Circadian variations of rectal cell proliferation in patients affected by advanced colorectal cancer

Brandi, Giovanni; Calabrese, Carlo; Pantaleo, Maria Abbondanza; Morselli-Labate, Antonio Maria; Febo, Giulio Di; Hakim, Rossella; Vivo, Antonio De; Marco, Mariacristina Di; Biasco, Guido

doi:10.1016/j.canlet.2003.11.015

Cited by 19 publications

(10 citation statements)

References 15 publications

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“…Deregulation of the molecular clock is correlated with the loss of control in cell proliferation, metabolism, DNA replication and repair, senescence, apoptosis, DNA damage response and increased drug resistance in all types of human cancer cells studied (Table 1) 68,78,83,88,94,96,98,99,101–107 .…”

Section: Circadian Dysfunction Promotes Cancer Development In Humansmentioning

confidence: 99%

“…The uncoupling of mitotic rhythm between normal host tissue and metastasizing cancer was first reported in 1940 190 . It is now well-known that cell proliferation in all rapidly renewing mammalian tissues studied follow a diurnal oscillating rhythm under normal physiological conditions but is altered in tumors 78,101,191–197 . The coupling of cell proliferation rhythm between host and tumor has been observed in slow-growing tumors that show considerably higher levels of DNA synthesis and mitotic indices than host tissues throughout a 24 hour period 197–199 .…”

Section: The Role Of the Mammalian Circadian Clock In Tumor Suppressionmentioning

confidence: 99%

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The Circadian Clock in Cancer Development and Therapy

Kettner

2013

Progress in Molecular Biology and Translational Science

217

198

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Most aspects of mammalian function display circadian rhythms driven by an endogenous clock. The circadian clock is operated by genes and comprises a central clock in the brain that responds to environmental cues and controls subordinate clocks in peripheral tissues via circadian output pathways. The central and peripheral clocks coordinately generate rhythmic gene expression in a tissue-specific manner in vivo to couple diverse physiological and behavioral processes to periodic changes in the environment. However, as the world industrialized, activities that disrupt endogenous homeostasis with external circadian cues have increased. This change in lifestyle has been linked to increased risk of diseases in all aspects of human health, including cancer. Studies in humans and animal models have revealed that cancer development in vivo is closely associated with the loss of circadian homeostasis in energy balance, immune function and aging that are supported by cellular functions important for tumor suppression including cell proliferation, senescence, metabolism and DNA damage response. The clock controls these cellular functions both locally in cells of peripheral tissues and at the organismal level via extracellular signaling. Thus, the hierarchical mammalian circadian clock provides a unique system to study carcinogenesis as a deregulated physiological process in vivo. The asynchrony between host and malignant tissues in cell proliferation and metabolism also provides new and exciting options for novel anti-cancer therapies.

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Section: Circadian Dysfunction Promotes Cancer Development In Humansmentioning

confidence: 99%

Section: The Role Of the Mammalian Circadian Clock In Tumor Suppressionmentioning

confidence: 99%

The Circadian Clock in Cancer Development and Therapy

Kettner

2013

Progress in Molecular Biology and Translational Science

217

198

View full text Add to dashboard Cite

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“…Hence, chronodisruption of light could afford possible boulevards to tailor cancer deterrence strategies and management (Ben-Shlomo & Kyriacou 2010). Altered Biological Rhythm Research 717 circadian rhythm of cell division is renowned in advanced colon cancer patients characteristically showing the maximum proliferation activity in the morning and afternoon but with a very low rate at night (Brandi et al 2004). The proliferative trend is similar in spite of few minor differences.…”

Section: Cell Cycle Clocksmentioning

confidence: 99%

“…Altered rhythms of reactive oxygen species and their products and antioxidants (Andreazza et al 2010) Administration of antioxidants at appropriate phases Disordered immune rhythms caused by dysregulated sleep-wake cycles (Faraut et al 2013) Synchronization of sleep-wake cycles by bright light therapy/ melatonin treatment Disrupted rhythms in children with leukaemia (Lévi 2002) Chemotherapy in evening rather than morning Circadian variation in vasodilation and endothelial behaviour in breast cancer patients (Gupta et al 2012) Radiation therapy to the chest wall in the afternoon to decrease cardiac toxicity Modified rhythm of cell proliferation activity in the morning and afternoon in colon cancer patients with significantly low cell division rate in night (Brandi et al 2004) Administration of antiproliferative drugs at appropriate times of 24 h period Disordered cortisol rhythms in breast and colorectal patients (Sephton et al 2013) Synchronization of cortisol rhythms by suitable therapy Modified oral mucosal cell cycle rhythm in head and neck cancer patients (Bjarnason et al 2009) Morning radiotherapy is recommended rather than afternoon radiotherapy (nonetheless, depiction of cell proliferation rhythms on individual basis is warranted) Mucositis and dermatitis observed in head and neck cancer patients (attributable to radioresistant S phase acrophase after radiotherapy) (Shukla et al 2011) Cetuximab treatment at appropritate phases (late afternoon/evening) 722 P. Subramanian et al…”

Section: Couldmentioning

confidence: 99%

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Chronotherapy: a noteworthy focal point in the treatment of cancer?

Subramanian

Jayapalan

Hashim

2014

Biological Rhythm Research

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In mammalian systems including humans, DNA synthesis, cell cycle and mitotic index are circadian in nature. Disrupted circadian clock leads to disturbed cellular rhythms, metabolism and hormonal balance and is noticeably accountable for the uncontrolled cell division ultimately leading to cancer. About a decade ago, there are fewer evidences on the role of biological clock on tumorigenesis. Currently, a relationship between shift work and cancer, distinctively breast cancer in women and prostate cancer in men, distraction of sleep-wake cycles and augmentation of cancer development, oncostatic effects of melatonin (the internal zeitgeber of circadian system), bidirectional relationships of circadian and immune systems, the prospect of clock genes as tumour suppressors, inaccurate temporal management of oxidative stress and genotoxicity have been recounted, making the crucial role of circadian clock in carcinogenesis. This review critically evaluates present knowledge on circadian rhythms in relation to cancer and its management. The accumulating and coercing evidences could be valuable in formulating the rhythm-based therapy as a remarkable focal point in the management of cancer.

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Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver

Davidson

Straume

Block

et al. 2005

Intl Journal of Cancer

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Dividing cells, including human cancers, organize processes necessary for their duplication according to circadian time. Recent evidence has shown that disruption of central regulation of circadian rhythms can increase the rate at which a variety of cancers develop in rodents. To study circadian rhythms in liver tumors, we have chemically induced hepatocellular carcinoma in transgenic rats bearing a luciferase reporter gene attached to the promoter of a core circadian clock gene (Period 1). We explanted normal liver cells and hepatomas, placed them into short‐term culture, and precisely measured their molecular clock function by recording light output. Results show that isolated hepatocellular carcinoma is capable of generating circadian rhythms in vitro. Temporally restricting food availability to either day or night altered the phase of the rhythms in both healthy and malignant tissue. However, the hepatomas were much less sensitive to this signal resulting in markedly different phase relationships between host and tumor tissue as a function of mealtime. These data support the conclusion that hepatoma is differentially sensitive to circadian timing signals, although it maintains the circadian organization of the nonmalignant cells from which it arose. Because circadian clocks are known to modulate the sensitivity of many therapeutic cytotoxic targets, controlling mealtiming might be used to increase the efficacy of treatment. Specifically, meal and treatment schedules could be designed that take advantage of coincident times of greatest tumor sensitivity and lowest sensitivity of host tissue to damage. © 2005 Wiley‐Liss, Inc.

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Circadian variations of rectal cell proliferation in patients affected by advanced colorectal cancer

Cited by 19 publications

References 15 publications

The Circadian Clock in Cancer Development and Therapy

The Circadian Clock in Cancer Development and Therapy

Chronotherapy: a noteworthy focal point in the treatment of cancer?

Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver

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