CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease

Cheng, Quancheng; Wang, Jianwei; Li, Man; Fang, Jinyu; Ding, Hong; Meng, Jieyi; Zhang, Junwei; Fang, Xuan; Liu, Huaicun; Ma, Chao; Chen, Chunhua; Zhang, Weiguang

doi:10.1016/j.redox.2022.102430

Cited by 38 publications

(28 citation statements)

References 58 publications

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“…In the PD model, circSV2b overexpression can reduce oxidative stress injury, protect dopaminergic neuron loss, maintain nigrostriatal function, and improve motor defects through miR‐5107‐5p‐FOXK1‐AKT1 signaling pathways. CircSV2b may help to better understand the pathogenesis of PD and become the new target for the diagnosis and treatment of PD 126 . These findings provide valuable potential biomarkers for evaluating treatment strategies for PD.…”

Section: Exosomes In Neuropsychiatric Disordersmentioning

confidence: 99%

“…In the M2 microglia, exosomal miR‐124 reduces the formation of glial scar after stroke by inhibiting the expression of signal transducer and activator of transcription 3 (STAT3), promotes poststroke recovery, and alleviates the migration and proliferation of astrocytes 124,125 . In Parkinson's disease (PD) model, circSV2b overexpression can reduce oxidative stress injury, protect dopaminergic neuron loss, maintain nigrostriatal function, and improve motor defects through miR‐5107‐5p‐FOXK1 (fork‐head box protein K1)‐AKT1 (serine/threonine protein kinase) signaling pathways 126 . miR‐215 targets the apoptosis‐related genes (BCL2L11 and SIRT1) and functions to regulate the AMPK‐SIRT1‐TFEB (adenosine 5′‐monophosphate [AMP] activated protein kinase [AMPK]‐silent message regulatory factor 1‐transcription factor EB) signaling pathway and prevent neuronal apoptosis.…”

Section: Exosomesmentioning

confidence: 99%

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Exosomes in brain diseases: Pathogenesis and therapeutic targets

Pang

et al. 2023

MedComm

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Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally secreted by cells into body fluids. They are derived from endosomes and are wrapped in lipid membranes. Exosomes are involved in intracellular metabolism and intercellular communication. They contain nucleic acids, proteins, lipids, and metabolites from the cell microenvironment and cytoplasm. The contents of exosomes can reflect their cells’ origin and allow the observation of tissue changes and cell states under disease conditions. Naturally derived exosomes have specific biomolecules that act as the “fingerprint” of the parent cells, and the contents changed under pathological conditions can be used as biomarkers for disease diagnosis. Exosomes have low immunogenicity, are small in size, and can cross the blood–brain barrier. These characteristics make exosomes unique as engineering carriers. They can incorporate therapeutic drugs and achieve targeted drug delivery. Exosomes as carriers for targeted disease therapy are still in their infancy, but exosome engineering provides a new perspective for cell‐free disease therapy. This review discussed exosomes and their relationship with the occurrence and treatment of some neuropsychiatric diseases. In addition, future applications of exosomes in the diagnosis and treatment of neuropsychiatric disorders were evaluated in this review.

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Section: Exosomes In Neuropsychiatric Disordersmentioning

confidence: 99%

Section: Exosomesmentioning

confidence: 99%

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Pang

et al. 2023

MedComm

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“…Unfortunately, the results of this study were derived from bioinformatic analysis alone; additional experimental studies are required to validate these findings. Cheng et al (2022) performed ribosomal RNA-depleted RNAseq on SN pars compacta and striatum tissue from a PD mouse model as well as paired control tissue and found that circSV2b was downregulated. They then used a bioinformatic database to predict the target miRNAs of circSV2b as well as its downstream mRNAs and discovered that miR-5107-5p and Foxk1 were the targeted factors of circSV2b and miR-5107-5p, respectively (Cheng et al, 2022).…”

Section: Circrnas In Oxidative Stressmentioning

confidence: 99%

“…Cheng et al (2022) performed ribosomal RNA-depleted RNAseq on SN pars compacta and striatum tissue from a PD mouse model as well as paired control tissue and found that circSV2b was downregulated. They then used a bioinformatic database to predict the target miRNAs of circSV2b as well as its downstream mRNAs and discovered that miR-5107-5p and Foxk1 were the targeted factors of circSV2b and miR-5107-5p, respectively (Cheng et al, 2022). Because oxidative stress plays a crucial role in the cascade leading to DA cell degeneration in both familial and sporadic PD, they further screened for genes associated with oxidative stress downstream of Foxk1 and identified that Akt1 (an intermediate regulatory molecule of Foxk1) was involved in PD.…”

Section: Circrnas In Oxidative Stressmentioning

confidence: 99%

“…Because oxidative stress plays a crucial role in the cascade leading to DA cell degeneration in both familial and sporadic PD, they further screened for genes associated with oxidative stress downstream of Foxk1 and identified that Akt1 (an intermediate regulatory molecule of Foxk1) was involved in PD. Their mechanistic analysis demonstrated that circSV2b overexpression leads to reduced oxidative stress damage through the miR-5107-5p/Foxk1/Akt1 axis in PD models (Cheng et al, 2022).…”

Section: Circrnas In Oxidative Stressmentioning

confidence: 99%

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The emerging role of circular RNAs in Parkinson’s disease

Liao

Zhang

Huang³

et al. 2023

Front. Neurosci.

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Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and the most common movement disorder. It involves a gradual loss of dopaminergic neurons in the substantia nigra. Although many studies have been conducted, the underlying molecular pathways of PD remain largely unknown. Circular RNAs (circRNAs), a novel class of non-coding RNAs with a covalently closed loop structure, are common in the brain. They are stable, conserved molecules that are widely expressed in eukaryotes in tissue-, cell-, and development-specific patterns. Many circRNAs have recently been identified in nervous system diseases, and some circRNA expression profiles have been linked to PD. Given that recent research has indicated the essential roles of various circRNAs in the development and progression of neurodegenerative diseases, the identification of individual circRNAs may be a promising strategy for finding new treatment targets for PD. Moreover, the search for circRNAs with high specificity and sensitivity will open up new avenues for the early diagnosis and treatment of PD. Herein, we address the biogenesis, properties, and roles of circRNAs and review their potential utility as biomarkers and therapeutic targets in PD.

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circPPP2R4 promotes colorectal cancer progression and reduces ROS production through the miR‐646/FOXK1 axis

Hong,

Chen,

Wang

et al. 2023

Molecular Carcinogenesis

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Circular RNAs (circRNAs) play important roles in colorectal cancer (CRC) development and progression. This study aimed to investigate the function and molecular mechanism of circPPP2R4 in CRC. Based on bioinformatic analyses and validation by qRT‐PCR, we identified a novel circRNA, circPPP2R4, which was upregulated in CRC tissues. Receiver operating characteristic curve analysis implied a high diagnostic value of circPPP2R4 for CRC. Additionally, high circPPP2R4 levels were positively correlated with advanced clinical stage and lymph node metastasis. Functionally, circPPP2R4 overexpression facilitated CRC cells proliferation, migration and invasion, whereas circPPP2R4 knockdown attenuated the malignant behaviors. In mouse models, circPPP2R4 overexpression remarkably promoted tumor growth and lung metastasis. Mechanistically, a series of experiments containing RIP, RNA pull‐down, and dual‐luciferase reporter assays revealed the circPPP2R4/miR‐646/FOXK1 axis in CRC. Further experiments were conducted to verify that circPPP2R4 reduced reactive oxygen species generation to exert its oncogenic function by sponging miR‐646 to upregulate FOXK1 expression. For the first time, we identified the regulatory role of circPPP2R4 in CRC pathogenesis, providing a potential diagnostic biomarker and therapeutic strategy for CRC.

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CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease

Cited by 38 publications

References 58 publications

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Exosomes in brain diseases: Pathogenesis and therapeutic targets

The emerging role of circular RNAs in Parkinson’s disease

circPPP2R4 promotes colorectal cancer progression and reduces ROS production through the miR‐646/FOXK1 axis

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