Abstract:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Circular RNAs (circRNAs) play critical roles in the progression of HCC. However, the role of the newly identified circFGGY (hsa_circ_0006633) in the development and progression of HCC has not been explored. In this study, we found that circFGGY was significantly downregulated in tumor compared with that in adjacent normal liver tissues of patients with HCC. HCC patients with low circFGGY expression had poor overall s… Show more
“…By regulating the miR-548c-3p/laminin subunit gamma 2 (LAMC2) axis, circ-0101145 acts as an oncogene to promote EMT in HCC ( 63 ). CircSEC24A (hsa_circ_0003528) and circFGGY also function as crucial regulators in EMT of HCC by competitively targeting miRNA, regulating target protein expression ( 64 , 65 ).…”
Section: Novel Function Of Circrna In Hccmentioning
Hepatocellular carcinoma (HCC) is one of the most frequent malignancies, with high incidence and mortality. As the majority of HCC patients are diagnosed at an advanced stage and die of recurrence and metastasis, its pathology and new biomarkers are needed. Circular RNAs (circRNAs) are a large subclass of long non-coding RNAs (lncRNAs) with covalently closed loop structures and abundant, conserved, stable, tissue-specific expression in mammalian cells. CircRNAs exert multiple functions in HCC initiation, growth and progression, serving as promising biomarkers for diagnosis, prognosis and therapeutic targets for this disease. This review briefly describes the biogenesis and biological functions of circRNAs and elucidates the roles of circRNAs in the development and progression of HCC, especially regarding epithelial-mesenchymal transition (EMT), drug resistance and interactions with epigenetic modifications. In addition, this review highlights the implications of circRNAs as potential biomarkers and therapeutic targets for HCC. We hope to provide novel insight into the roles of circRNAs in HCC.
“…By regulating the miR-548c-3p/laminin subunit gamma 2 (LAMC2) axis, circ-0101145 acts as an oncogene to promote EMT in HCC ( 63 ). CircSEC24A (hsa_circ_0003528) and circFGGY also function as crucial regulators in EMT of HCC by competitively targeting miRNA, regulating target protein expression ( 64 , 65 ).…”
Section: Novel Function Of Circrna In Hccmentioning
Hepatocellular carcinoma (HCC) is one of the most frequent malignancies, with high incidence and mortality. As the majority of HCC patients are diagnosed at an advanced stage and die of recurrence and metastasis, its pathology and new biomarkers are needed. Circular RNAs (circRNAs) are a large subclass of long non-coding RNAs (lncRNAs) with covalently closed loop structures and abundant, conserved, stable, tissue-specific expression in mammalian cells. CircRNAs exert multiple functions in HCC initiation, growth and progression, serving as promising biomarkers for diagnosis, prognosis and therapeutic targets for this disease. This review briefly describes the biogenesis and biological functions of circRNAs and elucidates the roles of circRNAs in the development and progression of HCC, especially regarding epithelial-mesenchymal transition (EMT), drug resistance and interactions with epigenetic modifications. In addition, this review highlights the implications of circRNAs as potential biomarkers and therapeutic targets for HCC. We hope to provide novel insight into the roles of circRNAs in HCC.
“…Additionally, circFGGY suppresses HCC invasion, proliferation, and epithelial-mesenchymal transition by upregulating the expression of Smad7, a gatekeeper of the TGF-β signalling pathway as shown in Fig. 4 [ 135 ]. Fig.…”
Section: Functional Implications Of Lncrna Through Hedgehog Signaling...mentioning
“…Nineteen circRNA/miR-545-3p axes promote cancer progression, including Circ_PRKCI/miR-545-3p/E2F7 in glioblastoma (GBM)/low-grade glioma (LGG) 24 ; Circ_0072083/miR-545-3p/CBLL1 in lung cancer (LC) 7 ; Circ_0007580/miR-545-3p/PRKCA, 15 Circ_FOXO3/miR-545-3p/HMGB3, 25 Circ_0014130/miR-545-3p/YAP1, 26 Circ_PRKCI/miR-545-3p/E2F7, 27 and Circ_PRKCI/miR-545-3p in gastric cancer (GC) 8 ; Circ_FGGY/miR-545-3p/SMAD7 in HCC 28 ; Circ_0026416/miR-545-3p/MYO6 in CRC 16 ; Circ_SAMD4A/miR-545-3p/PFKFB3 29 and Circ_0003732/miR-545-3p/CCNA2 in osteosarcoma (SaOS) 30 ; Circ_0072008/miR-545-3p/SLC7A11 in pancreatic ductal adenocarcinoma (PDAC) 60 ; Circ_IFT80 (Circ_0067835)/miR-545-3p/FAM98A in endometrial cancer (EC) 31 ; Circ_0067934/miR-545-3p/PPA1 in ovarian cancer (OC) 32 ; Circ_PRKCI/miR-545-3p/WBP2 33 and Circ_0067934/miR-545-3p/EIF3C in cervical carcinoma (CxCa) 34 ; Circ_ZFR/miR-545-3p/WMT5A in bladder cancer; and Circ_0067934/miR-545-3p/SLC7A11 axis in THCA. 35 Additionally, the Circ_UBR1/miR-545-5p/SSFA2 axis promoted the malignant behavior of cancer cells in LC.…”
Section: Mir-545 and Its Competing Endogenous Ribonucleic Acids (Cernas)mentioning
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
