circCDYL/microRNA-150-5p participates in modulating growth and migration of colon cancer cells

Cui, Wei; Dai, Jinyue; Ma, Jianbo

doi:10.4149/gpb_2019037

Cited by 33 publications

(23 citation statements)

References 34 publications

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“…For example, ectopic hsa_circ_0026782 (circITGA7) expression inhibits the growth and metastasis of CRC cells in vitro and in vivo, whereas the knockdown of circITGA7 promotes the proliferation and migration of CRC cells in vitro and increases CRC growth in vivo [89,90]. Moreover, hsa_circ_0008285 (circCDYL) decreases cell viability, impairs migration and invasion behaviors, and promotes cell apoptosis in CRC [91,92]; hsa_circ_ 0026344 overexpression decreases the growth and invasion of CRC cells while inducing cell apoptosis in vitro and inhibiting CRC growth in vivo [93,94]. In addition, some circRNAs inhibit the epithelial-mesenchymal transition (EMT), which is a process strongly correlated with metastasis, in CRC cells [73,94,95] (Fig.…”

Section: Oncogenic Functionsmentioning

confidence: 99%

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

et al. 2021

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Colorectal cancer (CRC) is a common hereditary tumor that is often fatal. Its pathogenesis involves multiple genes, including circular RNAs (circRNAs). Notably, circRNAs constitute a new class of noncoding RNAs (ncRNAs) with a covalently closed loop structure and have been characterized as stable, conserved molecules that are abundantly expressed in tissue/development-specific patterns in eukaryotes. Based on accumulating evidence, circRNAs are aberrantly expressed in CRC tissues, cells, exosomes, and blood from patients with CRC. Moreover, numerous circRNAs have been identified as either oncogenes or tumor suppressors that mediate tumorigenesis, metastasis and chemoradiation resistance in CRC. Although the regulatory mechanisms of circRNA biogenesis and functions remain fairly elusive, interesting results have been obtained in studies investigating CRC. In particular, the expression of circRNAs in CRC is comprehensively modulated by multiple factors, such as splicing factors, transcription factors, specific enzymes and cis-acting elements. More importantly, circRNAs exert pivotal effects on CRC through various mechanisms, including acting as miRNA sponges or decoys, interacting with RNA binding proteins, and even translating functional peptides. Finally, circRNAs may serve as promising diagnostic and prognostic biomarkers and potential therapeutic targets in the clinical practice of CRC. In this review, we discuss the dysregulation, functions and clinical significance of circRNAs in CRC and further discuss the molecular mechanisms by which circRNAs exert their functions and how their expression is regulated. Based on this review, we hope to reveal the functions of circRNAs in the initiation and progression of cancer and highlight the future perspectives on strategies targeting circRNAs in cancer research.

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Section: Oncogenic Functionsmentioning

confidence: 99%

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

et al. 2021

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“…It has been reported that circRNAs may mediate upregulation or downregulation of gene expression and, despite being classified as noncoding, may also encode proteins [13]. Moreover, circRNAs are stable and widely expressed in many tumor tissues [14,15]. Some circRNAs have important biological functions and can be considered as biomarkers for diagnosis of multiple diseases [4,16,17].…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0018818 knockdown suppresses tumorigenesis in non-small cell lung cancer by sponging miR-767-3p

Zhou

Gao

et al. 2020

Aging

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To identify potential therapeutic targets in non-small cell lung cancer NSCLC, we conducted a bioinformatics analysis of circRNAs differentially expressed between NSCLC tissues and adjacent normal tissues. Cell proliferation and apoptosis was assessed using CCK-8 and flow cytometry, respectively. A connection between hsa_circ_0018818 and miR-767-3p was confirmed in dual luciferase reporter assays. Gene and protein expression in NSCLC cells were measured using quantitative PCR and Western-blotting, respectively. And a xenograft tumor model was established to assess the function of hsa_circ_0018818 in NSCLC in vivo. Hsa_circ_0018818 was greatly upregulated in NSCLC tumor tissues. Knocking down hsa_circ_0018818 using a targeted shRNA inhibited the proliferation and invasiveness of NSCLC cells and induced their apoptosis via the miR-767-3p/Nidogen 1 (NID1) signaling axis. Hsa_circ_0018818 knockdown also inactivated Epithelialmesenchymal transition (EMT) process and PI3K/Akt signaling. In summary, hsa_circ_0018818 knockdown inhibited NSCLC tumorigenesis in vitro and in vivo, which suggests it could potentially serve as a target for the treatment of NSCLC.

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“…Through their miRNA-sponging action ( Figure 3 A), several circRNAs regulate the proliferation and migration of CRC cells and affect therapy resistance. For instance, circ-CDYL has been shown to bind to miR-150-5p, the upregulation of which has been associated with the downregulation of PTEN and phosphorylation of PI3K, AKT, JAK2, and STAT5, which are key players in CRC signaling [ 32 ].…”

Section: Functions In Crcmentioning

confidence: 99%

Circular RNAs: A New Piece in the Colorectal Cancer Puzzle

Artemaki

Scorilas

Kontos

2020

Cancers

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Colorectal cancer (CRC) is the third most fatal type of malignancy, worldwide. Despite the advances accomplished in the elucidation of its molecular base and the existing CRC biomarkers introduced in the clinical practice, additional research is required. Circular RNAs (circRNAs) constitute a new RNA type, formed by back-splicing of primary transcripts. They have been discovered during the 1970s but were characterized as by-products of aberrant splicing. However, the modern high-throughput approaches uncovered their widespread expression; therefore, several questions were raised regarding their potential biological roles. During the last years, great progress has been achieved in the elucidation of their functions: circRNAs can act as microRNA sponges, transcription regulators, and interfere with splicing, as well. Furthermore, they are heavily involved in various human pathological states, including cancer, and could serve as diagnostic and prognostic biomarkers in several diseases. Particularly in CRC, aberrant expression of circRNAs has been observed. More specifically, these molecules either inhibit or promote colorectal carcinogenesis by regulating different molecules and signaling pathways. The present review discusses the characteristics and functions of circRNA, prior to analyzing the multifaceted role of these molecules in CRC and their potential value as biomarkers and therapeutic targets.

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circCDYL/microRNA-150-5p participates in modulating growth and migration of colon cancer cells

Cited by 33 publications

References 34 publications

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

Hsa_circ_0018818 knockdown suppresses tumorigenesis in non-small cell lung cancer by sponging miR-767-3p

Circular RNAs: A New Piece in the Colorectal Cancer Puzzle

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