Circadian variations of stellate ganglion nerve activity in ambulatory dogs

Jung, Byung Chun; Dave, Amish S.; Tan, Alex Y.; Gholmieh, Ghassan; Zhou, Shengmei; Wang, David C.; Akingba, A. George; Fishbein, Michael; Montemagno, Carlo; Lin, Shien Fong; Chen, Lan S.; Chen, Peng Sheng

doi:10.1016/j.hrthm.2005.09.016

Cited by 68 publications

(57 citation statements)

References 29 publications

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“…In 2006, Jung et al 46 pioneered the technique of continuously recording the activity of stellate ganglia in healthy dogs using implanted radiotransmitters for an average of 41.5 days. The results showed the feasibility of chronic cardiac nerve recordings and demonstrated a circadian variation of sympathetic outflow to the heart.…”

Section: Measuring Autonomic Nerve Activitiesmentioning

confidence: 99%

“…The results showed the feasibility of chronic cardiac nerve recordings and demonstrated a circadian variation of sympathetic outflow to the heart. 46 Multiple subsequent studies 30,[47][48][49][50][51] with direct nerve activity recordings in diseased animal models have provided insights into the understanding of the role of cardiac ANS in arrhythmogenesis.…”

Section: Measuring Autonomic Nerve Activitiesmentioning

confidence: 99%

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Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

Shen

Zipes

2014

Circulation Research

701

543

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I n 1628, William Harvey hinted at a link between the brain and the heart when he wrote, "For every affection of the mind that is attended with either pain or pleasure, hope or fear, is the cause of an agitation whose influence extends to the heart."1 For the past half century, numerous anatomic and physiological studies of cardiac autonomic nervous system (ANS) 2-6 have investigated this link and found it to be very complex. Autonomic activation alters not only heart rate, conduction, and hemodynamics, but also cellular and subcellular properties of individual myocytes. The characterization of extrinsic cardiac ANS and intrinsic cardiac ANS ranges from the recognition of anatomic relationships at the gross level to discovery of chemoreceptors, mechanoreceptors, and intracardiac ganglia lining specific regions along the cardiac chambers and great vessels. Moreover, studies beginning >80 years ago [7][8][9] have demonstrated the critical role of cardiac ANS in cardiac arrhythmogenesis. This topic has garnered much recent interest because of mounting evidence showing that neural modulation either by ablation or stimulation can effectively control a wide spectrum of cardiac arrhythmias. [10][11][12][13] In this review, we will briefly discuss the anatomic aspects of cardiac ANS, focusing on how autonomic activities influence cardiac electrophysiology. We will also discuss specific autonomic triggers of various cardiac arrhythmias, including atrial fibrillation (AF), ventricular arrhythmias, and inherited arrhythmia syndromes. Lastly, we will discuss the latest avenues of research and clinical trials regarding the application of neural modulation in the treatment of specific cardiac arrhythmias.

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Section: Measuring Autonomic Nerve Activitiesmentioning

confidence: 99%

Section: Measuring Autonomic Nerve Activitiesmentioning

confidence: 99%

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

Shen

Zipes

2014

Circulation Research

701

543

View full text Add to dashboard Cite

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“…Because the autonomic nervous system (ANS) activity regulates cardiac ion channel function, it is possible that specific ANS activity might be responsible for triggering cardiac arrhythmias in CHF. Our laboratory recently developed methods for continuous (24 h/day, 7 days/week) and direct recording from the stellate ganglion nerve activity (SGNA) in normal ambulatory dogs over several months (2). We hypothesized that the same techniques could be applied for continuous recording of vagal nerve activity (VNA) and that simultaneous SGNA and VNA recording in dogs with CHF would provide an insight into the neural mechanisms of cardiac arrhythmias.…”

mentioning

confidence: 99%

Left Stellate Ganglion and Vagal Nerve Activity and Cardiac Arrhythmias in Ambulatory Dogs With Pacing-Induced Congestive Heart Failure

Ogawa

Zhou

Tan

et al. 2007

Journal of the American College of Cardiology

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210

191

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The reduction of sympathovagal balance at night in ambulatory dogs was due to reduced sympathetic discharge rather than a net increase of vagal discharge. The tachybrady syndrome in CHF might be triggered by an intermittent short burst of SGNA that resulted in tachycardia and sinus node suppression. Simultaneous sympathovagal discharge is a cause of long PAT episodes. These data indicate that there is an association between the specific patterns of autonomic nerve discharges and cardiac arrhythmia during CHF.

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“…However, renal sympathetic nerve activity may be different from cardiac sympathetic nerve activity. To record cardiac sympathetic nerve activity directly, Jung et al [23] had performed chronic ambulatory nerve recordings from the stellate ganglia with DSI transmitters for an average of 7 weeks. He reported the feasibility of long-term cardiac nerve recordings and showed a circadian variation of sympathetic outflow from canine stellate ganglion.…”

Section: Extrinsic Cardiac Nervous Activitysympathetic and Parasympatmentioning

confidence: 99%