2021
DOI: 10.21203/rs.3.rs-288523/v1
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circDym prevents chronic neuropathic pain by competitive inhibition of Nlgn2 mRNA transport in neurites

Abstract: Aims: Neuropathic pain (NP) is a chronic syndrome that is refractory to current analgesics through unknown mechanisms. Epigenetic regulation in spinal dorsal horn neurons is reported to contribute to the initiation and maintenance of NP. Circular RNAs (circRNAs) are involved in various biological processes in neurons, but molecular mechanism of how the involvement in NP are lacking. Methods: To study NP, we used a sciatic chronic constriction injury (CCI) model in C57 mice, with the level of mechanical allodyn… Show more

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