Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138–5p/SLC7A5 axis

Zheng, Tongmei; Chen, Weifang; Wang, Xiuchun; Weiguo, Cai; Wu, F; Lin, Chaobin

doi:10.1016/j.exer.2021.108650

Cited by 18 publications

(14 citation statements)

References 25 publications

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“…Nonetheless, the rest of the circRNAs, which have only been studied in one study, have been shown to experience increased expression. Among these, miR-138-5p is considered one of the potential miRs in RB, which is located in specific ceRNA axes due to binding sites for circ_0075804 and circ-FAM158A ( 36 , 39 ). The circ_0075804/miR-138-5p/PEG10 axis was identified as a ceRNA axis in RB.…”

Section: Discussionmentioning

confidence: 99%

CircRNA-Associated CeRNAs Regulatory Axes in Retinoblastoma: A Systematic Scoping Review

et al. 2022

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Retinoblastoma (RB) is one of the most common childhood cancers caused by RB gene mutations (tumor suppressor gene in various patients). A better understanding of molecular pathways and the development of new diagnostic approaches may lead to better treatment for RB patients. The number of studies on ceRNA axes is increasing, emphasizing the significance of these axes in RB. Circular RNAs (circRNAs) play a vital role in competing endogenous RNA (ceRNA) regulatory axes by sponging microRNAs and regulating gene expression. Because of the broadness of ceRNA interaction networks, they may assist in investigating treatment targets in RB. This study conducted a systematic scoping review to evaluate verified loops of ceRNA in RB, focusing on the ceRNA axis and its relationship to circRNAs. This scoping review was carried out using a six-step strategy and the Prisma guideline, and it involved systematically searching the publications of seven databases. Out of 363 records, sixteen articles were entirely consistent with the defined inclusion criteria and were summarized in the relevant table. The majority of the studies focused on the circRNAs circ_0000527, circ_0000034, and circTET1, with approximately two-fifths of the studies focusing on a single circRNA. Understanding the many features of this regulatory structure may help elucidate RB’s unknown causative factors and provide novel molecular potential therapeutic targets and medical fields.

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Section: Discussionmentioning

confidence: 99%

CircRNA-Associated CeRNAs Regulatory Axes in Retinoblastoma: A Systematic Scoping Review

et al. 2022

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“…CircRNAs have multiple molecular mechanisms, such as nuclear transcriptional regulators of host genes, RNA-binding protein sequestering agents or miRNA sponges ( Li et al, 2018 ). Thus dysregulated circRNAs have been reported to be involved in a lot of disease such as osteoarthritis, cancer and many ocular disorders ( Zhou et al, 2019 ; Cui et al, 2020 ; Zhou et al, 2020 ; Zou et al, 2020 ; Zheng et al, 2021 ). In our study, we performed high-throughput RNA sequencing of the lacrimal sac samples from chronic dacryocystitis patients and control individuals for the first time and constructed circRNA-mRNA and circRNA-miRNA interaction networks trying to throw light on the pathogenesis of chronic dacryocystitis on RNA level.…”

Section: Discussionmentioning

confidence: 99%

Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis

Liu

Zhang

et al. 2022

Front. Genet.

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This study was designed to identify differently expressed circular RNAs (circRNAs) and investigate their potential roles in lacrimal sacs from patients with chronic dacryocystitis. The lacrimal sac samples of three chronic dacryocystitis patients and three control subjects were collected for RNA sequencing after ribosomal RNA was depleted. Differently expressed circRNAs and messenger RNAs (mRNAs) were used for co-expression analysis. CircRNA-microRNA (miRNA)-mRNA interaction network were also established by miRanda software. Meanwhile, pathway and functional enrichment analysis were conducted for the down- and up-regulated mRNAs in the circRNA-mRNA co-expression network. The expression levels of circRNAs and mRNAs in chronic dacryocystitis and control samples were validated by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). In all the 3,909 circRNAs predicted through RNA sequencing, 25 circRNAs (20 up-regulated and 5 down-regulated) expressed differently in chronic dacryocystitis samples. Besides, there identified 1,486 differentially expressed mRNAs. Of these differently expressed circRNAs and mRNAs, eight were validated by qRT-PCR, including MYH2, DSP, CD27, CCL5, FN1, has_circ_0004792, has_circ_0001062, and has_circ_0115476. Gene Ontology (GO) analysis indicated that the majority of altered mRNAs in this co-expression network were involved in immune system processes and meanwhile Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that these altered expressed mRNAs were also amplified in bacterial invasion of epithelial cells, both of which were thought to be involved in the pathogenesis of chronic dacryocystitis. In the circRNA-miRNA-mRNA interaction network, six circRNAs were found to be related to Th1 and Th2 cell differentiation, which was closely associated with the development of chronic dacryocystitis. This study identified statistically significant differences between circRNAs and mRNAs of lacrimal sac samples of chronic dacryocystitis patients and control individuals and provides novel insight into the regulatory mechanism of circRNAs, miRNAs, and mRNAs in the pathogenesis of chronic dacryocystitis.

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“…Mechanically, circ‐FAM158A sponged miR‐138‐5p to regulate the expression of SLC7A5. 225 The level of circ_0099198 and LRP6 was abnormally high, whereas the level of miR‐1287 was low in the retinoblastoma cells. Silencing circ_0099198 can inhibit proliferation and metastasis by modulating the miR‐1287/LRP6 axis.…”

Section: Lncrnas and Circrnas In Cancersmentioning

confidence: 96%

“…It promoted proliferation and migration and suppressed apoptosis. Mechanically, circ‐FAM158A sponged miR‐138‐5p to regulate the expression of SLC7A5 225 . The level of circ_0099198 and LRP6 was abnormally high, whereas the level of miR‐1287 was low in the retinoblastoma cells.…”

Section: Lncrnas and Circrnas In Cancersmentioning

confidence: 99%

LncRNAs and CircRNAs in cancer

Yin

Lin

et al. 2022

MedComm

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It is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more and more studies reveal the important roles and underlying mechanisms of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in cancer, their huge application potential in cancer therapy cannot be ignored. For example, lncRNAs can be involved in tumor‐related signal transduction pathways, cell cycle control, DNA damage, epigenetic regulation, and microRNA control. A group of studies confirmed that abnormal expression of lncRNAs can affect cancer progression. Furthermore, as covalently closed continuous circular ncRNAs, many recent studies have shown that circRNAs have regulatory effects and other important biological significances in cancer. Interestingly, circRNAs were found to have translational functions. This has greatly attracted people's attention to circRNAs research. In this review, we introduce the important roles of lncRNAs and circRNAs in some representative cancers, respectively. Furthermore, we focus on the biological functions and important clinical therapeutic implications of lnRNAs and circRNAs in neuroblastoma. Our review also focuses on providing rationale and relevant references for novel biomarkers for neuroblastoma diagnosis, prognosis, and treatment.

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Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138–5p/SLC7A5 axis

Cited by 18 publications

References 25 publications

CircRNA-Associated CeRNAs Regulatory Axes in Retinoblastoma: A Systematic Scoping Review

CircRNA-Associated CeRNAs Regulatory Axes in Retinoblastoma: A Systematic Scoping Review

Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis

LncRNAs and CircRNAs in cancer

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