CircRNA: A new class of targets for gastric cancer drug resistance therapy

Zheng, Ying; Li, Zhe; Wang, Yao; Chen, Wanjiao; Lin, Yifan; Guo, Junming; Ye, Guoliang

doi:10.3389/pore.2023.1611033

Cited by 14 publications

(4 citation statements)

References 77 publications

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“…It has been revealed that circRNAs cannot only affect the progression of gastrointestinal cancer, but also participate in their chemoresistance ( 102 ). A number of circRNAs have a role in drug resistance in GC, such as circ 0008253 and circ_0091741 ( 103 , 104 ).…”

Section: Biological Functions Of Exosomal Circrnas In Gastrointestina...mentioning

confidence: 99%

Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)

Xu,

Han,

Zhang

et al. 2023

Oncol Rep

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Gastrointestinal cancer is frequently detected at an advanced stage and has an undesirable prognosis due to the absence of efficient and precise biomarkers and therapeutic targets. Exosomes are small, living-cell-derived vesicles that serve a critical role in facilitating intercellular communication by transporting molecules from donor cells to receiver cells. circular RNAs (circRNAs) are mis-expressed in a variety of diseases, including gastrointestinal cancer, and are promising as diagnostic biomarkers and tumor therapeutic targets for gastrointestinal cancer. The main features of exosomes and circRNAs are discussed in the present review, along with research on the biological function of exosomal circRNAs in the development and progression of gastrointestinal cancer. It also assesses the advantages and disadvantages of implementing these findings in clinical applications.

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Section: Biological Functions Of Exosomal Circrnas In Gastrointestina...mentioning

confidence: 99%

Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)

Xu,

Han,

Zhang

et al. 2023

Oncol Rep

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“…Circular RNA (circRNA) has a great advantage in becoming a biomarker for human diseases, including cancer. [ 5,6 ] CircRNA plays a vital part in cancer progression and shows great potential in cancer diagnosis, prognosis and treatment. [ 7 ] CircRNA can be used as an oncogene to promote cancer progression, [ 8 ] or as a tumor suppressor to inhibit the malignant biological behaviors of cancer.…”

Section: Introductionmentioning

confidence: 99%

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Liu,

Wu,

Wang

et al. 2024

J Biochem & Molecular Tox

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Circular RNA is an important regulator for non‐small cell lung cancer (NSCLC). Circ_0000735 has been found to be significantly overexpressed in NSCLC tissues. Therefore, its role and mechanism in NSCLC progression need to be further explored. The expression levels of circ_0000735, miR‐345‐5p and A disintegrin and metalloprotease 19 (ADAM19) were determined using quantitative real‐time PCR. EdU staining, wound healing and transwell assays were utilized to detect cell proliferation and metastasis. The protein levels of metastasis markers, exosome markers and ADAM19 were determined using western blot. Animal experiments were performed to confirm the role of circ_0000735 in NSCLC tumorigenesis. The exosomes from cells and serum were identified using transmission electron microscopy and nanoparticle tracking analysis. We found that circ_0000735 was upregulated in NSCLC, and its knockdown repressed NSCLC cell proliferation and metastasis. In terms of mechanism, circ_0000735 targeted miR‐345‐5p to regulate ADAM19. MiR‐345‐5p inhibitor reversed the suppressive effect of circ_0000735 knockdown on NSCLC progression, and ADAM19 overexpression abolished the inhibition effect of miR‐345‐5p on NSCLC progression. Also, animal experiments showed that silencing of circ_0000735 reduced NSCLC tumorigenesis. In addition, exosomes mediated the intercellular transmission of circ_0000735, and serum exosomal circ_0000735 might be an important indicator for the diagnosis of NSCLC. In conclusion, circ_0000735 facilitated NSCLC progression via miR‐345‐5p/ADAM19 pathway, and serum exosomal circ_0000735 might be a potential biomarker for NSCLC diagnosis.

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“…Circular RNAs (circRNAs) are a special kind of noncoding RNA with a closed loop structure and extremely stable expression (10)(11)(12). The important regulatory effect of circRNA on cell biological functions in human disease has been confirmed (13)(14)(15)(16). For example, it was found that circ-HIPK2 could promote myocardial oxidative injury by increasing cell apoptosis and autophagy (17).…”

Section: Introductionmentioning

confidence: 99%

Circvma21-Related Pathway Alleviates Lipopolysaccharide-Induced Hk-2 Cell Injury

Li,

Fu,

Zeng

et al. 2024

Shock

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Background It is reported that circVMA21 has an inhibition effect on sepsis-induced acute kidney injury (AKI). Therefore, the underlying molecular mechanisms of circVMA21 in AKI are worthy of further investigation. Material and methods Lipopolysaccharide (LPS) was used to induce HK2 cell injury. CircVMA21, miR-337-3p and ZEB2 expression was tested by qRT-PCR. Cell growth was detected by CCK8 assay, EdU assay and flow cytometry. Protein levels were examined by western blot. The levels of inflammatory factors and oxidative stress markers were measured to evaluate cell inflammatory response and oxidative stress. RNA relationship as verified by dual-luciferase reporter assay, RIP assay and RNA pull-down assay. Results CircVMA21 had decreased expression in AKI patients. Overexpressed circVMA21 alleviated LPS-induced HK2 cell inflammation, apoptosis, and oxidative stress. Moreover, circVMA21 sponged miR-337-3p, and miR-337-3p targeted ZEB2. The inhibitory effect of circVMA21 on LPS-induced HK2 cell injury was reversed by miR-337-3p overexpression, and ZEB2 overexpression abolished the promotion effect of miR-337-3p on LPS-induced HK2 cell injury. Conclusions CircVMA21 could inhibit LPS-induced HK2 cell injury via miR-337-3p/ZEB2 axis.

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CircRNA: A new class of targets for gastric cancer drug resistance therapy

Cited by 14 publications

References 77 publications

Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)

Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Circvma21-Related Pathway Alleviates Lipopolysaccharide-Induced Hk-2 Cell Injury

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