2018
DOI: 10.1002/jcp.27122
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CircRBMS3 promotes gastric cancer tumorigenesis by regulating miR‐153–SNAI1 axis

Abstract: Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. Mounting evidence showed that circular RNAs (circRNAs) play critical roles in human malignancy. However, the knowledge about circRNAs in GC is still unclear. In the current study, high throughput microarray assay showed that circRBMS3 was upregulated in GC tissues, which was further confirmed by quantitative reverse transcription polymerase chain reaction. Correlation analysis revealed that high circRBMS3 expression was associa… Show more

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Cited by 22 publications
(20 citation statements)
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“…For example, circIRAK3 functions as a sponge of miR-3607 to facilitate breast cancer metastasis [28]. CircRBMS3 promotes gastric cancer progression by regulating miR-153 [29]. In this study, we found that circMTO1 could directly bind to miR-182-5p.…”
Section: Discussionmentioning
confidence: 56%
“…For example, circIRAK3 functions as a sponge of miR-3607 to facilitate breast cancer metastasis [28]. CircRBMS3 promotes gastric cancer progression by regulating miR-153 [29]. In this study, we found that circMTO1 could directly bind to miR-182-5p.…”
Section: Discussionmentioning
confidence: 56%
“…Similarly, Zhong et al (13) demonstrated that circRNA transcription factor 25 (circTCF25) is upregulated in bladder carcinoma, and that circTCF25 downregulates miR-103a-3p, increases cyclin-dependent kinase 6 expression and promotes proliferation. Li et al (14) found that circRNA RNA-binding motif, single-stranded-interacting protein 3 (circRBMS3) is upregulated in gastric cancer, and that increased circRBMS3 expression is associated with advanced tumor-node-metastasis stage. Gao et al (15) reported that the circ_0006528/ miR-7-5p/Raf1 axis serves a key role in adriamycin-resistant breast cancer.…”
Section: Discussionmentioning
confidence: 99%
“…CircRBMS3 was increased in GC tissues, and its expression was closely related to advanced TNM stage and lymph-node metastasis. CircRBMS3 could promote gastric cancer cells proliferation and invasion by sponging miR-153 thereby upregulating SNAI1 expression (34). CircPDSS1 was increased in GC tissues and promoted GC cell cycle and inhibited apoptosis by sponging miR-186-5p and upregulating NEK2 expression (35).…”
Section: Circrna Serves As Mirna Sponges In Gcmentioning
confidence: 99%