Circuit organization of the rodent medial prefrontal cortex

Anastasiades, Paul G.; Carter, Adam G.

doi:10.1016/j.tins.2021.03.006

Cited by 169 publications

(146 citation statements)

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“…Cortical inhibitory interneuron types not only exhibit specificity for a particular cellular region when forming synaptic connections during development but also exhibit cell-typebiased synaptic targeting. As cell types among cortical pyramidal neurons have become better defined, instances of striking specificity in inhibitory targeting of pyramidal neuron subtypes have been identified (Krook-Magnuson et al, 2012;Anastasiades and Carter, 2021). For example, although some studies showed that innervation of pyramidal neurons by PV basket cells and SST Martinotti cells is consistent with Peters' Rule (Fino and Yuste, 2011;Packer and Yuste, 2011), PV neurons in the mouse medial prefrontal cortex (mPFC) have a higher connection probability with L5 PT cells than IT pyramids (Lee et al, 2014;Anastasiades et al, 2018).…”

Section: Cell-type-biased Connections From Inhibitory Interneurons To Pyramidal Neuronsmentioning

confidence: 99%

“…In addition to forming synapses onto specific neuronal domains and types of cortical excitatory neurons, inhibitory interneurons form cell-type-specific inhibitory networks within the neocortex (Hestrin and Galarreta, 2005;Tremblay et al, 2016;Fishell and Kepecs, 2020;Anastasiades and Carter, 2021). Although the molecular mechanisms underlying the development of these stereotyped patterns of connectivity remain unclear, the increasing availability of genetic tools for identifying and manipulating interneuron subtypes make them potentially tractable systems for investigating molecular recognition mechanisms in neocortical development.…”

Section: Cell-type-specific Inhibitory Networkmentioning

confidence: 99%

“…. The neocortex is traditionally divided into six layers, and each cortical layer is composed of different sets of these neuronal cell types (Callaway, 1998;Thomson and Lamy, 2007;Feldmeyer, 2012;Harris and Mrsic-Flogel, 2013;Harris and Shepherd, 2015;Anastasiades and Carter, 2021;Staiger and Petersen, 2021), most of which also send dendrites and intracortical axons outside their home layer. The function of the mature neocortex relies on stereotyped patterns of intracortical connections among these neuronal cell types both within and across layers as well as predictable properties of their synaptic connections (Thomson and Lamy, 2007;Feldmeyer, 2012;Harris and Shepherd, 2015;Kubota et al, 2016;Tremblay et al, 2016;Adesnik and Naka, 2018;Anastasiades and Carter, 2021;Staiger and Petersen, 2021).…”

mentioning

confidence: 99%

“…The neocortex is traditionally divided into six layers, and each cortical layer is composed of different sets of these neuronal cell types (Callaway, 1998;Thomson and Lamy, 2007;Feldmeyer, 2012;Harris and Mrsic-Flogel, 2013;Harris and Shepherd, 2015;Anastasiades and Carter, 2021;Staiger and Petersen, 2021), most of which also send dendrites and intracortical axons outside their home layer. The function of the mature neocortex relies on stereotyped patterns of intracortical connections among these neuronal cell types both within and across layers as well as predictable properties of their synaptic connections (Thomson and Lamy, 2007;Feldmeyer, 2012;Harris and Shepherd, 2015;Kubota et al, 2016;Tremblay et al, 2016;Adesnik and Naka, 2018;Anastasiades and Carter, 2021;Staiger and Petersen, 2021). Although much progress has been made in identifying mechanisms regulating cell-type-specific synapse formation in other brain areas and model organisms (Kolodkin and Tessier-Lavigne, 2011;Rawson et al, 2017;Favuzzi and Rico, 2018;Apostolo and De Wit, 2019;Kast and Levitt, 2019;Agi et al, 2020;Honig and Shapiro, 2020;Sanes and Zipursky, 2020), how the synaptic organization of intracortical connections arises during development to generate the circuits of the mature mammalian neocortex is only beginning to be understood.…”

mentioning

confidence: 99%

“…During development, the intracortical axons and dendrites of cortical cell types reach their appropriate laminar destinations (Larsen and Callaway, 2006;Fame et al, 2011;Gibson and Ma, 2011;Kalil and Dent, 2014;Hand et al, 2015;Dorskind and Kolodkin, 2021), and there encounter multiple classes of synaptic targets. They must then select the correct cell types and postsynaptic domains within those cell types with which to form synaptic connections (Thomson and Lamy, 2007;Brown and Hestrin, 2009a;Krook-Magnuson et al, 2012;Harris and Shepherd, 2015;Kubota et al, 2016;Tremblay et al, 2016;Chevée and Brown, 2018;Kast and Levitt, 2019;Anastasiades and Carter, 2021). The appropriate synaptic machinery must also be recruited to the pre-and postsynaptic membranes to establish synaptic properties specific to each connection type (Larsen and Sjöström, 2015;Nusser, 2018;Südhof, 2018;Sanes and Zipursky, 2020).…”

mentioning

confidence: 99%

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Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits

Gutman-Wei

Brown

2021

Front. Neural Circuits

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The cerebral cortex contains numerous neuronal cell types, distinguished by their molecular identity as well as their electrophysiological and morphological properties. Cortical function is reliant on stereotyped patterns of synaptic connectivity and synaptic function among these neuron types, but how these patterns are established during development remains poorly understood. Selective targeting not only of different cell types but also of distinct postsynaptic neuronal domains occurs in many brain circuits and is directed by multiple mechanisms. These mechanisms include the regulation of axonal and dendritic guidance and fine-scale morphogenesis of pre- and postsynaptic processes, lineage relationships, activity dependent mechanisms and intercellular molecular determinants such as transmembrane and secreted molecules, many of which have also been implicated in neurodevelopmental disorders. However, many studies of synaptic targeting have focused on circuits in which neuronal processes target different lamina, such that cell-type-biased connectivity may be confounded with mechanisms of laminar specificity. In the cerebral cortex, each cortical layer contains cell bodies and processes from intermingled neuronal cell types, an arrangement that presents a challenge for the development of target-selective synapse formation. Here, we address progress and future directions in the study of cell-type-biased synaptic targeting in the cerebral cortex. We highlight challenges to identifying developmental mechanisms generating stereotyped patterns of intracortical connectivity, recent developments in uncovering the determinants of synaptic target selection during cortical synapse formation, and current gaps in the understanding of cortical synapse specificity.

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Section: Cell-type-biased Connections From Inhibitory Interneurons To Pyramidal Neuronsmentioning

confidence: 99%

Section: Cell-type-specific Inhibitory Networkmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits

Gutman-Wei

Brown

2021

Front. Neural Circuits

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Clinical features and power spectral entropy of electroencephalography in Wilson's disease with dystonia

et al. 2022

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Objective To study the clinical features and power spectral entropy (PSE) of electroencephalography signals in Wilson's disease (WD) patients with dystonia. Methods Several scale evaluations were performed to assess the clinical features of WD patients. Demographic information and electroencephalography signals were obtained in all subjects. Results 34 WD patients with dystonia were recruited in the case group and 24 patients without dystonia were recruited in the control group. 20 healthy individuals were included in the healthy control group. The mean body mass index (BMI) in the case group was significantly lower than that in the controls (p < .05). The case group had significantly higher SAS, SDS, and Bucco‐Facial‐Apraxia Assessment scores (p < .05). Total BADS scores in the case group were lower than those in the control group (p < .01). Note that 94.11% of the case group presented with dysarthria and 70.59% of them suffered from dysphagia. Dysphagia was mainly related to the oral preparatory stage and oral stage. Mean power spectral entropy (PSE) values in the case group were significantly different (p < .05) from those in the control group and the healthy group across the different tasks. Conclusions The patients with dystonia were usually accompanied with low BMI, anxiety, depression, apraxia, executive dysfunction, dysarthria and dysphagia. The cortical activities of the WD patients with dystonia seemed to be more chaotic during the eyes‐closed and reading tasks but lower during the swallowing stages than those in the control group.

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Subclass‐specific expression patterns of MET receptor tyrosine kinase during development in medial prefrontal and visual cortices

Lanjewar

Jagetia

Khan

et al. 2022

J of Comparative Neurology

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Met encodes a receptor tyrosine kinase (MET) that is expressed during development and regulates cortical synapse maturation. Conditional deletion of Met in the nervous system during embryonic development leads to deficits in adult contextual fear learning, a medial prefrontal cortex (mPFC)‐dependent cognitive task. MET also regulates the timing of critical period plasticity for ocular dominance in primary visual cortex (V1). However, the underlying circuitry responsible remains unknown. Therefore, this study determines the broad expression patterns of MET throughout postnatal development in mPFC and V1 projection neurons (PNs), providing insight into similarities and differences in the neuronal subtypes and temporal patterns of MET expression between cortical areas. Using a transgenic mouse line that expresses green fluorescent protein (GFP) in Met+ neurons, immunofluorescence and confocal microscopy were performed to visualize MET‐GFP+ cell bodies and PN subclass‐specific protein markers. Analyses reveal that the MET expression is highly enriched in infragranular layers of mPFC, but in supragranular layers of V1. Interestingly, temporal regulation of the percentage of MET+ neurons across development not only differs between cortical regions but also is distinct between lamina within a cortical region. Further, MET is expressed predominantly in the subcerebral PN subclass in mPFC, but the intratelencephalic PN subclass in V1. The data suggest that MET signaling influences the development of distinct circuits in mPFC and V1 that underlie subcerebral and intracortical functional deficits following Met deletion, respectively.

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Circuit organization of the rodent medial prefrontal cortex

Cited by 169 publications

References 92 publications

Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits

Mechanisms Underlying Target Selectivity for Cell Types and Subcellular Domains in Developing Neocortical Circuits

Clinical features and power spectral entropy of electroencephalography in Wilson's disease with dystonia

Subclass‐specific expression patterns of MET receptor tyrosine kinase during development in medial prefrontal and visual cortices

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