Purpose -The purpose of this paper is to introduce new non-classical implementations of neural networks (NNs). The developed implementations are performed in the quantum, nano, and optical domains to perform the required neural computing. The various implementations of the new NNs utilizing the introduced architectures are presented, and their extensions for the utilization in the non-classical neural-systolic networks are also introduced. Design/methodology/approach -The introduced neural circuits utilize recent findings in the quantum, nano, and optical fields to implement the functionality of the basic NN. This includes the techniques of many-valued quantum computing (MVQC), carbon nanotubes (CNT), and linear optics. The extensions of implementations to non-classical neural-systolic networks using the introduced neural-systolic architectures are also presented. Findings -Novel NN implementations are introduced in this paper. NN implementation using the general scheme of MVQC is presented. The proposed method uses the many-valued quantum orthonormal computational basis states to implement such computations. Physical implementation of quantum computing (QC) is performed by controlling the potential to yield specific wavefunction as a result of solving the Schrödinger equation that governs the dynamics in the quantum domain. The CNT-based implementation of logic NNs is also introduced. New implementations of logic NNs are also introduced that utilize new linear optical circuits which use coherent light beams to perform the functionality of the basic logic multiplexer by utilizing the properties of frequency, polarization, and incident angle. The implementations of non-classical neural-systolic networks using the introduced quantum, nano, and optical neural architectures are also presented. Originality/value -The introduced NN implementations form new important directions in the NN realizations using the newly emerging technologies. Since the new quantum and optical implementations have the advantages of very high-speed and low-power consumption, and the nano implementation exists in very compact space where CNT-based field effect transistor switches reliably using much less power than a silicon-based device, the introduced implementations for non-classical neural computation are new and interesting for the design in future technologies that require the optimal design specifications of super-high speed, minimum power consumption, and minimum size, such as in low-power control of autonomous robots, adiabatic low-power very-large-scale integration circuit design for signal processing applications, QC, and nanotechnology.