circRNAs in Cancer

Patop, Inés Lucía; Kadener, Sebastián

doi:10.1016/j.gde.2017.11.007

Cited by 403 publications

(340 citation statements)

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“…Numerous studies have demonstrated that circRNAs can play a regulatory part in the translation and binding of miRNAs and so forth (Beermann, Piccoli, Viereck, & Thum, 2016). On the other side, increasing evidence have proved circRNAs are involved in a variety of carcinoma activities, like viability, apoptosis, and so on (Patop & Kadener, 2018). circFNDC3B is a circRNA shears from FNDC3B, which has been presented to play a promoting or restraining efficacy in carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Retracted: Circular RNA circFNDC3B protects renal carcinoma by miR‐99a downregulation

Chen

Shao

et al. 2019

Journal Cellular Physiology

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Various circular RNAs (circRNAs) have been reported to involve in carcinoma. This study explored the role and mechanism of circRNA circFNDC3B (circFNDC3B) in renal carcinoma (RC). The detection indicators in this paper were viability, colony, and migration, which respectively investigated by Cell Counting Kit-8, colony formation, and migration assay. Reverse transcriptase quantitative polymerase chain reaction tested and cell transfection changed circFNDC3B and miR-99a expression. Moreover, western blot tested relate-proteins of proliferation, migration, and cell pathways were examined by western blot. circFNDC3B was upregulated at RC tissues. circFNDC3B enhanced cell viability, colony and migration, and miR-99a mimic played reverse impacts. Furthermore, circFNDC3B negatively regulated miR-99aand circFNDC3B restrained the janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathways by miR-99a downregulation.Overexpression of circFNDC3B enhanced cell viability, colony formation and migration by miR-99a downregulation via JAK1/STAT3 and MEK/ERK pathways. K E Y W O R D ScircFNDC3B, migration, miR-99a, renal carcinoma, viability

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Section: Introductionmentioning

confidence: 99%

Retracted: Circular RNA circFNDC3B protects renal carcinoma by miR‐99a downregulation

Chen

Shao

et al. 2019

Journal Cellular Physiology

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“…A subset of circRNA produces proteins in the fly brain and in murine and human cells Pamudurti et al, 2017;Yang et al, 2017), and others seem to be related to the immune response (Li et al, 2017a;Liu et al, 2019). In addition, a number of studies suggest an association between circRNAs and cancer (reviewed in Kristensen et al, 2018;Patop & Kadener, 2018). In addition, a number of studies suggest an association between circRNAs and cancer (reviewed in Kristensen et al, 2018;Patop & Kadener, 2018).…”

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confidence: 99%

“…Several reports demonstrated in vivo functions for circRNAs in the mouse and fly brains, as well as in bone marrow (Piwecka et al, 2017;Kleaveland et al, 2018;Xia et al, 2018;Data ref: Pamudurti et al, 2018). In addition, a number of studies suggest an association between circRNAs and cancer (reviewed in Kristensen et al, 2018;Patop & Kadener, 2018). These developments show a clear change of view in the scientific community toward circRNAs, representing a turning point in this exciting and rapidly developing field.…”

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confidence: 99%

Past, present, and future of circ RNA s

2019

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Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue‐specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in cis as back‐splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in trans: Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field.

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“…It is clear that circRNAs have an important function in progression and development of cancer and influence cancer markers . But, the roles of circRNAs in NSCLC are largely unclear.…”

Section: Discussionmentioning

confidence: 99%

“…It is clear that circRNAs have an important function in progression and development of cancer and influence cancer markers. [25][26][27][28] But, the roles of circRNAs in NSCLC are largely unclear. In the current investigation, we confirmed that circPIP5K1A was upregulated in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circPIP5K1A promotes non‐small cell lung cancer proliferation and metastasis through miR‐600/HIF‐1α regulation

Chi

Luo

Song

et al. 2019

J of Cellular Biochemistry

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Circular RNAs (circRNAs) have an important function in human diseases, especially in cancer. circRNA hsa_circ_0014130 (circPIP5K1A), a particularly abundant circRNA, participates in the tumorigenesis of non‐small cell lung cancer (NSCLC), although the underlying regulatory mechanism remains unclear. Here, we investigated the circPIP5K1A role in NSCLC. Expression of circPIP5K1A in NSCLC cell lines was explored with quantitative real‐time PCR. The effect of circPIP5K1A on NSCLC was evaluated with circPIP5K1A silencing, miR‐600 mimic transfection, and hypoxia‐inducible factor (HIF)‐1α overexpression, followed by assessment of cell proliferation, metastasis, and tumorigenesis in nude mice. The subcellular localization of circPIP5K1A was evaluated via fluorescence in situ hybridization (FISH), and correlation between circPIP5K1A, miR‐600, and HIF‐1α was assessed by luciferase assay. The data demonstrated that circPIP5K1A expression was increased in NSCLC cells. FISH showed that circPIP5K1A localized to the cytoplasm. The circPIP5K1A knockdown suppressed NSCLC cell metastasis and proliferation by promoting expression of miR‐600. Overexpression of miR‐600 inhibited HIF‐1α‐mediated metastasis and proliferation of NSCLC cell by downregulating the endothelial mesenchymal transition‐related proteins, Snail and vimentin, and upregulating E‐cadherin. In vivo experiments illustrated that circPIP5K1A silence suppressed tumor growth and pulmonary metastasis. The circPIP5K1A may function as an miR‐600 sponge to facilitate NSCLC proliferation and metastasis by promoting HIF‐1α. A bifluorescein reporter experiment confirmed that miR‐600 was the circPIP5K1A target, and miR‐600 interacted with the 3′ untranslated region of HIF‐1α. These results show that circPIP5K1A acted as a tumor promoter through a novel circPIP5K1A/miR‐600/HIF‐1α axis, which provides candidate markers and therapeutic targets for NSCLC.

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circRNAs in Cancer

Cited by 403 publications

References 50 publications

Retracted: Circular RNA circFNDC3B protects renal carcinoma by miR‐99a downregulation

Retracted: Circular RNA circFNDC3B protects renal carcinoma by miR‐99a downregulation

Past, present, and future of circ RNA s

Circular RNA circPIP5K1A promotes non‐small cell lung cancer proliferation and metastasis through miR‐600/HIF‐1α regulation

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