CircRnas in atherosclerosis, with special emphasis on the spongy effect of circRnas on miRnas

Cheng, Chenglong; Wang, Yuting; Xue, Qiuyun; Huang, Yurong; Wang, Xiao; Liao, Faxue; Miao, Chenggui

doi:10.1080/15384101.2022.2133365

Cited by 5 publications

(4 citation statements)

References 96 publications

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“…Endothelial cell injury and dysfunction (including inhibition of cell proliferation, cell migration, and angiogenesis) and proliferation of vascular smooth muscle cells can exacerbate AS. 44 In addition to LDL/HDL particles deposition and inflammation can also contribute to AS, and altered macrophage cell function affects the AS. 45 There is a large body of evidence that circRNA play an important role in atherogenesis and progression of AS by regulating ECs, VSMCs, and macrophages through sponge function or interaction with proteins (Table 1).…”

Section: Circrna In Asmentioning

confidence: 99%

“…Many cells are involved in participating in this process, vascular endothelial cells and vascular smooth muscle cells are the two main cell types involved in the pathogenesis of AS. Endothelial cell injury and dysfunction (including inhibition of cell proliferation, cell migration, and angiogenesis) and proliferation of vascular smooth muscle cells can exacerbate AS 44 . In addition to LDL/HDL particles deposition and inflammation can also contribute to AS, and altered macrophage cell function affects the AS 45 .…”

Section: The Functional Role Of Circrna In Cvdmentioning

confidence: 99%

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Circular RNA: A new expectation for cardiovascular diseases

Xie,

Ma,

Ren

et al. 2023

J of Cellular Biochemistry

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Circular RNA (circRNA) is a class of RNA with the 5' and 3' ends connected covalently to form a closed loop structure and characterized by high stability, conserved sequences and tissue specificity, which is caused by special reverse splicing methods. Currently, it has become a hot spot for research. With the discovery of its powerful regulatory functions and roles, the molecular mechanisms and future value of circRNA in participating in and regulating biological and pathological processes are becoming increasingly apparent. Among them is the increasing prevalence of cardiovascular diseases (CVDs). Many studies have elucidated that circRNA plays a crucial role in the development and progression of CVDs. Therefore, circRNA shows its advantages and brilliant expectations in the field of CVDs. In this review, we describe the biogenesis, bioinformatics detection and function of circRNA and discuss the role of circRNA and its effects on CVDs, including atherosclerosis, myocardial infarction, cardiac hypertrophy and heart failure, myocardial fibrosis, cardiac senescence, pulmonary hypertension, and diabetic cardiomyopathy by different mechanisms. That shows circRNA advantages and brilliant expectations in the field of CVDs.

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Section: Circrna In Asmentioning

confidence: 99%

Section: The Functional Role Of Circrna In Cvdmentioning

confidence: 99%

Circular RNA: A new expectation for cardiovascular diseases

Xie,

Ma,

Ren

et al. 2023

J of Cellular Biochemistry

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“…These biological processes are regulated by multiple signaling pathways and molecular mechanisms, including the involvement of non-coding RNAs (ncRNAs). Recent studies have highlighted the significant regulatory roles of ncRNAs, such as lncRNAs and circRNAs, in the development and progression of atherosclerosis [123,124]. These ncRNAs can impact AS progression by regulating various biological processes, including cell proliferation, apoptosis, inflammatory response, and extracellular matrix synthesis and degradation [125,126].…”

Section: Atherosclerosis (As)mentioning

confidence: 99%

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Jiang¹,

Hu²

2023

Clin. transl. rep.

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Cardiovascular and cerebrovascular diseases (CVD) encompass a range of conditions affecting the heart, brain, and blood vessels, including coronary heart disease, hypertension, and stroke. In recent years, there has been growing evidence highlighting the significant role of non-coding RNAs (ncRNAs) in the development and progression of cardiovascular diseases. Among the various types of ncRNAs, long-stranded non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have emerged as prominent players in cardiovascular research. Advancements in technology and in-depth research have revealed that ncRNAs and circRNAs exert regulatory effects on the biological functions of the cardiovascular system through various pathways. For instance, they can modulate the proliferation, migration, and apoptosis of vascular endothelial cells, as well as regulate cardiac muscle contraction and cardiomyocyte apoptosis. Additionally, ncRNAs and circRNAs can influence downstream targets and pathways involved in cardiovascular diseases. The exploration of ncRNAs and circRNAs in cardiovascular research has opened up new avenues for the diagnosis and treatment of CVDs. By understanding the intricate regulatory mechanisms mediated by these non-coding RNAs, researchers have gained valuable insights into the pathogenesis of cardiovascular diseases and identified potential therapeutic targets. Consequently, these studies have provided novel ideas and approaches for the diagnosis, prevention, and management of CVDs.

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“…It is believed that miRNAs can regulate more than half of the genes encoding human proteins [ 8 ]. By inhibiting the expression of genes involved in reverse cholesterol transport in macrophages, miRNAs play a key role in the regulation of lipid disorders and atherogenesis [ 9 , 10 , 11 , 12 , 13 , 14 ]. Since complementarity of 6–8 bases is sufficient to form a miRNA/mRNA duplex, a single miRNA molecule can target a wide range of different mRNAs, while a single mRNA can be attacked by several miRNAs.…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs Variously Participate in Coronary Atherogenesis

Dergunova,

Vinogradina,

Filippenkov

et al. 2023

CIMB

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Over the past decade, numerous studies have shown that circular RNAs (circRNAs) play a significant role in coronary artery atherogenesis and other cardiovascular diseases. They belong to the class of non-coding RNAs and arise as a result of non-canonical splicing of premature RNA, which results in the formation of closed single-stranded circRNA molecules that lack 5′-end caps and 3′-end poly(A) tails. circRNAs have broad post-transcriptional regulatory activity. Acting as a sponge for miRNAs, circRNAs compete with mRNAs for binding to miRNAs, acting as competing endogenous RNAs. Numerous circRNAs are involved in the circRNA–miRNA–mRNA regulatory axes associated with the pathogenesis of cardiomyopathy, chronic heart failure, hypertension, atherosclerosis, and coronary artery disease. Recent studies have shown that сirc_0001445, circ_0000345, circ_0093887, сircSmoc1-2, and circ_0003423 are involved in the pathogenesis of coronary artery disease (CAD) with an atheroprotective effect, while circ_0002984, circ_0029589, circ_0124644, circ_0091822, and circ_0050486 possess a proatherogenic effect. With their high resistance to endonucleases, circRNAs are promising diagnostic biomarkers and therapeutic targets. This review aims to provide updated information on the involvement of atherogenesis-related circRNAs in the pathogenesis of CAD. We also discuss the main modern approaches to detecting and studying circRNA–miRNA–mRNA interactions, as well as the prospects for using circRNAs as biomarkers and therapeutic targets for the treatment of cardiovascular diseases.

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CircRnas in atherosclerosis, with special emphasis on the spongy effect of circRnas on miRnas

Cited by 5 publications

References 96 publications

Circular RNA: A new expectation for cardiovascular diseases

Circular RNA: A new expectation for cardiovascular diseases

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Circular RNAs Variously Participate in Coronary Atherogenesis

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