circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma

Matboli, Marwa; Shafei, Ayman; Ali, Mahmoud; Ashry, Ahmed M; Kamal, Kamal M; Agag, Mohammed Ali; Reda, Ibrahim; Tash, Eman Fathy; Ali, Marwa

doi:10.1002/jcb.28045

Cited by 33 publications

(25 citation statements)

References 50 publications

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“…For instance, hsa_circ_0091579 was significantly upregulated in tumor samples and related to poorer prognosis of HCC patients [51]. A recent study showed that the hsa_circ _00520 was associated with relapse-free survival and exhibited relatively high sensitivities and specificities compared with AFP [52]. Notably, circRNAs had been proved to be a type of non-invasive diagnosis markers for human cancers.…”

Section: Discussionmentioning

confidence: 99%

Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis

Huang

et al. 2020

J Exp Clin Cancer Res

292

198

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Background: Exosomes play crucial roles in regulating the crosstalk between normal and cancer cells in the tumor microenvironment, and in regulating cancer proliferation, migration and invasion through their cargo molecules. Methods: We analyzed the pro-invasiveness of exosomal circRNA-100,338 in HCC using the transwell invasion assay. The co-culture of human umbilical vein endothelial cells (HUVEC) and exosomes derived from HCC cell lines were used to evaluate the impact of HCC derived exosomes on HUVEC. Nude mice models were used to validate the findings in vitro. Clinically, quantitative RT-PCR was used to quantify the expression of serum exosomal circRNA-100,338 in HCC patients at both pre-surgery within one week and post-surgery within three weeks. Results: We aim to investigate the pro-invasive role of exosomal circRNA-100,338 in HCC metastasis. We for the first time demonstrated that circRNA-100,338 was highly expressed in both highly metastatic HCC cells and their secreted exosomes. The transwell invasion assay showed that the overexpression or knockdown of exosomal circRNA-100,338 significantly enhanced or reduced the invasive abilities of HCC cells. Subsequently, in vitro and in vivo assays showed that exosomal circRNA-100,338 affected the cell proliferation, angiogenesis, permeability, and vasculogenic mimicry (VM) formation ability of human umbilical vein endothelial cells (HUVEC), and tumor metastasis. Furthermore, we also observed that the persistent high expression of exosomal circRNA-100,338 in serum of HCC patients who underwent curative hepatectomy may be a risk indicator of pulmonary metastasis and poor survival. Conclusions: Our findings indicated that metastatic ability of HCC cells could be enhanced by transferring exosomal circRNA-100,338 to recipient HUVECs, which could affect proangiogenic activity by regulating angiogenesis.

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Section: Discussionmentioning

confidence: 99%

Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis

Huang

et al. 2020

J Exp Clin Cancer Res

292

198

View full text Add to dashboard Cite

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“…Has_circ_0090049 enhances cell proliferation and migration and suppresses cell apoptosis. Growing evidences indicate that some circRNAs, such as hsa_circ_00156 ( 73 ), hsa_circ_000224 ( 73 ), and hsa_circ_000520 ( 73 ), hsa_circ_0091579 ( 74 ), and hsa_circ_0128298 ( 75 ), are upregulated in HCC tissues or cells. But their biological functions or mechanisms of action still needed to be elucidated.…”

Section: Role Of Circrna In Hccmentioning

confidence: 99%

The Latest Overview of circRNA in the Progression, Diagnosis, Prognosis, Treatment, and Drug Resistance of Hepatocellular Carcinoma

Xiong

Dang

et al. 2021

Front. Oncol.

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Hepatocellular carcinoma (HCC) is one of the main causes of tumor-related deaths worldwide. Due to the lack of obvious early symptoms and the lack of sensitive screening indicators in the early stage of HCC, the vast majority of patients are diagnosed with advanced or metastatic HCC, resulting in dissatisfactory treatment result. Therefore, it is urgent to determine effective and sensitive diagnostic and prognostic indicators and to determine new therapeutic targets. Circular RNA (circRNA) is a type of non-coding RNA that has been neglected for a long time. In recent years, it has been proved to play an important role in the development of many human diseases. Increasing evidence shows that change in circRNA expression has an extensive effect on the biological behavior of HCC. In this study, we comprehensively tracked the latest progress of circRNA in the pathogenesis of HCC, and reviewed its role as a biomarker for diagnosis and prognosis prediction in patients with HCC. In addition, we also summarized the potential of circRNA as therapeutic target in HCC and its relationship with HCC drug resistance, providing clues for the clinical development of circRNA-based therapeutic strategies.

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“…Several studies have reported abnormal expression of circ_000244, circ_104075, circ_000520, cSMARCA5, and circ_001565 in the serum/plasma of HCC and clarified the diagnostic performance of these circRNAs in HCC (110)(111)(112)(113)(114)(115). Zhang et al revealed that HCC tissues and serum circ_104075 were highly expressed as compared with the control group.…”

Section: Circular Rnasmentioning

confidence: 99%

Peripheral Blood Genetic Biomarkers for the Early Diagnosis of Hepatocellular Carcinoma

Song

et al. 2021

Front. Oncol.

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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and has high mortality. Biomarkers related to HCC, such as alpha-fetoprotein, and imaging technology, such as ultrasound and computed tomography, have been used to screen and monitor HCC, but HCC is still difficult to diagnose effectively in the early stage due to the low sensitivity of the above mentioned traditional methods. There is an urgent need for noninvasive biomarkers to facilitate the screening and early diagnosis of HCC. With the advancement of next-generation sequencing, genetic biomarkers are becoming the core of cancer diagnosis. Genetic biomarkers such as peripheral blood circulating tumor DNA, microRNAs, long noncoding RNAs, circular RNAs, and exosomes have become the focus of early HCC diagnostics. HCC genetic biomarkers have been implemented in clinical practice. In this review, we describe the available literature on peripheral blood genetic biomarkers in the diagnosis of early HCC.

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circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma

Cited by 33 publications

References 50 publications

Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis

Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis

The Latest Overview of circRNA in the Progression, Diagnosis, Prognosis, Treatment, and Drug Resistance of Hepatocellular Carcinoma

Peripheral Blood Genetic Biomarkers for the Early Diagnosis of Hepatocellular Carcinoma

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