Circular dichroism studies on chemically modified derivatives of concanavalin A

McCubbin, William D.; Oikawa, Kimio; Kay, Cyril M.

doi:10.1016/0014-5793(72)80294-1

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1972

1984

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Cited by 11 publications

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“…The transformed spectrum closely resembles one containing between 60 and 80% j3 structure and no a helix (Greenfield and Fasman, 1969). A similar spectrum has been observed for solutions of Con A in 0.5 m bicarbonate (pH 8.1) which were 10% in dioxane (McCubbin et al, 1972).…”

Section: Discussionsupporting

confidence: 76%

Isolation and proteolytic cleavage of the intact subunit of concanavalin A

Cunningham¹,

Wang²,

Pflumm³

et al. 1972

Biochemistry

161

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Section: Discussionsupporting

confidence: 76%

Isolation and proteolytic cleavage of the intact subunit of concanavalin A

Cunningham¹,

Wang²,

Pflumm³

et al. 1972

Biochemistry

161

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“…Recent studies by Hardman and Ainsworth (1972) suggest that lysyl groups with an anomalously low pK are present at the interior of the molecule. McCubbin et al (1972) have suggested the presence in Con A of abnormally reactive tyrosines. A discussion of the possible effect of titrating any of these side chains on the lectin's activity must await resolution of the current uncertainty about the identification of the Con A binding site (Hardman and Ainsworth, 1973;Brewer et al, 1973).…”

Section: Discussionmentioning

confidence: 99%