Circannual versus seasonal variations of longitudinally sampled 25-hydroxycholecalciferol serum levels

Cugini, P; Coen, G; Scavo, D; Lucia, P; Mazzaferro, Sandro; Bianchini, G; Massimetti, Carlo; Donato, Giuseppe

doi:10.1016/0006-2944(84)90004-8

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Measurements of serum molecules and breast density were made at one single point in time in this cross-sectional study. The half-life of 25(OH)D in the blood is only 2-4 weeks [48, 49], thus variation in past exposure levels are not captured by a single measurement. The resulting misclassification may attenuate any association between vitamin D and breast density, and we cannot evaluate the temporality of the relation.…”

Section: Discussionmentioning

confidence: 99%

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The vitamin D pathway and mammographic breast density among postmenopausal women

Sprague

Trentham‐Dietz

Gangnon

et al. 2011

Breast Cancer Res Treat

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Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium. However, there is little epidemiologic data exploring the effects of vitamin D on breast cancer risk in the context of these other molecules. We examined a panel of molecules in the vitamin D pathway in relation to mammographic breast density, a marker of breast cancer risk, in the Wisconsin Breast Density Study. A total of 238 postmenopausal women (ages 55-70, with no history of postmenopausal hormone use) were enrolled from mammography clinics in Madison, Wisconsin. Subjects provided blood samples that were analyzed for levels of 25-hydroxy vitamin D [25(OH)D], PTH, insulin-like growth factor-1 (IGF1), IGF-binding protein 3 (IGFBP3), retinol, and calcium. Percent breast density was measured using Cumulus software. In age-adjusted analyses there was a positive association between 25(OH)D and percent breast density (P=0.05; mean percent density=11.3% vs. 15.6% for 1st vs. 4th quartile of 25(OH)D). Breast density was inversely associated with PTH (P=0.05; 16.0% vs. 11.4% for Q1 vs. Q4) and positively associated with the IGF-1:IGFBP-3 molar ratio (P=0.02; 11.9% vs. 15.6% for Q1 vs. Q4). However, these associations were all null after further adjustment for body mass index (BMI; P>0.25). The independent relation between 25(OH)D and breast density remained null among subgroups defined by BMI and serum levels of retinol, calcium, and estradiol. These results suggest no strong independent associations between the circulating molecules of the vitamin D pathway and mammographic breast density in postmenopausal women. While it remains possible that vitamin D could influence breast cancer risk, our results suggest that such an effect would be mediated through pathways other than breast density.

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Section: Discussionmentioning

confidence: 99%

“…In the general population, moderate correlation (r = 0.5) has been observed at up to 14 years between measurements [51]. Additionally, very little intra-individual diurnal variation in 25(OH)D levels has been observed [48, 52]. …”

Section: Discussionmentioning

confidence: 99%

The vitamin D pathway and mammographic breast density among postmenopausal women

Sprague

Trentham‐Dietz

Gangnon

et al. 2011

Breast Cancer Res Treat

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“…At the 45 th parallels there is a null period between November and February during which UV rays are insufficient to trigger vitamin D synthesis. Such fluctuations roughly correlate with seasonal variations in disease incidence and activity [113][114][115][116][117][118].…”

Section: Radiant Energy and Interstitial Watermentioning

confidence: 99%

Aether, Fields & Energy Dynamics in Living Bodies - Part II

Thorp¹,

Thorp²

2021

G Med Sci

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In this article, we examine dynamics of the three primary aether modalities in the water-body: first, the magnetic, which takes origin in the cardiovascular system; secondly, the radiant, related to ambient light-fall upon the body from the outside or that generated internally, and flows as organized currents in interstitial water; and the dielectric, which predominates in the intracellular fluid spaces, mediated by ion currents, and is involved in the generation and maintenance of cell structure and molecular energy metabolism.

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A Physiological view of in vivo calcium dynamics: The regulation of a nonlinear self-organized system

Staub

Tracqui

Lausson

et al. 1989

Bone

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Circannual versus seasonal variations of longitudinally sampled 25-hydroxycholecalciferol serum levels

Cited by 5 publications

References 13 publications

The vitamin D pathway and mammographic breast density among postmenopausal women

The vitamin D pathway and mammographic breast density among postmenopausal women

Aether, Fields & Energy Dynamics in Living Bodies - Part II

A Physiological view of in vivo calcium dynamics: The regulation of a nonlinear self-organized system

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