Circadian variations of histamine binding to lymphocytes and neutrophils and skin reactivity to histamine in atopic and healthy subjects

Zak-Nejmark, T; Nowak, Iwona; Kraus-Filarska, M

doi:10.1007/s00005-006-0032-0

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…In healthy humans, plasma levels of beta-endorphins (but not of histamine ( 454 )) show rhythmic regulation being highest in the morning and reduced in the night ( 455 – 457 ). Ligand binding to histamine receptors on leukocytes likewise changes from night to day with complex patterns in healthy and atopic individuals ( 458 ). Moreover, in healthy individuals blood levels of cortisol and beta-endorphins are coupled, meaning that cortisol follows beta-endorphin with a lag-phase of ten minutes ( 459 ).…”

Section: Candidate Neuroendocrine Mediators Linking Shift Work With S...mentioning

confidence: 99%

Potential effects of shift work on skin autoimmune diseases

2023

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Shift work is associated with systemic chronic inflammation, impaired host and tumor defense and dysregulated immune responses to harmless antigens such as allergens or auto-antigens. Thus, shift workers are at higher risk to develop a systemic autoimmune disease and circadian disruption with sleep impairment seem to be the key underlying mechanisms. Presumably, disturbances of the sleep-wake cycle also drive skin-specific autoimmune diseases, but epidemiological and experimental evidence so far is scarce. This review summarizes the effects of shift work, circadian misalignment, poor sleep, and the effect of potential hormonal mediators such as stress mediators or melatonin on skin barrier functions and on innate and adaptive skin immunity. Human studies as well as animal models were considered. We will also address advantages and potential pitfalls in animal models of shift work, and possible confounders that could drive skin autoimmune diseases in shift workers such as adverse lifestyle habits and psychosocial influences. Finally, we will outline feasible countermeasures that may reduce the risk of systemic and skin autoimmunity in shift workers, as well as treatment options and highlight outstanding questions that should be addressed in future studies.

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Section: Candidate Neuroendocrine Mediators Linking Shift Work With S...mentioning

confidence: 99%

Potential effects of shift work on skin autoimmune diseases

2023

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“…Cutaneous immune responses to allergens differ throughout the day, e.g., Reinberg et al (1965) observed that there is a circadian variation to the reactivity to skin tests. Zak-Nejmark et al (2006) et al studied skin reactivity of healthy and atopic individuals to histamine and observed that healthy individuals have the lowest reactivity at night. In contrast atopic individuals exhibit the highest reactivity at night.…”

Section: Functional Chronobiological Rhythms Of the Skinmentioning

confidence: 99%

Chronobiology of the Skin: Cutaneous Clocks and Biorhythms

Mehling¹,

Reymermier²

2015

Measuring the Skin

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Chronobiology, the science of temporal rhythms in biological systems, is a relatively new field. Biological clocks coordinate our physiological and behavioral functions and interactions with our environment. Based on the sun as our primary external synchronizer, the circadian rhythm is probably the most pronounced biorhythm influencing our daily functions. Insights into this field have revealed numerous endogenous clocks composed of an intricate network of regulatory feedback loops, the complexity of which is currently little understood. Biological clocks can also be found on the cellular level, with the genes aptly termed period, timeless, clock, etc. In this chapter, examples of chronobiological rhythms, primarily circadian rhythms, found in the skin on both the functional and cellular levels will be described.

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Chronobiology of the Skin: Cutaneous Clocks and Biorhythms

Mehling¹,

Reymermier²

2017

Agache's Measuring the Skin

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Circadian variations of histamine binding to lymphocytes and neutrophils and skin reactivity to histamine in atopic and healthy subjects

Cited by 4 publications

References 19 publications

Potential effects of shift work on skin autoimmune diseases

Potential effects of shift work on skin autoimmune diseases

Chronobiology of the Skin: Cutaneous Clocks and Biorhythms

Chronobiology of the Skin: Cutaneous Clocks and Biorhythms

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