Circular RNA hsa_circ_0054537 sponges miR-130a-3p to promote the progression of renal cell carcinoma through regulating cMet pathway

Li, Rui; Luo, Sheng; Zhang, Dahu

doi:10.1016/j.gene.2020.144811

Cited by 32 publications

(26 citation statements)

References 30 publications

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“…Comparisons between groups were performed using one-way ANOVA. P < 0.05 vs. control or NC group well as therapeutic targets for ccRCC [19], and a recent research has discovered the tumor-suppressing role of miR-130a-3p in renal carcinoma cells [16]. Similarly, in our study, miR-130a-3p also functioned as a tumor suppressor in ccRCC by suppressing cell proliferation and promoting apoptosis.…”

Section: Discussionsupporting

confidence: 80%

“…In a recent study, Li et al found that miR-130a-3p was down-regulated in renal carcinoma cells. Up-regulation of miR-130a-3p could inhibit the renal carcinoma cell proliferation and migration, and promote apoptosis, suggesting the tumor-suppressing effect of miR-130a-3p in renal carcinoma [16]. However, the role of miR-130a-3p in ccRCC remains unclear, especially its signaling pathway, crosstalk with some lncRNAs in the tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

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Potential diagnostic and prognostic value and regulatory relationship of long noncoding RNA CCAT1 and miR-130a-3p in clear cell renal cell carcinoma

Jing

Wang

et al. 2021

Cancer Cell Int

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Background MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) could interact with each other to play a vital role in the pathogenesis of cancers. We aimed to examine the expression profile, clinical significance and regulatory relationship of miR-130a-3p and its predicted interactive lncRNA in clear cell renal cell carcinoma (ccRCC). Methods Bioinformatics analysis was used to predict lncRNAs binding with miR-130a-3p. qRT-PCR was employed to detect the expression levels of miR-130a-3p and the miRNA-targeted lncRNA, and their clinical values in ccRCC were clarified. The lncRNA sponge potential of miR-130a-3p was assessed through dual-luciferase reporter assay and the biological effects of them were observed. Results Colon cancer associated transcript 1 (CCAT1) directly interacted with miR-130a-3p and negatively regulated miR-130a-3p expression. CCAT1 was upregulated and miR-130a-3p was downregulated in ccRCC cell line and tissues (all P < 0.05). High CCAT1 and low miR-130a-3p expression was correlated with larger tumor size and advanced TNM stage in ccRCC patients. High CCAT1 level suggested a poor survival prognosis. There was a negative association between CCAT1 and miR-130a-3p expression (r = − 0.373, P = 0.010). MiR-130a-3p mimic and si-CCAT1 inhibited ccRCC cell proliferation and invasion, and induced apoptosis. Conclusions CCAT1/miR-130a-3p axis may have potential to serve as a novel diagnostic and prognostic target of ccRCC patients.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Potential diagnostic and prognostic value and regulatory relationship of long noncoding RNA CCAT1 and miR-130a-3p in clear cell renal cell carcinoma

Jing

Wang

et al. 2021

Cancer Cell Int

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“…Various circR-NAs exist in mammalian cells and regulate a broad range of biological processes through various mechanisms, including sponging of microRNAs (miRNAs) [10]. Cir-cRNA circ_0054537 could sponge miR-130a-3p to promote the progression of renal cell carcinoma through regulating cMet pathway, and circ_0008532 promotes bladder cancer progression by regulation of the miR-155-5p/miR-330-5p/MTGR1 axis [11,12]. However, the role of circ_0004913 in cancer is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Circ_0004913 sponges miR-1290 and regulates FOXC1 to inhibit the proliferation of hepatocellular carcinoma

Han

et al. 2020

Cancer Cell Int

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Background: Circular RNA (circRNA), an novel type of non-coding RNA, could interact with miRNA and protein molecules to regulate the occurrence and progression of hepatocellular carcinoma (HCC). However, little is known about the pathogenesis of circ_0004913 in HCC. Materials: Through the GEO (Gene Expression Omnibus database) to find dysfunctional circRNAs in HCC, and circ_0004913 was selected as the research object. Quantitative reverse transcription PCR (qRT-PCR) was used to detect the expression level of circ_0067934 in HCC tissues and cells. CCK-8, Edu and flow cytometry assays were used to determine the malignant behavior of transfected HCC cells. Mechanistically, RNA immunoprecipitation and dualluciferase reporter gene assay were performed to explore the relation between circ_0067934, miR-1290 and FOXC1 (Forkhead box C1) in HCC. Results: The expression of circ_0004913 was down-regulated in HCC tissues and cell lines, while the overexpression of circ_0004913 attenuates the malignant behavior of HCC cells. Bioinformatics predicted that circ_0004913 interacts with miR-1290, which targeted FOXC1 mRNA. In fact, miR-1290 promoted the malignant behavior of HCC cells, while FOXC1 had the opposite effect. In addition, circ_0004913 overexpression enhanced FOXC1 expression by reducing miR-1290 expression, thereby inhibiting the proliferation of HCC cells. Conclusions: Circ_0004913 / miR-1290 / FOXC1 regulatory axis could inhibit the progress of HCC. Our findings may provide potential new targets for the diagnosis and treatment of HCC.

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“…CircRNA circ_0054537 could sponge miR-130a-3p to promote the progression of renal cell carcinoma through regulating cMet pathway, and circ_0008532 promotes bladder cancer progression by regulation of the miR-155-5p/miR-330-5p/MTGR1 axis [11,12]. However, the role of circ_0004913 in cancer is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Circ_0004913 sponges miR-1290 and regulates FOXC1 to inhibit the proliferation of hepatocellular carcinoma

Han

et al. 2020

Preprint

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Circular RNA hsa_circ_0054537 sponges miR-130a-3p to promote the progression of renal cell carcinoma through regulating cMet pathway

Cited by 32 publications

References 30 publications

Potential diagnostic and prognostic value and regulatory relationship of long noncoding RNA CCAT1 and miR-130a-3p in clear cell renal cell carcinoma

Potential diagnostic and prognostic value and regulatory relationship of long noncoding RNA CCAT1 and miR-130a-3p in clear cell renal cell carcinoma

Circ_0004913 sponges miR-1290 and regulates FOXC1 to inhibit the proliferation of hepatocellular carcinoma

Circ_0004913 sponges miR-1290 and regulates FOXC1 to inhibit the proliferation of hepatocellular carcinoma

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