CircRNA: Its biogenesis and role in skeletal muscle development

Abstract

Previously, circRNAs considered splicing errors during transcription, but recent studies uncovered that circRNA is a new group of noncoding RNAs. CircRNAs are produced through back splicing of pre mRNA and have more stability than linear RNA due to its closed loop structure. Numerous studies have unveiled the regulatory functions of circRNA in various biological mechanisms. Current literature has observed that circRNAs regulate the myogenesis of skeletal muscles through sponging miRNAs or acting as competitive endogenous RNA (CeRNA). Apart from myogenesis, it also regulates the functioning of different proteins at the molecular level and plays a key role during translation or protein encoding. All these facts have opened a new arena of research regarding the regulation of gene expression. This study aims to discuss the research advancements and new developments in the regulatory functions of circRNAs, including the development of skeletal muscle. This study also intends to discuss some newly discovered circRNAs involved in skeletal muscle development, especially in chicken and cattle.