Activities

Kolevská¹,

Brunclík²,

Svoboda³

2003

Acta Vet. Brno

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The concentrations of immunoreactive cortisol were monitored over 24 hours in the serum of a total of 23 dogs. The dogs were divided into three groups: (a) control group with no exercise, (b) experimental group, (c) working dogs. Blood was collected from each dog at the intervals of 90-180 min. The cortisol concentrations in different time periods were mutually compared using the Kruskal-Wallis test for the analysis of variance. Circadian pattern was found in the study. Cortisol concentrations found between 10.00 and 13.00 (46.5 ± 17.0 nmol/l) were significantly higher (P < 0.05) than those found between 19.00 and 22.00 (38.9 ± 16.0 nmol/l). The results differed within individual groups. Diurnal rhythms were confirmed in control group but not found in experimental group and in working dogs. In experimental group, other significant (P < 0.05) differences were also found between various time intervals compared to the total pattern but no diurnal rhythm was established. In working dogs no significant differences (P < 0.05) were found between cortisol concentrations in different time intervals. The results suggest that cortisol concentrations in the dog are subject to considerable changes during the day. Depending on the characteristics of day and night activities a diurnal rhythm can be found in some dogs.

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“…Additionally, a normal nycterohemeral variation of the plasma 11-OHCS level was found in all the subjects according to the criteria by Krieger and Krieger (1966) and Krieger et al (1971). Thus, a normal pattern is defined as one in which all plasma 11-OHCS levels after 8 a.m. are less than 75 % of the 8 a.m. level, with the exception of the noon level, which should not exceed the 8 a.m. value by more than 15 %.…”

Section: Nycterohemeral Rhythmmentioning

confidence: 85%

Serum Immunoreactive Corticotrophin and Response to Metyrapone in Old Age in Man

Blicher-Toft¹,

Hummer²

1977

Gerontology

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Attempts have been made to establish the level of immunoreactive corticotrophin (IR-ACTH) in serum in healthy subjects with particular reference to the results in old age. A total of 146 subjects were investigated and the clinical and biochemical conditions of selection specified. Serum IR-ACTH was determined by a radioimmunoassay procedure using an N-terminal antibody produced against the 1–24 sequence of the corticotrophin molecule. The morning level of serum IR-ACTH was determined in 115 fasting healthy subjects, range < 16–210 pg/ml, median 94 pg/ml (3rd International Standard preparation). The level was found to be unchanged within the age interval 20–94 years, irrespective of sex. The nycterohemeral variation of the IR-ACTH concentration in serum was studied in 11 subjects. A rhythmic variation of the IR-ACTH level was not constantly found and age-related difference in the temporal pattern was not demonstrated. In 10 young and 10 elderly subjects a metyrapone test was carried out and the IR-ACTH response was determined. The rise in serum IR-ACTH concentration varied between 20 and 739 pg/ml. Any significant age-related difference in response was not found. The interpretation of the present results with respect to the decreased secretory activity of the glucocorticoid producing system in the aged is discussed. It was concluded that the findings in this study did not indicate a primary deficiency of the axis of the glucocorticoid producing system, neither at the pituitary level nor at the adrenocortical level, as a causal factor to the decreased glucocorticoid production in old age.

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Circadian Variation of the Plasma 17-Hydroxycorticosteroids in Central Nervous System Disease1

Abstract: Only 6 of 49 hands with Dupuytren's contracture not ini¬ tially treated and followed for one to six years required operation. An early or aggressive approach to treatment is not warranted with the single exception of contracture at the proximal interphalangeal joint.

Cited by 70 publications

References 0 publications

Diurnal cortisol and temperature variation of normal and autistic children

Diurnal cortisol and temperature variation of normal and autistic children

Circadian Rhythm of Cortisol Secretion in Dogs of Different Daily Activities

Serum Immunoreactive Corticotrophin and Response to Metyrapone in Old Age in Man

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