CircRNAs: Emerging Bladder Cancer Biomarkers and Targets

Liang, Zhaofeng; Guo, Wenhao; Fang, Shikun; Zhang, Yue; Lü, Ling; Xu, Wenrong; Qian, Hui

doi:10.3389/fonc.2020.606485

Cited by 8 publications

(8 citation statements)

References 99 publications

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“…It is closely related to the occurrence and development of cancer. It can act as an mRNA 'sponge', regulate transcription and splicing, and interact with RNA-binding proteins (104). Most circRNA negatively regulates lymph node metastasis of bladder cancer, and some molecules positively regulate this process ( Figure 5).…”

Section: The Role Of Circrnas For Bca Lymph Node Metastasismentioning

confidence: 99%

Emerging Biomarkers for Predicting Bladder Cancer Lymph Node Metastasis

Zhang

et al. 2021

Front. Oncol.

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Bladder cancer is one of the leading causes of cancer deaths worldwide. Early detection of lymph node metastasis of bladder cancer is essential to improve patients’ prognosis and overall survival. Current diagnostic methods are limited, so there is an urgent need for new specific biomarkers. Non-coding RNA and m6A have recently been reported to be abnormally expressed in bladder cancer related to lymph node metastasis. In this review, we tried to summarize the latest knowledge about biomarkers, which predict lymph node metastasis in bladder cancer and their mechanisms. In particular, we paid attention to the impact of non-coding RNA on lymphatic metastasis of bladder cancer and its specific molecular mechanisms, as well as some prediction models based on imaging, pathology, and biomolecules, in an effort to find more accurate diagnostic methods for future clinical application.

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Section: The Role Of Circrnas For Bca Lymph Node Metastasismentioning

confidence: 99%

Emerging Biomarkers for Predicting Bladder Cancer Lymph Node Metastasis

Zhang

et al. 2021

Front. Oncol.

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“…7,8 Several studies have shown that circRNAs are implicated not only in various physiological and autoimmune diseases, but also playing an important role in multiple malignant tumorigeneses, cell proliferation, cell cycle, apoptosis, and metastases (migration and invasion). [9][10][11] Dysregulated circRNAs have been linked to a number of pathological processes, including cancer development. 12 For example, hsa_circ_0007031 promotes tumor progression and fosters 5-fluorouracil resistance in colorectal cancer by regulating the miR-133b/ABCC5 axis.…”

Section: Introductionmentioning

confidence: 99%

“…CircRNAs have a distinctive circular structure that enables them to act as miRNA sponges, control alternative splicing, bind to RNA‐binding proteins, and even encode proteins, thus regulating gene expression in a variety of ways 7,8 . Several studies have shown that circRNAs are implicated not only in various physiological and autoimmune diseases, but also playing an important role in multiple malignant tumorigeneses, cell proliferation, cell cycle, apoptosis, and metastases (migration and invasion) 9–11 . Dysregulated circRNAs have been linked to a number of pathological processes, including cancer development 12 .…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR‐1343‐3p/Bcl‐3 axis through TGFβ/Smad3/EMT signaling

Chen

Liu

et al. 2023

Molecular Carcinogenesis

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Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer‐related mortality worldwide. Circular RNAs (circRNAs) have been the focus of numerous studies, and some circRNAs have been linked to the development of multiple malignant tumors, including NSCLC. Nevertheless, the functional role and mechanisms of circRNAs in NSCLC remain largely unknown. The primary objective of this study was to screen the associated circRNA in NSCLC and investigate its mechanism. CircRNA microarray was used to identify circRNAs that were abnormally expressed in NSCLC tissue samples. Expression of hsa_circRNA_0088036 was validated in NSCLC tissues and cell lines after the correlation between hsa_circRNA_0088036 and prognosis was determined. We then used a series of function gain‐and‐loss assays to determine the role of hsa_circ_0088036 in NSCLC progression. RNA‐binding protein immunoprecipitation (RIP), RNA pull‐down, and RNA interference assays were used to assess the interaction between hsa_circ_0088036 and miR‐1343‐3p/Bcl‐3 axis. Moreover, mechanistic assays were applied to investigate the involved signaling pathway regulated by the hsa_circ_0088036/miR‐1343‐3p/Bcl‐3 axis. Microarray analysis and reverse transcription polymerase chain reaction confirmed the presence of a circRNA termed hsa_circ 0088036 that was upregulated in NSCLC tissue samples and cell lines and indicated a positive association with patient prognosis. Functionally, hsa_circ_0088036 silencing inhibited proliferative, invasive, and migrative potential of NSCLC cells as well as epithelial‐mesenchymal transition (EMT)‐related proteins by sponging miR‐1343‐3p to inhibit Bcl‐3. Furthermore, mechanistic experiments demonstrated that hsa_circ_0088036 promoted NSCLC progression by activating the TGFβ/Smad3/EMT signaling pathway via miR‐1343‐3p/Bcl‐3 axis. In conclusion, hsa_circ_0088036 functions as an oncogene by targeting the miR‐1343‐3p/Bcl‐3 axis via TGFβ/Smad3/EMT signaling pathway.

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“…In 2010, Poliseno et al first proposed the hypothesis of the interaction between protein-coding messenger RNAs (mRNAs) and ncRNAs [ 7 , 8 ] and circRNAs could act as ceRNAs [ 11 , 12 ]. Owing to the advantages of abundance, conservation, stability, and high specificity in serum, plasma, and other body fluids [ 13 , 14 ], circRNAs hold great potential as noninvasive blood-based biomarkers in cancer management [ 15 , 16 ]. A recent meta-analysis of the diagnostic efficacy of circRNAs in lung cancer tissues and blood suggested that circRNAs have diagnostic potential in the Chinese lung cancer population [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis

Yang

Tao

et al. 2022

Bioengineered

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Circular RNAs (circRNAs) are involved in the carcinogenesis of lung cancer. Human MYC gene is highly expressed in melanoma, multiple myeloma, and nasopharyngeal carcinoma. We aimed to investigate the role of circMYC in small cell lung cancer (SCLC). The expression of cirMYC in SCLC tissues and cells were examined. Functional studies were performed to evaluate the roles of circMYC in SCLC cells. Luciferase reporter gene assay, RNA pull-down assay, and rescue experiments were performed to evaluate the regulatory relationship between circMYC and miR-145, and MiR-145 and MMP2 mRNA. We found that CirMYC was highly expressed in SCLC tissues and cells. Knockdown of circMYC could inhibit cell proliferation, migration, invasion, and induce apoptosis. CircMYC targeted miR-145 and miR-145 targeted MMP2 (Matrix Metallopeptidase 2) mRNA. Our data indicated that circMYC upregulates the expression of MMP-2 by inhibiting miR-145, which functions to promote the proliferation, migration, and invasion and inhibit the apoptosis of SCLC. These findings suggest that targeting circMYC/miR-145/MMP-2 could serve as a potential therapeutic strategy for SCLC treatment.

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CircRNAs: Emerging Bladder Cancer Biomarkers and Targets

Cited by 8 publications

References 99 publications

Emerging Biomarkers for Predicting Bladder Cancer Lymph Node Metastasis

Emerging Biomarkers for Predicting Bladder Cancer Lymph Node Metastasis

Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR‐1343‐3p/Bcl‐3 axis through TGFβ/Smad3/EMT signaling

CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis

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