circLRP6 regulates high glucose‐induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells

Bin, Chen; Li, Yanhua; Liu, Yang; Xu, Zhenhe

doi:10.1002/jcp.28730

Cited by 106 publications

(99 citation statements)

References 35 publications

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“…But, a handful of researches uncovered that circRNAs participated in regulating inflammatory response and affected the progression of inflammation‐associated ailments. One research attested that circLRP6 mediated high glucose (HG)‐engendered mesangial cells oxidative stress and inflammation . Moreover, Zhao et al discovered that hsa_circ_0018429, hsa_circ_0026579, hsa_circ_0099188, and hsa_circ_0012535 were both increased in the blood from community‐acquired pneumonia (CAP) patients, which might be the crucial diagnostic biomarkers for CAP .…”

Section: Introductionmentioning

confidence: 99%

Retracted: Protective impacts of circular RNA VMA21 on lipopolysaccharide‐engendered WI‐38 cells injury via mediating microRNA‐142‐3p

Yang¹,

Gao²,

Zhou³

et al. 2019

BioFactors

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CircRNA derived from vacuolar ATPase assembly factor (circVMA21) is a newly‐researched circRNA, which is reported to adjust the degeneration of intervertebral disc. But, function of circVMA21 in infantile pneumonia is yet to be explored. The research surveyed the role of circVMA21 in lipopolysaccharide (LPS)‐caused WI‐38 cell inflammatory injury. LPS (10 μg/ml, 12 hr) was exploited to arouse WI‐38 cell inflammatory injury. Subsequently, the mediatory impacts of microRNA (miR)‐142‐3p and circVMA21 in LPS‐evoked cell injury were detected after transfection with the inhibited or overexpressed vectors. In above processes, cell behaviors of cell viability, apoptosis, and pro‐inflammatory factors were monitored. NF‐κB and JNK pathways were elucidated to showcase the feasible molecular mechanisms. Results displayed that LPS engendered WI‐38 cell inflammatory injury was alleviated as well as activated NF‐κB and JNK pathways was interdicted by miR‐142‐3p suppression. Importantly, restrained miR‐142‐3p expression was discovered in WI‐38 cells after overexpressing circVMA21. Moreover, overexpressed circVMA21 exerted the similar functions as miR‐142‐3p suppression in LPS‐triggered WI‐38 cell injury. But, the influence was clearly reversed by miR‐142‐3p overexpression. Hindered NF‐κB and JNK pathways caused by overexpressed circVMA21 was also crippled by miR‐142‐3p overexpression. The research discolsed that circVMA21 protected WI‐38 cells to resist LPS‐triggered inflammatory injury via miR‐142‐3p‐NF‐κB/JNK axis.

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Section: Introductionmentioning

confidence: 99%

Retracted: Protective impacts of circular RNA VMA21 on lipopolysaccharide‐engendered WI‐38 cells injury via mediating microRNA‐142‐3p

Yang¹,

Gao²,

Zhou³

et al. 2019

BioFactors

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“…For instance, circRNA LRP6 contributes to high-glucose-induced inflammation and extracellular matrix accumulation in mesangial cells by sponging miR-205. 10) circPTN regulates proliferation activity in glioma by targeting miR-145-5p/miR-330-5p. 30) Accumulating evidence points to the potential role of miRNAs in DKD progression.…”

Section: Discussionmentioning

confidence: 99%

“…4,7,8) Our previous study indicated that pyroptosis is involved in tubular injury in diabetes, as evidenced by GSDMD p30 fragment generation and flow cytometry analysis. 9) Understanding the molecular cascades regulating pyroptosis will yield additional targets for DKD treatment.…”

Section: Introductionmentioning

confidence: 99%

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circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells <i>via</i> Pyroptosis

et al. 2020

Biological & Pharmaceutical Bulletin

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Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. Current therapies for DKD are insufficient. Therefore, there is an urgent need for identifying new therapies. An increasing number of micro RNAs (miRNAs) and long noncoding RNAs (lncRNAs) have been demonstrated to modulate the progression of diabetic kidney disease. Nevertheless, until now, there have been few reports evaluating the relevance of circular RNAs (circRNAs) in DKD. circRNAs have been reported to regulate the occurrence and development of multiple diseases. In this study, we intended to explore the circRNA expression profiles and determine the role of circRNA in DKD. We identified a series of dysregulated circRNAs in glucose-stressed HK-2 cells using circRNA microarray analysis. Among the candidate circRNAs, we found that circACTR2 was upregulated and may be involved in inflammation and pyroptosis. Knockdown of circACTR2 significantly decreased pyroptosis, interleukin (IL)-1β release and collagen IV and fibronectin production, indicating the effective regulation by circACTR2 of cell death and inflammation. Overall, our study identified a new circRNA, circACTR2, that regulates high glucose-induced pyroptosis, inflammation and fibrosis in proximal tubular cells. The present study preliminarily explores the role of circRNAs in pyroptosis of tubular cells, and provides novel insight into the pathogenesis of DKD and new therapeutic strategies.

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“…diabetic nephropathy (dn) is becoming the most pervasive complication for both types i and ii diabetes, and is also the major cause of end-stage renal disease in the majority of developed and developing countries (1). clinically, dn is characterized by mesangial hypertrophy, mesangial cell (Mc) proliferation, albuminuria, extracellular matrix (ecM) accumulation and kidney fibrosis (2,3).…”

Section: Introductionmentioning

confidence: 99%

A novel identified circular RNA, circ_0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR‑101b by targeting TGFβRI

Mou¹,

Chenv²,

Zhou³

et al. 2020

Mol Med Rep

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circular rnas (circrnas) have crucial roles in various diseases; however, the mechanisms of action underlying circrnas in the occurrence and development of diabetic nephropathy (dn) remains largely unknown. The present study investigated the differentially expressed circrnas in the dn mice kidney cortex using circrna sequencing and elucidated the role of circrnas in mesangial cells. it was revealed that 40 circrnas were unconventionally expressed, including 18 upregulated circrnas and 22 downregulated circRNAs. Furthermore, circ_0000491 levels were significantly augmented in both dn mice and high glucose (HG, 30 mM)-induced mouse mesangial cells (MeS13 cells). Knockdown of circ_0000491 significantly suppressed the increase of vimentin, fibronectin and α-smooth muscle actin, as well as collagen type i, iii and iV, whilst reversing the decrease of e-cadherin in HG-induced MeS13 cells. it was further revealed that circrna_0000491 sponged mir-101b and that mir-101b directly targets TGFβri. in addition, the expression levels of mir-101b were negatively associated with the transcriptional level of circrna_0000491 and mir-101b inhibitors reversed the suppression of extracellular matrix (ecM)-associated protein synthesis mediated by knocking-down circrna_0000491. in conclusion, the present study investigated the circrna_0000491/mir-101b/TGFβri axis in ecM accumulation and fibrosis-associated protein expression levels of mesangial cells, which suggested that circRNA_0000491 may be beneficial for the development of an effective therapeutic target for dn.

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circLRP6 regulates high glucose‐induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells

Cited by 106 publications

References 35 publications

Retracted: Protective impacts of circular RNA VMA21 on lipopolysaccharide‐engendered WI‐38 cells injury via mediating microRNA‐142‐3p

Retracted: Protective impacts of circular RNA VMA21 on lipopolysaccharide‐engendered WI‐38 cells injury via mediating microRNA‐142‐3p

circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells <i>via</i> Pyroptosis

A novel identified circular RNA, circ_0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR‑101b by targeting TGFβRI

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