Circannual Rhythms and Interactions of Vitamin D Metabolites, Parathyroid Hormone, and Biochemical Markers of Skeletal Homeostasis: A Prospective Study

Woitge, Henning W.; Knothe, Antje; Witte, Klaus; Schmidt‐Gayk, H.; Ziegler, Reinhard; Lemmer, Björn; Seibel, Markus J.

doi:10.1359/jbmr.2000.15.12.2443

Cited by 101 publications

(96 citation statements)

References 49 publications

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“…The relatively small inter-day variation in 25OHD may be predominantly attributable to its longer biological half-life in blood, in addition to the gradual release of vitamin D from skin and fat cells; whereas variation in intact PTH was larger due to its shorter half-life. In contrast, the lack of a clear seasonal variation in 1α ,25(OH) 2 D is consistent with several previous studies [28][29][30][31] , but contradicts a few studies which did report seasonal variation 19,32) . In our subjects, seasonal variation may have been attenuated by inter-day variation in 1α ,25(OH) 2 D, as it is well known that 1α ,25(OH) 2 D synthesis is strictly regulated by PTH, calcium, and phosphorous.…”

Section: Discussionsupporting

confidence: 85%

Vitamin D Deficiency and Seasonal and Inter-day Variation in Circulating 25-hydroxyvitamin D and Parathyroid Hormone Levels in Indoor Daytime Workers: A Longitudinal Study

et al. 2011

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D (p=0.62). Notably, nearly all measured 25OHD levels in February were lower than the reference value of 20 ng/ml. Our study identified the occurrence of seasonal variation in circulating 25OHD and intact PTH levels, even after accounting for inter-day variability, and hypovitaminosis D in wintertime in indoor daytime male workers in Japan. Due to this variability, single spot measurements of 25OHD may lead to misjudgment of workers' vitamin D status.

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Section: Discussionsupporting

confidence: 85%

Vitamin D Deficiency and Seasonal and Inter-day Variation in Circulating 25-hydroxyvitamin D and Parathyroid Hormone Levels in Indoor Daytime Workers: A Longitudinal Study

et al. 2011

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“…Furthermore, 25-OHD represents the sum of vitamin D intake and dermal production [85]. Serum 25-OHD levels show a significant response to both sun exposure, as evidenced by the seasonal variation of levels, as well as to vitamin D supplementation [81,[86][87][88][89][90][91].…”

Section: -Hydroxy Vitamin D and 125-dihydroxy Vitamin Dmentioning

confidence: 99%

Assessment of vitamin D status – a changing landscape

Herrmann

Farrell²,

Pusceddu

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

194

184

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“…Table 7). With the exception of one small early study using a first generation assay [58], all studies identified reported a relative decrease in PTH concentration in summer and an increase in winter [54][55][56][57]. Studies undertaken with second generation assays suggested the difference between mean winter and summer concentrations was < 1 pmol/L [57,59].…”

Section: We Recommend Edta Plasma Samples For Pth Measurement Should mentioning

confidence: 99%

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

Hanon

Sturgeon

Lamb

2013

Clinical Chemistry and Laboratory Medicine (CCLM)

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Parathyroid hormone (PTH) is relatively unstable: optimisation of pre-analytical conditions, including specimen type, sampling time and storage conditions, is essential. We have undertaken a systematic review of these pre-analytical conditions. An electronic search of the PubMed, Embase, Cochrane, Centre for Research and Dissemination and Bandolier databases was undertaken. Of 5511 papers identified, 96 underwent full text review, of which 83 were finally included. At room temperature PTH was stable in ethylenediaminetetraacetic acid (EDTA) preserved whole blood for at least 24 h and in EDTA plasma for at least 48 h after venepuncture. Losses were observed in clotted blood samples after 3 h and in serum after 2 h. At 4°C PTH was more stable in EDTA plasma (at least 72 h) than serum (at least 24 h). Central venous PTH concentrations were higher than peripheral venous concentrations. In the northern hemisphere, PTH concentrations were higher in winter than summer. PTH has a circadian rhythm characterised by a nocturnal acrophase and mid-morning nadir. Data related to frozen storage of PTH (−20°C and −80°C) were limited and contradictory. We recommend that blood samples for PTH measurement should be taken into tubes containing EDTA, ideally between 10:00 and 16:00, and plasma separated within 24 h of venepuncture. Plasma samples should be stored at 4°C and analysed within 72 h of venepuncture. Particular regard must be paid to the venepuncture site when interpreting PTH concentration. Further research is required to clarify the suitability of freezing samples prior to PTH measurement.

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Circannual Rhythms and Interactions of Vitamin D Metabolites, Parathyroid Hormone, and Biochemical Markers of Skeletal Homeostasis: A Prospective Study

Abstract: ABSTRACT

Cited by 101 publications

References 49 publications

Vitamin D Deficiency and Seasonal and Inter-day Variation in Circulating 25-hydroxyvitamin D and Parathyroid Hormone Levels in Indoor Daytime Workers: A Longitudinal Study

Vitamin D Deficiency and Seasonal and Inter-day Variation in Circulating 25-hydroxyvitamin D and Parathyroid Hormone Levels in Indoor Daytime Workers: A Longitudinal Study

Assessment of vitamin D status – a changing landscape

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

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