circPIP5K1A serves as a competitive endogenous RNA contributing to ovarian cancer progression via regulation of miR‐661/IGFBP5 signaling

Sun, Yi; Li, Xue; Chen, Aozheng; Shi, Weihui; Wang, Lei; Yi, Ru-hai; Qiu, Jin

doi:10.1002/jcb.29055

Cited by 41 publications

(33 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies support that IGFBPs can exert either an oncogenic or an onco-suppressive role, via the regulation of the IGFR/MAPK and IGFR/PI3K/AKT signaling pathways [ 77 ]. It has been observed that circRNAs increase the levels of specific oncogenic IGFBPs, and, subsequently, promote cancer progression [ 78 , 79 ]. However, whether cancer progression is mediated through IGFR/MAPK and/or IGFR/PI3K/AKT signaling activation remains to be revealed.…”

Section: Circrna-mediated Regulation Of Major Signaling Pathwaysmentioning

confidence: 99%

Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression

Papatsirou

Artemaki

Karousi

et al. 2021

Cancers

View full text Add to dashboard Cite

Signal transduction is an essential process that regulates and coordinates fundamental cellular processes, such as development, immunity, energy metabolism, and apoptosis. Through signaling, cells are capable of perceiving their environment and adjusting to changes, and most signaling cascades ultimately lead to alterations in gene expression. Circular RNAs (circRNAs) constitute an emerging type of endogenous transcripts with regulatory roles and unique properties. They are stable and expressed in a tissue-, cell-, and developmental stage-specific manner, while they are involved in the pathogenesis of several diseases, including cancer. Aberrantly expressed circRNAs can mediate cancer progression through regulation of the activity of major signaling cascades, such as the VEGF, WNT/β-catenin, MAPK, PI3K/AKT, and Notch signaling pathways, as well as by interfering with signaling crosstalk. Deregulated signaling can then function to induce angiogenesis, promote invasion, migration, and metastasis, and, generally, modulate the hallmarks of cancer. In this review article, we summarize the most recently described and intriguing cases of circRNA-mediated signaling regulation that are involved in cancer progression, and discuss the biomarker potential of circRNAs, as well as future therapeutic applications.

show abstract

Section: Circrna-mediated Regulation Of Major Signaling Pathwaysmentioning

confidence: 99%

Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression

Papatsirou

Artemaki

Karousi

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…Recent data have proved that several circRNAs can influence the growth, survival, invasion, EMT, angiogenesis, and drug resistance in gynecological cancers. Manipulation of circRNA abundance has been shown to possess anti-tumor activities in experimental xenograft models of CC [88,91,95], OC [121,123,124] and EC [156].…”

Section: Circrnas As Potential Therapeutic Targets For Gynecological mentioning

confidence: 99%

“…Several circRNAs (such as circEPSTI1, circGFRA1, circ0051240, circPIP5K1A, circPVT1 and circABCB10) have been found to increase the proliferative and invasive capacities of OC cells by acting as miRNA sponges [ 121 , 122 , 123 , 124 , 125 , 126 ]. Knockdown of circSMAD7 by short-hairpin RNA (shRNA) was associated with decreased cell proliferation, migration and invasion and with increased expression of KLF6 in CC cells [ 127 ].…”

Section: The Expression Functions and Mechanisms Of Circrnas In Gmentioning

confidence: 99%

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Dong

Xiong

et al. 2020

Cancers

View full text Add to dashboard Cite

Circular RNAs (circRNAs) are covalently closed, endogenous non-coding RNAs and certain circRNAs are linked to human tumors. Owing to their circular form, circRNAs are protected from degradation by exonucleases, and therefore, they are more stable than linear RNAs. Many circRNAs have been shown to sponge microRNAs, interact with RNA-binding proteins, regulate gene transcription, and be translated into proteins. Mounting evidence suggests that circRNAs are dysregulated in cancer tissues and can mediate various signaling pathways, thus affecting tumorigenesis, metastasis, and remodeling of the tumor microenvironment. First, we review the characteristics, biogenesis, and biological functions of circRNAs, and describe various mechanistic models of circRNAs. Then, we provide a systematic overview of the functional roles of circRNAs in gynecological cancers. Finally, we describe the potential future applications of circRNAs as biomarkers for prognostic stratification and as therapeutic targets in gynecological cancers. Although the function of most circRNAs remains elusive, some individual circRNAs have biologically relevant functions in cervical cancer, ovarian cancer, and endometrial cancer. Certain circRNAs have the potential to serve as biomarkers and therapeutic targets in gynecological cancers.

show abstract

“…CircRNAs, a new class of ncRNAs with the special ring structure, are stably expressed in multiple cells and once considered as transcriptional splicing intermediates, byproducts or accidental splicing errors. Accumulating evidences indicated that circRNAs play a key regulatory role in cell physiological process and human diseases, including cancer via sponging miRNAs or interacting with various proteins [190][191][192]. In addition, the annular structure endows circRNAs with inherent stability, which enables them to accumulate in exosomes and exist stably in peripheral body fluids such as plasma and saliva.…”

Section: Circrnas and Chemoresistance In Gastric Cancermentioning

confidence: 99%

Noncoding RNAs in gastric cancer: implications for drug resistance

et al. 2020

View full text Add to dashboard Cite

Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths worldwide. Advanced gastric cancer patients can notably benefit from chemotherapy including adriamycin, platinum drugs, 5-fluorouracil, vincristine, and paclitaxel as well as targeted therapy drugs. Nevertheless, primary drug resistance or acquisition drug resistance eventually lead to treatment failure and poor outcomes of the gastric cancer patients. The detailed mechanisms involved in gastric cancer drug resistance have been revealed. Interestingly, different noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), are critically involved in gastric cancer development. Multiple lines of evidences demonstrated that ncRNAs play a vital role in gastric cancer resistance to chemotherapy reagents and targeted therapy drugs. In this review, we systematically summarized the emerging role and detailed molecular mechanisms of ncRNAs impact drug resistance of gastric cancer. Additionally, we propose the potential clinical implications of ncRNAs as novel therapeutic targets and prognostic biomarkers for gastric cancer.

show abstract

circPIP5K1A serves as a competitive endogenous RNA contributing to ovarian cancer progression via regulation of miR‐661/IGFBP5 signaling

Cited by 41 publications

References 32 publications

Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression

Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Noncoding RNAs in gastric cancer: implications for drug resistance

Contact Info

Product

Resources

About