The worldwide sugar industry presents a productive inertia and a fragile sustainability due to there are marginal advances in the productivity, productive diversification, and reduction of the environmental impact in cane crop fields, sugar factories, distilleries, and non-centrifuged sugar production. The complexity of sustainability evaluation in sugar industry is highlighted by the incorporation of many criteria including both quantitative and qualitative issues, measured by different units or at least the development of standards for benchmarking. The key to successful sustainability will ultimately depend on the progress in sugarcane productivity without increasing the cultivated area and decreases the environmental impacts without the lack of coordination between public policies, stakeholders, and markets which would have benefits and wellness on social, economic, and environmental aspects. The aim of this research was to carry out a review about the sustainability frameworks, indicators, constraints, and barrier to transit the sugar industry to sustainability. The results present opportunities and strengths of sugar industry related to 2030 agenda for sustainable development and circular economy as an useful guidance to formulate strategies to maximizing the potential of the sugar industry to a sustainable biofactory.