The circular economy is a growing and strategic topic and has motivated changes and innovations in several segments of research, businesses, financial sectors and public administration. In this context, the Emilia-Romagna Region (Italy) is considered a pioneer in Italy, due to the efforts taken for the transition towards a circular economy. It was the first Italian region to launch a specific law on the subject besides to have relevant projects. Thus, the objective of this paper is to analyse the efforts aimed at the transition to a circular economy in the Emilia-Romagna Region, Italy, considering technological, legal–regulatory, and financial points of view under a market orientation. Complementary, we pointed out the main initiatives related to the circular economy and the areas of interest. To gather data, we conducted applied, descriptive and qualitative research. The data collection was based on documental analysis, and also considering the results of previous questionnaires and interviews. In addition, we applied a dedicated questionnaire and we consider the outcomes of the project Reinwaste—Remanufacture the food supply chain by testing Innovative solutions for zero inorganic waste. The unit of analysis was the project conducted by ART-ER, entitled “Accelerare la transizione verso l’economia circolare in Emilia-Romagna: Uno studio sullo stato dell’arte, le competenze e i bisogni tecnologici e finanziari”. This paper can be useful for researchers and practitioners acting in this field, which can use the results based on public and private policies, investment decisions and further studies.