CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis

Zhang, Yue; Tan, Dandan; Xie, Yi; Wu, Linyu; Wu, Song; Tang, Yuhui; Luo, Yongzhou; Xiao, Xia; Li, Xing

doi:10.1155/2022/1028851

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…27 Although identified only recently, circEPSTI1 has been noted to support tumorigenesis and progression in cervical cancer, 13 oral squamous cell carcinoma, 14 ovarian cancer, 15 non-small cell lung cancer, 16 and breast cancer. 17 The functions and diagnostic performance of circEPSTI1 in EC, however, have not been previously documented.…”

Section: Discussionmentioning

confidence: 99%

“…11,12 Of note, circEPSTI1 can reportedly enhance certain oncogenic activities in cervical cancer, 13 oral squamous cell carcinoma, 14 ovarian cancer, 15 non-small cell lung cancer, 16 and breast cancer. 17 How circEPSTI1 functions in EC, however, remains poorly understood. One recent study also determined that macrophage migration inhibitory factor (MIF) levels are closely associated with EC patient prognostic outcomes.…”

Section: Introductionmentioning

confidence: 99%

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The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer

Cui,

Zhou,

et al. 2024

IJGM

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Background: Circular RNAs (circRNAs) exhibit unique patterns of expression and high levels of stability in patient plasma samples such that they represent ideal non-invasive biomarkers that can be leveraged to detect a wide array of diseases including endometrial cancer (EC). This study was designed to identify circRNAs with potential diagnostic utility in serum samples from EC patients while also evaluating the utility of macrophage migration inhibitory factor (MIF) as a biomarker when screening for this form of cancer in the clinic. Methods: Levels of circEPSTI1 and MIF were assessed in the plasma of EC patients and healthy subjects (n=186 each) through qPCR and ELISAs. The diagnostic utility of these biomarkers was assessed with receiver operating characteristic curve (ROC) analyses. Results: Relative to healthy subjects, EC patient serum contained significantly elevated circEPSTI1 and MIF. An association was noted between circEPSTI1 expression in stages, histologic grade, and residual tumor. ROC curves confirmed that serum circEPSTI1 levels distinguished between controls and patients with EC with an Area of 0.835 and serum MIF levels distinguished between controls and patients with EC with an Area of 0.6646. When instead diagnosing patients based on the combination of MIF and circEPSTI1, the Area further rose to 0.8604. Conclusion: Assessing the combination of circEPSTI1 and MIF may be a viable approach to reliably diagnosing EC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer

Cui,

Zhou,

et al. 2024

IJGM

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“…Moreover, ERBB3, as a member of the ErbB family, has been extensively studied for its therapeutic mechanism and efficacy in targeting Her2-positive breast cancer. This study adds to the understanding of the development of Her2-positive breast cancer and offers a potential marker and therapeutic approach ( 38 ).…”

Section: Molecular Mechanism Of Circrna In Breast Cancermentioning

confidence: 97%

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Li,

Zhang,

et al. 2024

Transl Cancer Res

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Background and Objective Breast cancer is presently the most prevalent cancer and the leading cause of cancer-related deaths in women worldwide. Circular RNA (circRNA) is a class of closed circRNAs lacking a 5'-end cap structure and a 3'-end polyA tail, which is highly stable and widely involved in a variety of pathophysiological processes such as cell proliferation, differentiation, and apoptosis. In recent years, accumulating studies have shown that circRNAs play an important role in the development and prognosis of breast cancer, but there are fewer literature reviews on their intrinsic molecular mechanisms which is the aim of this study. Methods This review synthesizes the findings of literature retrieved from searches of PubMed and Google Scholar databases, hand searches, and authoritative texts. Citations mainly originate from the past 3 years. The articles need to describe the role of circRNA in breast cancer; no language restrictions were imposed. Key Content and Findings This review summarizes the latest relevant literature and systematically reviews the four main mechanisms of circRNA in breast cancer from the perspective of circRNA function. At the same time, we describe the formation mechanism, characterization, and biological functions of circRNAs. Conclusions We reviewed the status of actual knowledge about circRNA biogenesis and functions and summarized novel findings regarding the molecular mechanism of circRNA in breast cancer. Meanwhile, this review explores the possibility of circRNAs for becoming new biodiagnostic indicators and therapeutic targets in breast cancer.

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“…In addition, miR-145-5p has previously been linked to BCa biology. MiR-145-5p behaves as a tumor suppressor in BCa and has been shown to reduce cell motility and invasion in in vitro assays [20,33,34]. Figure 4A highlights one of the predicted binding sites (with the highest binding score) of miR-145-5p with circSTAG2 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Circstag2 May Act As a Sponge For Mir-145-5p In Bca Cellsmentioning

confidence: 99%

Circular STAG2 RNA Modulates Bladder Cancer Progression via miR-145-5p/TAGLN2 and Is Considered as a Biomarker for Recurrence

Du,

Waltzer,

Wilusz

et al. 2024

Cancers

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The current study aimed to elucidate the regulatory mechanisms of the circRNA hsa_circ_0139697 (circSTAG2(16–25)) in BCa and to consider the opportunity of using circSTAG2(16–25) isolated from BCa patient urine as a marker for disease development prediction. The selection of this circRNA was determined by the special role of its parental gene STAG2 in BCa biology. The circRNA hsa_circ_0139697 was chosen from 25 STAG2 circRNAs due to its differential expression in the urine of BCa patients and healthy volunteers. Higher levels of circSTAG2(16–25) were detected in urine samples obtained from patients with recurrent tumors. A higher expression of circSTAG2(16–25) was also detected in more tumorigenic BCa cell lines. The overexpression of circSTAG2(16–25) in BCa cells induced the elevation of proliferation, motility, and invasion. To study the mechanisms of circSTAG2(16–25) activity, we confirmed that circSTAG2(16–25) can bind miR-145-5p in vitro as was predicted by bioinformatic search. miR-145-5p was shown to suppress some genes that promoted BCa progression. One of these genes, TAGLN2, encodes the protein Transgelin 2, which plays a role in BCa cell motility and invasion. Therefore, the possible mechanism of action of circSTAG2(16–25) could be sponging the tumor suppressor miR-145-5p, which results in activation of TAGLN2. In addition, circSTAG2(16–25) might be considered as a potential biomarker for recurrence prediction.

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CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis

Cited by 5 publications

References 40 publications

The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer

The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Circular STAG2 RNA Modulates Bladder Cancer Progression via miR-145-5p/TAGLN2 and Is Considered as a Biomarker for Recurrence

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