circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

Xu, Qin; Deng, Bo; Li, Manlin; Chen, Yang; Zhuan, Li

doi:10.21203/rs.2.23146/v1

Cited by 8 publications

(11 citation statements)

References 7 publications

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“…Overexpression of miR-144 has a reverse effect on Circ-UBAP2 tumorigenesis [56]. Another study conducted on circ-UBAP2 showed that cell proliferation increases upon overexpression of circ-UBAP2 and cell apoptosis decreases via the miR-382-5p/PRPF8 pathway [57]. Deng et al found that ESRP1 overexpression is regulated by circ-0005585 via sponging of miR-15a, miR-15b, miR-16, miR-23a and miR-23b, which inhibited cancer cell migration and metastasis through alternative splicing of two cytoskeleton-associated proteins: EPB41L5 and Rac1 [58].…”

Section: Circrnas and Their Roles In Oc Pathogenesismentioning

confidence: 99%

CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

et al. 2021

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More powerful prognostic and diagnostic tools are urgently needed for identifying and treating ovarian cancer (OC), which is the most fatal malignancy in women in developed countries. Circular RNAs (circRNAs) are conservative and stable looped molecules that can regulate gene expression by competing with other endogenous microRNA sponges. This discovery provided new insight into novel methods for regulating genes that are involved in many disorders and cancers. This review focuses on the dysregulated expression of circRNAs as well as their diagnostic and prognostic values in OC. We found that studies have identified twenty-one downregulated circRNAs and fifty-seven upregulated ones. The results of these studies confirm that circRNAs might be potent biomarkers with diagnostic, prognostic and therapeutic target value for OC. We also consider the connection between circRNAs and OC cell proliferation, apoptosis, metastasis, and chemotherapy resistance and sensitivity.

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Section: Circrnas and Their Roles In Oc Pathogenesismentioning

confidence: 99%

CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

et al. 2021

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“…The expression of these molecules was associated with atherosclerotic vascular disease risk [ 49 ]. Importantly, numerous circRNAs were found to be overexpressed in the serum of OC patients, whereas others, such as circ_0051240, circ-HIPK3 (homeodomain interacting protein kinase 3), and circRNA-UBAP2 (ubiquitin associated protein 2), were implicated in the control of OC cells malignant behavior [ 50 , 51 ]. CircRNAs are more stable in cells than their linear counterparts due to their covalent closed-loop structure.…”

Section: Lncrna Genes and Their Expression Patternsmentioning

confidence: 99%

The Interplay between Long Noncoding RNAs and Proteins of the Epigenetic Machinery in Ovarian Cancer

Calanca

Abildgaard

Rainho

et al. 2020

Cancers

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Comprehensive large-scale sequencing and bioinformatics analyses have uncovered a myriad of cancer-associated long noncoding RNAs (lncRNAs). Aberrant expression of lncRNAs is associated with epigenetic reprogramming during tumor development and progression, mainly due to their ability to interact with DNA, RNA, or proteins to regulate gene expression. LncRNAs participate in the control of gene expression patterns during development and cell differentiation and can be cell and cancer type specific. In this review, we described the potential of lncRNAs for clinical applications in ovarian cancer (OC). OC is a complex and heterogeneous disease characterized by relapse, chemoresistance, and high mortality rates. Despite advances in diagnosis and treatment, no significant improvements in long-term survival were observed in OC patients. A set of lncRNAs was associated with survival and response to therapy in this malignancy. We manually curated databases and used bioinformatics tools to identify lncRNAs implicated in the epigenetic regulation, along with examples of direct interactions between the lncRNAs and proteins of the epigenetic machinery in OC. The resources and mechanisms presented herein can improve the understanding of OC biology and provide the basis for further investigations regarding the selection of novel biomarkers and therapeutic targets.

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“…Due to the lack of 3' poly (A) tail and 5' end cap, circRNAs are resistance to RNase R and are highly stable in vivo compared with linear RNA transcript [7]. Many studies have reported that circRNAs can serve as molecular sponge of microRNAs (miRNAs) to modulate gene expressions in the progression of cancers [8][9][10][11][12]. For example, circ-WHSC1 promotes the development of endometrial cancer by targeting miR-646 and up-regulating the expression of NPM1 [10].…”

Section: Introductionmentioning

confidence: 99%

Circular RNA circ-BNC2 (hsa_circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p/ FBXW7 axis

Liu

Zou

2022

J Ovarian Res

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Background Circular RNAs (circRNAs) are reported to be key regulators in the progression of human cancers. This work focuses on the function and molecular mechanism of circRNA-BNC2 (circ-BNC2) (also known as hsa_circ_0008732) in ovarian cancer (OC). Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to detect circ-BNC2, microRNA-223-3p (miR-223-3p) and F-box and WD repeat domain containing 7 (FBXW7) mRNA expressions in OC tissues and cells. Besides, cell counting kit 8 (CCK-8), transwell assay and cell cycle assays were executed to assess the proliferative, migrative, invasive abilities, and cell cycle progression of OC cells, respectively. Dual-luciferase reporter gene assay and RNA pull-down assay were used to validate the targeting relationships between miR-223-3p and circ-BNC2 or FBXW7. Western blot was adopted to determine FBXW7 protein levels in OC cells. Results Circ-BNC2 expression was downregulated in OC tissues and cell lines, which was associated with higher FIGO stage and lymph node metastasis of OC patients. Circ-BNC2 overexpression repressed the proliferation, migration, invasion of OC cells and induced cell cycle arrest, while silencing circ-BNC2 worked oppositely. Mechanistically, circ-BNC2 could upregulate FBXW7 expression in OC cells via sponging miR-223-3p. Conclusion Circ-BNC2 suppresses the progression of OC via regulating miR-223-3p / FBXW7 axis. Our findings provided potential biomarker for OC therapy.

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circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

Cited by 8 publications

References 7 publications

CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

The Interplay between Long Noncoding RNAs and Proteins of the Epigenetic Machinery in Ovarian Cancer

Circular RNA circ-BNC2 (hsa_circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p/ FBXW7 axis

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