CircPVT1 promotes progression in clear cell renal cell carcinoma by sponging miR‐145‐5p and regulating TBX15 expression

Zheng, Zijie; Chen, Zhiliang; Zhong, Qiyu; Zhu, Dingjun; Xie, Yingwei; Shangguan, Wentai; Xie, Wenlian

doi:10.1111/cas.14814

Cited by 30 publications

(30 citation statements)

References 31 publications

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“…They found that circPVT1 expression was significantly increased in patients’ serum. Moreover, they found that circPVT1 explicates its tumorigenic activity by directly interacting with miR-145-5p leading to the upregulation of one of its targets TBX15 (T-Box Transcription Factor 15), associated with the progression of RCC [ 71 ]. Intriguingly, other recent study by Zheng X. and colleagues revealed that circPVT1 is associated with medullary thyroid cancer, sustaining the metastatic process by acting on miR-455-5p/CXCL12/CXCR4 signaling axis [ 71 ].…”

Section: The Circpvt1/lncpvt1/c-myc Oncogenic Networkmentioning

confidence: 99%

“…Moreover, they found that circPVT1 explicates its tumorigenic activity by directly interacting with miR-145-5p leading to the upregulation of one of its targets TBX15 (T-Box Transcription Factor 15), associated with the progression of RCC [ 71 ]. Intriguingly, other recent study by Zheng X. and colleagues revealed that circPVT1 is associated with medullary thyroid cancer, sustaining the metastatic process by acting on miR-455-5p/CXCL12/CXCR4 signaling axis [ 71 ]. CircPVT1 results to be involved also in gall bladder cancer (GBC) where Wang S. and colleagues demonstrated that it is upregulated and promotes proliferation, migration and invasion as well as inhibits cell apoptosis acting as a miRNA sponge for miR-339-3p thus upregulation its target MCL-1 (myeloid cell leukemia-1) which is an anti-apoptotic protein involved in cancer progression [ 73 ].…”

Section: The Circpvt1/lncpvt1/c-myc Oncogenic Networkmentioning

confidence: 99%

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CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals

Palcau¹,

Canu²,

Donzelli³

et al. 2022

Mol Cancer

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The role of circular RNAs in oncogenesis has begun to be widely studied in recent years, due to the significant impact that these molecules have in disease pathogenesis, as well as their potential for the future of innovative therapies. Moreover, due to their characteristically circular shape, circular RNAs are very resistant molecules to RNA degradation whose levels are easily assessed in body fluids. Accordingly, they represent an opportunity for the discovery of new diagnostic and prognostic markers in a wide range of diseases. Among circular RNAs, circPVT1 is a rather peculiar one that originates from the circularization of the exon 2 of the PVT1 gene that encodes a pro-tumorigenic long non-coding RNA named lncPVT1. There are a few examples of circular RNAs that derive from a locus producing another non-coding RNA. Despite their apparent transcriptional independence, which occurs using two different promoters, a possible synergistic effect in tumorigenesis cannot be excluded considering that both have been reported to correlate with the oncogenic phenotype. This complex mechanism of regulation appears to also be controlled by c-MYC. Indeed, the PVT1 locus is located only 53 Kb downstream c-MYC gene, a well-known oncogene that regulates the expression levels of about 15% of all genes. Here, we review circPVT1 origin and biogenesis highlighting the most important mechanisms through which it plays a fundamental role in oncogenesis, such as the well-known sponge activity on microRNAs, as well as its paradigmatic interactome link with lncPVT1 and c-MYC expression.

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Section: The Circpvt1/lncpvt1/c-myc Oncogenic Networkmentioning

confidence: 99%

Section: The Circpvt1/lncpvt1/c-myc Oncogenic Networkmentioning

confidence: 99%

CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals

Palcau¹,

Canu²,

Donzelli³

et al. 2022

Mol Cancer

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“…For instance, the miR-19b-3p released in ccRCC by exosomes in the microenvironment is responsible for both activating EMT via r PTEN and cross talking with long distant niches to favor metastasis [145]. The circular RNA, named circPVT1, is upregulated in ccRCC tissue according to the histopathology [146]. CircPVT1 directly binds the miR-145-5p.…”

Section: Deregulation Of Mirnas In Ccrcc Tissuementioning

confidence: 99%

Circulating microRNAs from the Molecular Mechanisms to Clinical Biomarkers: A Focus on the Clear Cell Renal Cell Carcinoma

Tito

Falco

Rosa

et al. 2021

Genes

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microRNAs (miRNAs) are emerging as relevant molecules in cancer development and progression. MiRNAs add a post-transcriptional level of control to the regulation of gene expression. The deregulation of miRNA expression results in changing the molecular circuitry in which miRNAs are involved, leading to alterations of cell fate determination. In this review, we describe the miRNAs that are emerging as innovative molecular biomarkers from liquid biopsies, not only for diagnosis, but also for post-surgery management in cancer. We focus our attention on renal cell carcinoma, in particular highlighting the crucial role of circulating miRNAs in clear cell renal cell carcinoma (ccRCC) management. In addition, the functional deregulation of miRNA expression in ccRCC is also discussed, to underline the contribution of miRNAs to ccRCC development and progression, which may be relevant for the identification and design of innovative clinical strategies against this tumor.

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“…Finally, miR-199a-5p and miR‐145‐5p have been identified as targets of circPVT1 in glioblastoma ( 39 ) and clear cell renal cell carcinoma ( 40 ), respectively.…”

Section: In Vitro Studiesmentioning

confidence: 99%

A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

et al. 2021

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CircPVT1 (hsa_circ_0001821) is a cancer-related circular RNA (circRNA) that originated from a genomic locus on chromosome 8q24. This locus has been previously found to encode the oncogenic long non-coding RNA PVT1. Expression of this circRNA has been found to be upregulated in diverse neoplastic conditions. CircPVT1 acts as a sponge for miR-125a, miR-125b, miR-124-3p, miR-30a-5p, miR-205-5p, miR‐423‐5p, miR‐526b, miR-137, miR-145-5p, miR-497, miR-30d/e, miR-455-5p, miR-29a-3p, miR-204-5p, miR-149, miR-106a-5p, miR-377, miR-3666, miR-203, and miR-199a-5p. Moreover, it can regulate the activities of PI3K/AKT, Wnt5a/Ror2, E2F2, and HIF-1α. Upregulation of circPVT1 has been correlated with decreased survival of patients with different cancer types. In the current review, we explain the oncogenic impact of circPVT1 in different tissues based on evidence from in vitro, in vivo, and clinical investigations.

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CircPVT1 promotes progression in clear cell renal cell carcinoma by sponging miR‐145‐5p and regulating TBX15 expression

Cited by 30 publications

References 31 publications

CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals

CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals

Circulating microRNAs from the Molecular Mechanisms to Clinical Biomarkers: A Focus on the Clear Cell Renal Cell Carcinoma

A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

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