2018
DOI: 10.1016/j.bbrc.2018.06.149
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Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis

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Cited by 101 publications
(66 citation statements)
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“…CircHIPK3 could abrogate the functions of target miRNAs by binding them. CircHIPK3 is involved in various biological and physiological processes, such as diabetic retinopathy [15], age-related cataracts [16], diabetes [17] and diverse types of cancers [14,[18][19][20]. CircHIPK3 plays oncogenic roles through binding to miR-124 in hepatocellular carcinoma [21] and gallbladder cancer [22].…”
Section: Introductionmentioning
confidence: 99%
“…CircHIPK3 could abrogate the functions of target miRNAs by binding them. CircHIPK3 is involved in various biological and physiological processes, such as diabetic retinopathy [15], age-related cataracts [16], diabetes [17] and diverse types of cancers [14,[18][19][20]. CircHIPK3 plays oncogenic roles through binding to miR-124 in hepatocellular carcinoma [21] and gallbladder cancer [22].…”
Section: Introductionmentioning
confidence: 99%
“…A more precise molecule mechanism is being studied to find promising alternative pharmacological means for ARC treatment. Liu et al (2018) found a general decrease in the expression of circHIPK3 in all three subtypes of ARC (cortical, nuclear, and posterior subcapsular ARC). CircHIPK3 is an abundant and highly conserved circRNA that is involved in a series of physiological or pathological activities (Xie et al, 2020).…”
Section: Age-related Cataractmentioning
confidence: 82%
“…Interaction of miR-30a with circHIPK3 can regulate the expression of VEGFC, FZD4 and WNT2, thus changing the viability and apoptosis of retinal pigmented epithelial cells [39] . More importantly, our previous study showed that upregulation of miR-193a caused by downregulation of circHIPK3 can regulate cataract formation by targeting CRAYY [40] . However, there are few studies reporting the function and characterization of exosomes and miRNAs in diabetes and cataracts.…”
Section: Discussionmentioning
confidence: 98%