CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis

Zhu, Xuemei; Luo, Xishun; Long, Xiangkai; Jiang, Shiyu; Xie, Xinyang; Zhang, Qiqi; Wang, Haipeng

doi:10.1007/s10142-023-00990-9

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Reducing RBBP4 levels can hinder the growth and migration, and increase the apoptosis of HCT116 and SW620 colon cancer cells, and also suppress the Wnt/β-catenin pathway ( 12 ). Concurrently, knocking down RBBP4 also inhibits H3K27ac acetylation and HSPB8 gene transcription ( 118 ). Another study demonstrated that RBBP4 is a key target of protopanaxadiol (PPD), a major ginseng metabolite ( 119 ), suggesting its potential as a new diagnostic and therapeutic target for CRC.…”

Section: Expression and Function Of Rbbp4/7 In Diseasesmentioning

confidence: 99%

Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)

Zhan,

Yin,

et al. 2024

Int J Mol Med

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Histone chaperones serve a pivotal role in maintaining human physiological processes. They interact with histones in a stable manner, ensuring the accurate and efficient execution of DNA replication, repair and transcription. Retinoblastoma binding protein (RBBP)4 and RBBP7 represent a crucial pair of histone chaperones, which not only govern the molecular behavior of histones H3 and H4, but also participate in the functions of several protein complexes, such as polycomb repressive complex 2 and nucleosome remodeling and deacetylase, thereby regulating the cell cycle, histone modifications, DNA damage and cell fate. A strong association has been indicated between RBBP4/7 and some major human diseases, such as cancer, age-related memory loss and infectious diseases. The present review assesses the molecular mechanisms of RBBP4/7 in regulating cellular biological processes, and focuses on the variations in RBBP4/7 expression and their potential mechanisms in various human diseases, thus providing new insights for their diagnosis and treatment.

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Section: Expression and Function Of Rbbp4/7 In Diseasesmentioning

confidence: 99%

Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)

Zhan,

Yin,

et al. 2024

Int J Mol Med

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“…For example, CircAGO2 can bind and silence miR-1-3p, thereby upregulating the expression of RBBP4. RBBP4 can deacetylate histones in the HSPB8 promoter region and inhibit HSPB8 transcription, thereby promoting the proliferation and invasion of colorectal cancer cells [ 37 ]. In addition, cHP1BP3 can also bind and silence miR-1-3p, upregulate the expression of C1GALT1, and promote the proliferation and migration of bladder cancer cells [ 38 ].…”

Section: Production and Regulation Of Mir-1-3pmentioning

confidence: 99%

The important role of miR-1-3p in cancers

Dai,

Li,

et al. 2023

J Transl Med

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Cancer is a malignant tumor that seriously threatens human life and health. At present, the main treatment methods include surgical resection, chemotherapy, radiotherapy, and immunotherapy. However, the mechanism of tumor occurrence and development is complex, and it produces resistance to some traditional treatment methods, leading to treatment failure and a high mortality rate for patients. Therefore, exploring the molecular mechanisms of tumor occurrence, development, and drug resistance is a very important task. MiRNAs are a type of non-coding small RNA that regulate a series of biological effects by binding to the 3′-UTR of the target mRNA, degrading the mRNA, or inhibiting its translation. MiR-1-3p is an important member of them, which is abnormally expressed in various tumors and closely related to the occurrence and development of tumors. This article introduces miR-1-3p from multiple aspects, including its production and regulation, role in tumor occurrence and development, clinical significance, role in drug resistance, and approaches for targeting miR-1-3p. Intended to provide readers with a comprehensive understanding of the important role of miR-1-3p in tumors. Graphical Abstract

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Circular RNA circSP5 promotes liver metastasis of colorectal cancer via SP5-mediated BAMBI transcription

Zhi,

Gao,

Wang

et al. 2023

Funct Integr Genomics

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CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis

Cited by 5 publications

References 28 publications

Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)

Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)

The important role of miR-1-3p in cancers

Circular RNA circSP5 promotes liver metastasis of colorectal cancer via SP5-mediated BAMBI transcription

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