circRNA meets gene amplification

Manguso, Nicholas; Giuliano, Armando E.; Tanaka, Hisashi

doi:10.21037/ncri.2018.06.04

Cited by 2 publications

(2 citation statements)

References 23 publications

(47 reference statements)

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“…In normal cells, the accumulation of nascent circRNAs contributes considerably to their detection at steady-state levels (Ashwal-Fluss et al, 2014; Zhang Y. et al, 2016), underlining the importance of circRNA biogenesis. This section is mainly focused on the effect of cancer-related genetic alterations, including single nucleotide variants (SNPs), genomic rearrangements, recurrent somatic mutations, and copy number alterations (Manguso et al, 2018), which modulate the expression of circRNAs through circRNA biogenesis. We discuss aberrant events in circRNA biogenesis in chronological order, and this section is divided into five subsections: aberrant cis -elements, aberrant chromosomes and genomes, aberrant transcription, aberrant spliceosomal machinery, and aberrant trans-acting factors.…”

Section: The Aberrant Regulation Of Circrnas In Cancermentioning

confidence: 99%

Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal

et al. 2019

Front. Genet.

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CircRNAs (circular RNAs) are a class of RNAs generated from circularization with multiple novel functions. Recent studies have revealed the aberrant expression and aberrant functions of circRNAs in various tumors; thus, circRNAs have been recognized as promising cancer biomarkers. However, the underlying mechanisms behind their aberrant expression and functions remain unclear. In this review, we discuss at length the cancer-specific deregulation of circRNAs and the potential underlying aberrant events in circRNA biogenesis, localization and removal in cancer cells.

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Section: The Aberrant Regulation Of Circrnas In Cancermentioning

confidence: 99%

Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal

et al. 2019

Front. Genet.

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“…For example, circFoxo3 can regulate p53-influenced immune responses by inducing the ubiquitination-dependent degradation of p53 through binding to MDM2 17 , 18 . Tumor cells may produce abnormal circRNAs caused by genetic mutations 19 , chromosomal translocation 20 , TGF-β signaling regulation 21 , and other aberrant events 22 . For example, PML/RARα chromosomal translocations lead to the generation of fusion circRNAs (F-circRNAs) in acute promyelocytic leukemia, which promote cellular transformation, cell viability, and resistance to therapy 23 .…”

Section: Introductionmentioning

confidence: 99%

Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy

Gao

Chen

et al. 2023

Nat Commun

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Circular RNAs (circRNAs) play important roles in the regulation of cancer. However, the clinical implications and regulatory networks of circRNAs in cancer patients receiving immune checkpoint blockades (ICB) have not been fully elucidated. Here, we characterize circRNA expression profiles in two independent cohorts of 157 ICB-treated advanced melanoma patients and reveal overall overexpression of circRNAs in ICB non-responders in both pre-treatment and early during therapy. Then, we construct circRNA-miRNA-mRNA regulatory networks to reveal circRNA-related signaling pathways in the context of ICB treatment. Further, we construct an ICB-related circRNA signature (ICBcircSig) score model based on progression-free survival-related circRNAs to predict immunotherapy efficacy. Mechanistically, the overexpression of ICBcircSig circTMTC3 and circFAM117B could increase PD-L1 expression via the miR-142-5p/PD-L1 axis, thus reducing T cell activity and leading to immune escape. Overall, our study characterizes circRNA profiles and regulatory networks in ICB-treated patients, and highlights the clinical utility of circRNAs as predictive biomarkers of immunotherapy.

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circRNA meets gene amplification

Cited by 2 publications

References 23 publications

Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal

Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal

Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy

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