2020
DOI: 10.21203/rs.3.rs-130879/v1
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CircBCBM1 Promotes Breast Cancer Brain Metastasis via miR-125a/BRD4 Axis

Abstract: Background: Accumulating evidence indicates that circular RNAs (circRNAs) play critical roles in tumorigenesis and progression of various cancers. We previously identified a novel upregulated circRNA, circBCBM1 (hsa_circ_0001944), in the context of breast cancer brain metastasis. However, the potential biological function and molecular mechanism of circBCBM1 in breast cancer brain metastasis remain largely unknown.Methods: In this reserch, we validated the expression and characterization of circBCBM1 through R… Show more

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